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101 results

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Page 1
Upping the antizyme: AZIN1 directs stem cell fate.
Ladel L, Jamieson CHM. Ladel L, et al. Blood. 2021 Nov 18;138(20):1910-1911. doi: 10.1182/blood.2021013700. Blood. 2021. PMID: 34792575 Free PMC article. No abstract available.
AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer.
Ghalali A, Wang L, Stopsack KH, Rice JM, Wu S, Wu CL, Zetter BR, Rogers MS. Ghalali A, et al. Exp Mol Med. 2022 Oct;54(10):1713-1726. doi: 10.1038/s12276-022-00845-6. Epub 2022 Oct 6. Exp Mol Med. 2022. PMID: 36202978 Free PMC article.
The transcript encoding Antizyme Inhibitor 1 (AZIN1) is frequently edited in various cancers, and this editing is associated with enhanced tumor aggressiveness. After comparison of wild-type AZIN1 (wtAZIN1) and edited AZIN1 (edAZIN1, which contains a Ser367Gl …
The transcript encoding Antizyme Inhibitor 1 (AZIN1) is frequently edited in various cancers, and this editing is associated with enh …
AZIN1 level is increased in medulloblastoma and correlates with c-Myc activity and tumor phenotype.
Sesen J, Martinez T, Busatto S, Poluben L, Nassour H, Stone C, Ashok K, Moses MA, Smith ER, Ghalali A. Sesen J, et al. J Exp Clin Cancer Res. 2025 Feb 17;44(1):56. doi: 10.1186/s13046-025-03274-1. J Exp Clin Cancer Res. 2025. PMID: 39962590 Free PMC article.
BACKGROUND: AZIN1 is a cell cycle regulator that is upregulated in a variety of cancers. AZIN1 overexpression can induce a more aggressive tumor phenotype via increased binding and resultant inhibition of antizyme. ...RESULTS: Here, we investigated the role of AZ …
BACKGROUND: AZIN1 is a cell cycle regulator that is upregulated in a variety of cancers. AZIN1 overexpression can induce a mor …
LncRNA AZIN1-AS1 ameliorates myocardial ischemia-reperfusion injury by targeting miR-6838-5p/WNT3A axis to activate Wnt-beta/catenin signaling pathway.
Zhang G, Ding L, Sun G, Liu Z, Ou W, Wang B, Sun Y. Zhang G, et al. In Vitro Cell Dev Biol Anim. 2022 Jan;58(1):54-68. doi: 10.1007/s11626-022-00646-1. Epub 2022 Jan 21. In Vitro Cell Dev Biol Anim. 2022. PMID: 35064471
However, overexpression of AZIN1-AS1 recovered abovementioned effects. Additionally, miR-6838-5p was found to be the direct target of AZIN1-AS1 and exhibited negative correlation with AZIN1-AS1. Moreover, miR-6838-5p inhibitor effectively eliminated the effec …
However, overexpression of AZIN1-AS1 recovered abovementioned effects. Additionally, miR-6838-5p was found to be the direct target of …
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
Xing Y, Nakahama T, Wu Y, Inoue M, Kim JI, Todo H, Shibuya T, Kato Y, Kawahara Y. Xing Y, et al. J Biol Chem. 2023 Jul;299(7):104840. doi: 10.1016/j.jbc.2023.104840. Epub 2023 May 18. J Biol Chem. 2023. PMID: 37209819 Free PMC article.
We previously found that RNA editing at two coding sites of antizyme inhibitor 1 (AZIN1) is sustained in Adar1 p110/Aadr2 double KO mice. However, the molecular mechanisms underlying RNA editing of AZIN1 remain unknown. ...Therefore, deletion of a nuclear export sig …
We previously found that RNA editing at two coding sites of antizyme inhibitor 1 (AZIN1) is sustained in Adar1 p110/Aadr2 double KO m …
AZIN1-AS1, A Novel Oncogenic LncRNA, Promotes the Progression of Non-Small Cell Lung Cancer by Regulating MiR-513b-5p and DUSP11.
