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27 results

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Page 1
Did you mean b kayarian (1 results)?
SATB2 organizes the 3D genome architecture of cognition in cortical neurons.
Wahl N, Espeso-Gil S, Chietera P, Nagel A, Laighneach A, Morris DW, Rajarajan P, Akbarian S, Dechant G, Apostolova G. Wahl N, et al. Mol Cell. 2024 Feb 15;84(4):621-639.e9. doi: 10.1016/j.molcel.2023.12.024. Epub 2024 Jan 19. Mol Cell. 2024. PMID: 38244545 Free PMC article.
We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing their expression. It also alters A/B compartments, topologically associating domains, and frequently interacting regions. ...
We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing thei …
Single chromatin fiber profiling and nucleosome position mapping in the human brain.
Peter CJ, Agarwal A, Watanabe R, Kassim BS, Wang X, Lambert TY, Javidfar B, Evans V, Dawson T, Fridrikh M, Girdhar K, Roussos P, Nageshwaran SK, Tsankova NM, Sebra RP, Vollger MR, Stergachis AB, Hasson D, Akbarian S. Peter CJ, et al. Cell Rep Methods. 2024 Dec 16;4(12):100911. doi: 10.1016/j.crmeth.2024.100911. Epub 2024 Dec 3. Cell Rep Methods. 2024. PMID: 39631398 Free PMC article.
Somatic instability of the FGF14-SCA27B GAA•TTC repeat reveals a marked expansion bias in the cerebellum.
Pellerin D, Méreaux JL, Boluda S, Danzi MC, Dicaire MJ, Davoine CS, Genis D, Spurdens G, Ashton C, Hammond JM, Gerhart BJ, Chelban V, Le PU, Safisamghabadi M, Yanick C, Lee H, Nageshwaran SK, Matos-Rodrigues G, Jaunmuktane Z, Petrecca K, Akbarian S, Nussenzweig A, Usdin K, Renaud M, Bonnet C, Ravenscroft G, Saporta MA, Napierala JS, Houlden H, Deveson IW, Napierala M, Brice A, Molina Porcel L, Seilhean D, Zuchner S, Durr A, Brais B. Pellerin D, et al. Brain. 2025 Apr 3;148(4):1258-1270. doi: 10.1093/brain/awae312. Brain. 2025. PMID: 39378335 Free PMC article.
The epigenomics of schizophrenia, in the mouse.
Javidfar B, Park R, Kassim BS, Bicks LK, Akbarian S. Javidfar B, et al. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):631-640. doi: 10.1002/ajmg.b.32566. Epub 2017 Jul 12. Am J Med Genet B Neuropsychiatr Genet. 2017. PMID: 28699694 Free PMC article. Review.
Modulating Insulin Fibrillation Using Engineered B-Chains with Mutated C-Termini.
Akbarian M, Yousefi R, Moosavi-Movahedi AA, Ahmad A, Uversky VN. Akbarian M, et al. Biophys J. 2019 Nov 5;117(9):1626-1641. doi: 10.1016/j.bpj.2019.09.022. Epub 2019 Sep 23. Biophys J. 2019. PMID: 31607389 Free PMC article.
Several previous studies suggested the importance of the C-terminal region of B-chain in this pathway. Therefore, we generated the T30R and K29R/T30R mutants of insulin B-chain. ...The mutant insulins and their B-chains displayed significant resistance agains …
Several previous studies suggested the importance of the C-terminal region of B-chain in this pathway. Therefore, we generated the T3 …
Functional implications of polygenic risk for schizophrenia in human neurons.
Michael Deans PJ, Retallick-Townsley KG, Li A, Seah C, Johnson J, Garcia Gonzalez J, Cao E, Schrode N, Yu A, Cartwright S, Voloudakis G, Zhang W, Wang M, Fullard JF, Girdhar K, Stahl E, Akbarian S, Zhang B, Roussos P, O'Reilly P, Huckins LM, Brennand KJ. Michael Deans PJ, et al. Nat Commun. 2026 Jan 10;17(1):1355. doi: 10.1038/s41467-025-67959-z. Nat Commun. 2026. PMID: 41519853 Free PMC article.
Control-independent mosaic single nucleotide variant detection with DeepMosaic.
Yang X, Xu X, Breuss MW, Antaki D, Ball LL, Chung C, Shen J, Li C, George RD, Wang Y, Bae T, Cheng Y, Abyzov A, Wei L, Alexandrov LB, Sebat JL; NIMH Brain Somatic Mosaicism Network; Gleeson JG. Yang X, et al. Nat Biotechnol. 2023 Jun;41(6):870-877. doi: 10.1038/s41587-022-01559-w. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593400 Free PMC article.
Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions.
Chandrasekaran S, Espeso-Gil S, Loh YE, Javidfar B, Kassim B, Zhu Y, Zhang Y, Dong Y, Bicks LK, Li H, Rajarajan P, Peter CJ, Sun D, Agullo-Pascual E, Iskhakova M, Estill M, Lesch BJ, Shen L, Jiang Y, Akbarian S. Chandrasekaran S, et al. Nat Commun. 2021 Dec 13;12(1):7243. doi: 10.1038/s41467-021-26862-z. Nat Commun. 2021. PMID: 34903713 Free PMC article.
Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic B(2)(NeuN+) megabase-scaling subcompartment. Single molecule …
Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retr …
27 results