The role of IL-39 in autoimmune diseases: From general to immunopathogenesis.
Ahmadi P, Janzadeh A, Honardoost M, Taherkhani S, Doyle D, Mojarad N.
Ahmadi P, et al.
Cytokine. 2025 Aug;192:156969. doi: 10.1016/j.cyto.2025.156969. Epub 2025 May 28.
Cytokine. 2025.
PMID: 40440970
Review.
IL-39, a cytokine from the IL-12 family that appears to be produced primarily by B cells, consists of the IL-23p19 and Ebi3 subunits, which signal through IL-23R/gp130 to activate STAT1/STAT3. Some studies suggest elevated IL-39 levels in certain autoimmune conditions, suc …
IL-39, a cytokine from the IL-12 family that appears to be produced primarily by B cells, consists of the IL-23p19 and Ebi3 subunits, …