Cai Y, Wu Q, Liu Y, Wang J. Cai Y, et al. Onco Targets Ther. 2020 Oct 9;13:9667-9678. doi: 10.2147/OTT.S261497. eCollection 2020. Onco Targets Ther. 2020. PMID: 33116570 Free PMC article.
The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. METHODS: Expressions of AZIN1-AS1 and miR-513b-5p in NSCLC samples were detected by qRT-PCR. ...What's more, AZIN1-AS1 could d …
The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. …
Toxoplasma gondii macrophage migration inhibitory factor shows anti-Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction.
Yoon C, Kim HK, Ham YS, Gil WJ, Mun SJ, Cho E, Yuk JM, Yang CS. Yoon C, et al. Sci Adv. 2024 Oct 25;10(43):eadq0101. doi: 10.1126/sciadv.adq0101. Epub 2024 Oct 25. Sci Adv. 2024. PMID: 39453997 Free PMC article.
We observed that TgMIF that interacts with CD74, antizyme inhibitor 1 (AZIN1), and signal transducer and activator of transcription 1 (STAT1) modulates endocytosis, restoration of mitochondrial function, and macrophage polarization, respectively. ...These results demonstra …
We observed that TgMIF that interacts with CD74, antizyme inhibitor 1 (AZIN1), and signal transducer and activator of transcription 1 …
ADAR1 affects gastric cancer cell metastasis and reverses cisplatin resistance through AZIN1.
Wang H, Yang L, Liu R, He H, Zhang M, Xu Y. Wang H, et al. Anticancer Drugs. 2023 Nov 1;34(10):1132-1145. doi: 10.1097/CAD.0000000000001516. Epub 2023 Apr 28. Anticancer Drugs. 2023. PMID: 37104086 Free PMC article.
The effect of ADAR1 siRNA combined with AZIN1 siRNA was more significant. In-vivo, the knockdown of ADAR1 significantly inhibited tumor growth and AZIN1 expression. ADAR1 and AZIN1 are antimetastatic targets of gastric cancer, and AZIN1 is a downstream …
The effect of ADAR1 siRNA combined with AZIN1 siRNA was more significant. In-vivo, the knockdown of ADAR1 significantly inhibited tum …
AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer.
Shigeyasu K, Okugawa Y, Toden S, Miyoshi J, Toiyama Y, Nagasaka T, Takahashi N, Kusunoki M, Takayama T, Yamada Y, Fujiwara T, Chen L, Goel A. Shigeyasu K, et al. JCI Insight. 2018 Jun 21;3(12):e99976. doi: 10.1172/jci.insight.99976. eCollection 2018 Jun 21. JCI Insight. 2018. PMID: 29925690 Free PMC article.
Furthermore, elevated AZIN1 editing identified high-risk stage II CRC patients. Mechanistically, edited AZIN1 enhances stemness and appears to drive the metastatic processes. We have demonstrated that edited AZIN1 functions as an oncogene and a potential ther …
Furthermore, elevated AZIN1 editing identified high-risk stage II CRC patients. Mechanistically, edited AZIN1 enhances stemnes …
ADAR1 and AZIN1 RNA editing function as an oncogene and contributes to immortalization in endometrial cancer.
Nakamura K, Shigeyasu K, Okamoto K, Matsuoka H, Masuyama H. Nakamura K, et al. Gynecol Oncol. 2022 Aug;166(2):326-333. doi: 10.1016/j.ygyno.2022.05.026. Epub 2022 Jun 11. Gynecol Oncol. 2022. PMID: 35697535

ADAR1 expression was significantly correlated with AZIN1 RNA editing level (R = 0.729, R(2) = 0.547, P < 0.001). Multivariate analysis indicated that higher ADAR1 expression along with AZIN1 RNA editing is an independent predictor of prognosis in EC patients (P =

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ADAR1 expression was significantly correlated with AZIN1 RNA editing level (R = 0.729, R(2) = 0.547, P < 0.001). Multivariate anal

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101 results