Ayrton AD[au] - Search Results

Year	Number of Results
1987	2
1988	4
1989	4
1990	4
1991	1
1992	3
1993	1
1994	3
1995	1
2001	1
2005	1
2006	1
2008	1
2009	1
2012	1
2024	0

1

8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.

Heightman TD, Gaster LM, Pardoe SL, Pilleux JP, Hadley MS, Middlemiss DN, Price GW, Roberts C, Scott CM, Watson JM, Gordon LJ, Holland VA, Powles J, Riley GJ, Stean TO, Trail BK, Upton N, Austin NE, Ayrton AD, Coleman T, Cutler L. Heightman TD, et al. Among authors: ayrton ad. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4370-4. doi: 10.1016/j.bmcl.2005.06.042. Bioorg Med Chem Lett. 2005. PMID: 16039851

2

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.

Bloomer JC, Baldwin SJ, Smith GJ, Ayrton AD, Clarke SE, Chenery RJ. Bloomer JC, et al. Among authors: ayrton ad. Br J Clin Pharmacol. 1994 Dec;38(6):557-66. doi: 10.1111/j.1365-2125.1994.tb04397.x. Br J Clin Pharmacol. 1994. PMID: 7888294 Free PMC article.

3

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay.

Thiel-Demby VE, Humphreys JE, St John Williams LA, Ellens HM, Shah N, Ayrton AD, Polli JW. Thiel-Demby VE, et al. Among authors: ayrton ad. Mol Pharm. 2009 Jan-Feb;6(1):11-8. doi: 10.1021/mp800122b. Mol Pharm. 2009. PMID: 19248229

4

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE. Sakatis MZ, et al. Among authors: ayrton ad. Chem Res Toxicol. 2012 Oct 15;25(10):2067-82. doi: 10.1021/tx300075j. Epub 2012 Sep 19. Chem Res Toxicol. 2012. PMID: 22931300

5

The induction of P450 I proteins by aromatic amines may be related to their carcinogenic potential.

Ayrton AD, McFarlane M, Walker R, Neville S, Ioannides C. Ayrton AD, et al. Carcinogenesis. 1990 May;11(5):803-9. doi: 10.1093/carcin/11.5.803. Carcinogenesis. 1990. PMID: 2335009

6

Extrapolation of in vitro antimutagenicity to the in vivo situation: the case for anthraflavic acid.

Ioannides C, Ayrton AD, Lewis DF, Walker R. Ioannides C, et al. Among authors: ayrton ad. Basic Life Sci. 1993;61:103-10. doi: 10.1007/978-1-4615-2984-2_9. Basic Life Sci. 1993. PMID: 8304922 Review. No abstract available.

7

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.

Deeni YY, Paine MJ, Ayrton AD, Clarke SE, Chenery R, Wolf CR. Deeni YY, et al. Among authors: ayrton ad. Arch Biochem Biophys. 2001 Dec 1;396(1):16-24. doi: 10.1006/abbi.2001.2585. Arch Biochem Biophys. 2001. PMID: 11716457

8

Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity.

Ayrton AD, Ioannides C, Parke DV. Ayrton AD, et al. Biochem Pharmacol. 1991 Jun 21;42(1):109-15. doi: 10.1016/0006-2952(91)90688-2. Biochem Pharmacol. 1991. PMID: 2069584

9

Characterization of the inhibition of P4501A2 by furafylline.

Clarke SE, Ayrton AD, Chenery RJ. Clarke SE, et al. Among authors: ayrton ad. Xenobiotica. 1994 Jun;24(6):517-26. doi: 10.3109/00498259409043254. Xenobiotica. 1994. PMID: 7975717

10

Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes.

Clarke SE, Baldwin SJ, Bloomer JC, Ayrton AD, Sozio RS, Chenery RJ. Clarke SE, et al. Among authors: ayrton ad. Chem Res Toxicol. 1994 Nov-Dec;7(6):836-42. doi: 10.1021/tx00042a018. Chem Res Toxicol. 1994. PMID: 7696540

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