Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.
Ravichandran G, Neumann K, Berkhout LK, Weidemann S, Langeneckert AE, Schwinge D, Poch T, Huber S, Schiller B, Hess LU, Ziegler AE, Oldhafer KJ, Barikbin R, Schramm C, Altfeld M, Tiegs G.
Ravichandran G, et al.
J Hepatol. 2019 Oct;71(4):773-782. doi: 10.1016/j.jhep.2019.05.023. Epub 2019 Jun 5.
J Hepatol. 2019.
PMID: 31173810
The contribution of lymphocytes to liver pathology was assessed in Mdr2(-/-) x Rag1(-/-) mice, which lack T and B cells, and following depletion of CD90.2(+) or natural killer (NK)p46(+) cells in Mdr2(-/-) mice. ...The complete absence of IFNgamma in Mdr2(-/-)x Ifng(-/-) m …
The contribution of lymphocytes to liver pathology was assessed in Mdr2(-/-) x Rag1(-/-) mice, which lack T and B cells, and followin …