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Year Number of Results
2014 1
2016 2
2017 4
2018 1
2019 1
2020 1
2021 0
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Page 1
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.
Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. Veit G, et al. Among authors: avramescu rg. Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935. Mol Biol Cell. 2016. PMID: 26823392 Free PMC article.
Mutation-specific dual potentiators maximize rescue of CFTR gating mutants.
Veit G, Da Fonte DF, Avramescu RG, Premchandar A, Bagdany M, Xu H, Bensinger D, Stubba D, Schmidt B, Matouk E, Lukacs GL. Veit G, et al. Among authors: avramescu rg. J Cyst Fibros. 2020 Mar;19(2):236-244. doi: 10.1016/j.jcf.2019.10.011. Epub 2019 Oct 31. J Cyst Fibros. 2020. PMID: 31678009 Free PMC article.
Structure-guided combination therapy to potently improve the function of mutant CFTRs.
Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL. Veit G, et al. Among authors: avramescu rg. Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8. Nat Med. 2018. PMID: 30297908 Free PMC article.
Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.
Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL. Bagdany M, et al. Among authors: avramescu rg. Nat Commun. 2017 Aug 30;8(1):398. doi: 10.1038/s41467-017-00444-4. Nat Commun. 2017. PMID: 28855508 Free PMC article.
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Among authors: avramescu rg. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.