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TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy.
Endo R, Kinefuchi H, Sawada M, Kikuchi R, Kojima W, Matsuda N, Yamano K. Endo R, et al. J Biol Chem. 2024 Oct;300(10):107775. doi: 10.1016/j.jbc.2024.107775. Epub 2024 Sep 12. J Biol Chem. 2024. PMID: 39276928 Free PMC article.
Further, a series of AZI2 and TBKBP1 knockout constructs combined with an OPTN knockout showed that AZI2, but not TBKBP1, impacts NDP52-driven mitophagy. ...These results suggest that AZI2, in concert with TBK1, plays an important role in NDP52-driven mitopha …
Further, a series of AZI2 and TBKBP1 knockout constructs combined with an OPTN knockout showed that AZI2, but not TBKBP1, impa …
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases.
Ujevic A, Knizkova D, Synackova A, Pribikova M, Trivic T, Dalinskaya A, Drobek A, Niederlova V, Paprckova D, De Guia R, Kasparek P, Prochazka J, Labaj J, Fedosieieva O, Roeck BF, Mihola O, Trachtulec Z, Sedlacek R, Stepanek O, Draber P. Ujevic A, et al. Nat Commun. 2024 Nov 19;15(1):10013. doi: 10.1038/s41467-024-54399-4. Nat Commun. 2024. PMID: 39562788 Free PMC article.
Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by regulating the activation of TBK1 kinase. Mice lacking either TANK or AZI2 do not show an overt phenotype. ...While TANK binds directly to the adapter NEMO, AZI2 is …
Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by regulating the activation of TBK1 kina …
AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia.
Wei M, Zheng Y, Xu J, Sun Q. Wei M, et al. Pathog Dis. 2022 Jul 1;80(1):ftac016. doi: 10.1093/femspd/ftac016. Pathog Dis. 2022. PMID: 35595469
The lung infection mouse model was established by using PR8 H1N1 virus in AZI2 germline knockout (AZI2-/-) and wild-type (WT) mice. In addition, HEK293T cell-based luciferase reporter assays were used to investigate the regulatory effects of AZI2 on type I in …
The lung infection mouse model was established by using PR8 H1N1 virus in AZI2 germline knockout (AZI2-/-) and wild-type (WT) …
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
Yeo SK, Haas M, Manupati K, Hao M, Yang F, Chen S, Guan JL. Yeo SK, et al. Autophagy. 2024 Mar;20(3):525-540. doi: 10.1080/15548627.2023.2259775. Epub 2023 Sep 29. Autophagy. 2024. PMID: 37733921 Free PMC article.
Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective m …
Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy fo …
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Lafont E, Draber P, Rieser E, Reichert M, Kupka S, de Miguel D, Draberova H, von Mässenhausen A, Bhamra A, Henderson S, Wojdyla K, Chalk A, Surinova S, Linkermann A, Walczak H. Lafont E, et al. Nat Cell Biol. 2018 Dec;20(12):1389-1399. doi: 10.1038/s41556-018-0229-6. Epub 2018 Nov 12. Nat Cell Biol. 2018. PMID: 30420664 Free PMC article.
Strikingly, NEMO (also known as IKKgamma), which mostly, but not exclusively, binds the TNFR1-SC via M1 ubiquitin, mediates the recruitment of the adaptors TANK and NAP1 (also known as AZI2). TANK is constitutively associated with both TBK1 and IKKepsilon, while NAP1 is as …
Strikingly, NEMO (also known as IKKgamma), which mostly, but not exclusively, binds the TNFR1-SC via M1 ubiquitin, mediates the recruitment …
(AZI2)3'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders.
Liu K, Yu J, Zhao J, Zhou Y, Xiong N, Xu J, Wang T, Bell RL, Qing H, Lin Z. Liu K, et al. Mol Neurobiol. 2018 Jul;55(7):5611-5622. doi: 10.1007/s12035-017-0781-2. Epub 2017 Oct 5. Mol Neurobiol. 2018. PMID: 28983843 Free PMC article.
Here, we used a common genetic variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, (AZI2)3'UTR, for SLC6A3. (AZI2)3'UTR is a 3' untranslated region (3'UTR) of the human 5-Azacytidine Induced 2 gene (AZI2) …
Here, we used a common genetic variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, ( …
5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S. Maruyama K, et al. J Biol Chem. 2015 Apr 10;290(15):9377-86. doi: 10.1074/jbc.M114.631374. Epub 2015 Feb 17. J Biol Chem. 2015. PMID: 25691576 Free PMC article.
A previous in vitro study showed that AZI2 is involved in dendritic cell differentiation. However, the roles of AZI2 in immunity and its pleiotropic functions are unknown in vivo. Here we report that AZI2 knock-out mice exhibit normal dendritic cell different …
A previous in vitro study showed that AZI2 is involved in dendritic cell differentiation. However, the roles of AZI2 in immuni …
Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O. Fukasaka M, et al. J Immunol. 2013 Jun 1;190(11):5702-11. doi: 10.4049/jimmunol.1203155. Epub 2013 Apr 22. J Immunol. 2013. PMID: 23610142
In contrast, AZI2, but not TBKBP1, is critical for the differentiation of conventional dendritic cells (cDCs) from bone marrow cells in response to GM-CSF. AZI2 controls GM-CSF-induced cell cycling of bone marrow cells via TBK1. GM-CSF-derived DCs from AZI2-d …
In contrast, AZI2, but not TBKBP1, is critical for the differentiation of conventional dendritic cells (cDCs) from bone marrow cells …
Functional validation of a finding from a mouse genome-wide association study shows that Azi2 influences the acute locomotor stimulant response to methamphetamine.
Zhou X, Barkley-Levenson AM, Montilla-Perez P, Telese F, Palmer AA. Zhou X, et al. Genes Brain Behav. 2021 Sep;20(7):e12760. doi: 10.1111/gbb.12760. Epub 2021 Jul 10. Genes Brain Behav. 2021. PMID: 34173327 Free article.
We evaluated the relationship between Azi2, Azi2 3'UTR and Slc6a3 expression in the ventral tegmental area of wildtype, mutant Azi2 heterozygotes and mutant Azi2 homozygotes and in a new cohort of outbred CFW mice where both allele mapped in our prior …
We evaluated the relationship between Azi2, Azi2 3'UTR and Slc6a3 expression in the ventral tegmental area of wildtype, mutant …
FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.
Okamoto T, Yeo SK, Hao M, Copley MR, Haas MA, Chen S, Guan JL. Okamoto T, et al. Cancer Res. 2020 Sep 1;80(17):3580-3592. doi: 10.1158/0008-5472.CAN-20-0519. Epub 2020 Jun 24. Cancer Res. 2020. PMID: 32580962 Free PMC article.
FIP200 also interacted with the TBK1 adaptor protein, AZI2, which was crucial for activation of TBK1 following FIP200 ablation. Accordingly, disrupting the noncanonical autophagy function of FIP200 in combination with ICI therapy led to superior, durable responses in immun …
FIP200 also interacted with the TBK1 adaptor protein, AZI2, which was crucial for activation of TBK1 following FIP200 ablation. Accor …
29 results