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Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly.

Viney L, Bürckstümmer T, Eddington C, Mietzsch M, Choudhry M, Henley T, Agbandje-McKenna M. Viney L, et al. Among authors: burckstummer t. J Virol. 2021 Jan 13;95(7):e02023-20. doi: 10.1128/JVI.02023-20. Online ahead of print. J Virol. 2021. PMID: 33441336 Free PMC article.

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Biological plasticity rescues target activity in CRISPR knock outs.

Smits AH, Ziebell F, Joberty G, Zinn N, Mueller WF, Clauder-Münster S, Eberhard D, Fälth Savitski M, Grandi P, Jakob P, Michon AM, Sun H, Tessmer K, Bürckstümmer T, Bantscheff M, Steinmetz LM, Drewes G, Huber W. Smits AH, et al. Among authors: burckstummer t. Nat Methods. 2019 Nov;16(11):1087-1093. doi: 10.1038/s41592-019-0614-5. Epub 2019 Oct 28. Nat Methods. 2019. PMID: 31659326

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A small cassette enables conditional gene inactivation by CRISPR/Cas9.

Guzzardo PM, Rashkova C, Dos Santos RL, Tehrani R, Collin P, Bürckstümmer T. Guzzardo PM, et al. Among authors: burckstummer t. Sci Rep. 2017 Dec 1;7(1):16770. doi: 10.1038/s41598-017-16931-z. Sci Rep. 2017. PMID: 29196747 Free PMC article.

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A generic strategy for CRISPR-Cas9-mediated gene tagging.

Lackner DH, Carré A, Guzzardo PM, Banning C, Mangena R, Henley T, Oberndorfer S, Gapp BV, Nijman SMB, Brummelkamp TR, Bürckstümmer T. Lackner DH, et al. Among authors: burckstummer t. Nat Commun. 2015 Dec 17;6:10237. doi: 10.1038/ncomms10237. Nat Commun. 2015. PMID: 26674669 Free PMC article.

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Parallel reverse genetic screening in mutant human cells using transcriptomics.

Gapp BV, Konopka T, Penz T, Dalal V, Bürckstümmer T, Bock C, Nijman SM. Gapp BV, et al. Among authors: burckstummer t. Mol Syst Biol. 2016 Aug 1;12(8):879. doi: 10.15252/msb.20166890. Mol Syst Biol. 2016. PMID: 27482057 Free PMC article.

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Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology.

Lekomtsev S, Aligianni S, Lapao A, Bürckstümmer T. Lekomtsev S, et al. Among authors: burckstummer t. BMC Genomics. 2016 Sep 17;17(1):739. doi: 10.1186/s12864-016-3084-5. BMC Genomics. 2016. PMID: 27640184 Free PMC article.

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Functional dissection of the TBK1 molecular network.

Goncalves A, Bürckstümmer T, Dixit E, Scheicher R, Górna MW, Karayel E, Sugar C, Stukalov A, Berg T, Kralovics R, Planyavsky M, Bennett KL, Colinge J, Superti-Furga G. Goncalves A, et al. Among authors: burckstummer t. PLoS One. 2011;6(9):e23971. doi: 10.1371/journal.pone.0023971. Epub 2011 Sep 8. PLoS One. 2011. PMID: 21931631 Free PMC article.

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Initial characterization of the human central proteome.

Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J. Burkard TR, et al. Among authors: burckstummer t. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. BMC Syst Biol. 2011. PMID: 21269460 Free PMC article.

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IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G. Pichlmair A, et al. Among authors: burckstummer t. Nat Immunol. 2011 Jun 5;12(7):624-30. doi: 10.1038/ni.2048. Nat Immunol. 2011. PMID: 21642987

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Experimental characterization of the human non-sequence-specific nucleic acid interactome.

Dürnberger G, Bürckstümmer T, Huber K, Giambruno R, Doerks T, Karayel E, Burkard TR, Kaupe I, Müller AC, Schönegger A, Ecker GF, Lohninger H, Bork P, Bennett KL, Superti-Furga G, Colinge J. Dürnberger G, et al. Among authors: burckstummer t. Genome Biol. 2013 Jul 31;14(7):R81. doi: 10.1186/gb-2013-14-7-r81. Genome Biol. 2013. PMID: 23902751 Free PMC article.

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