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NKT cell self-reactivity: evolutionary master key of immune homeostasis?
Issazadeh-Navikas S. Issazadeh-Navikas S. J Mol Cell Biol. 2012 Apr;4(2):70-8. doi: 10.1093/jmcb/mjr035. Epub 2011 Dec 13. J Mol Cell Biol. 2012. PMID: 22167750 Review.
Specialized cells have arisen as the sentinels of these functions, including macrophages, natural killer (NK), and T and B-lymphocytes. Interestingly, a population of immune cells that can exert both of these complex functions, NKT cells, not only share common functions bu …
Specialized cells have arisen as the sentinels of these functions, including macrophages, natural killer (NK), and T and B-lymphocyte …
Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.
Inácio AR, Liu Y, Clausen BH, Svensson M, Kucharz K, Yang Y, Stankovich T, Khorooshi R, Lambertsen KL, Issazadeh-Navikas S, Deierborg T. Inácio AR, et al. J Neuroinflammation. 2015 Nov 18;12:211. doi: 10.1186/s12974-015-0427-0. J Neuroinflammation. 2015. PMID: 26581581 Free PMC article.
Concomitantly, in the blood of IFN-betaKO mice, we found a higher percentage of total B cells but a similar percentage of mature and activated B cells, collectively indicating a higher proliferation rate. ...
Concomitantly, in the blood of IFN-betaKO mice, we found a higher percentage of total B cells but a similar percentage of mature and …
Response to microtubule-interacting agents in primary epithelial ovarian cancer cells.
Pellicciotta I, Yang CP, Venditti CA, Goldberg GL, Shahabi S. Pellicciotta I, et al. Cancer Cell Int. 2013 Apr 10;13(1):33. doi: 10.1186/1475-2867-13-33. Cancer Cell Int. 2013. PMID: 23574945 Free PMC article.
Standard first line adjuvant chemotherapy treatments include Paclitaxel (Taxol) and platinum-based agents. Taxol, epothilone B (EpoB) and discodermolide belong to a family of anti-neoplastic agents that specifically interferes with microtubules and arrests cells in the G2/ …
Standard first line adjuvant chemotherapy treatments include Paclitaxel (Taxol) and platinum-based agents. Taxol, epothilone B (EpoB) …
Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis.
Carrión B, Liu Y, Hadi M, Lundstrom J, Christensen JR, Ammitzbøll C, Dziegiel MH, Sørensen PS, Comabella M, Montalban X, Sellebjerg F, Issazadeh-Navikas S. Carrión B, et al. Neurol Neuroimmunol Neuroinflamm. 2021 Aug 12;8(6):e1065. doi: 10.1212/NXI.0000000000001065. Print 2021 Nov. Neurol Neuroimmunol Neuroinflamm. 2021. PMID: 34385365 Free PMC article.
TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas.
Seagle BL, Yang CP, Eng KH, Dandapani M, Odunsi-Akanji O, Goldberg GL, Odunsi K, Horwitz SB, Shahabi S. Seagle BL, et al. Gynecol Oncol. 2015 Jul;138(1):159-64. doi: 10.1016/j.ygyno.2015.04.039. Epub 2015 May 6. Gynecol Oncol. 2015. PMID: 25958320 Free PMC article.
METHODS: Growth inhibition of OCCs transfected with a HSM (m175, m248 or m273) was measured during treatment with paclitaxel, epothilone B (epoB), or ixabepilone. Effects of epoB on p53 expression, phosphorylation, and acetylation, as well as p53-regulated expression of p2 …
METHODS: Growth inhibition of OCCs transfected with a HSM (m175, m248 or m273) was measured during treatment with paclitaxel, epothilone …
Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis.
Montuschi P, Lucidi V, Paris D, Montemitro E, Shohreh R, Mores N, Melck D, Santini G, Majo F, Motta A. Montuschi P, et al. Front Pharmacol. 2018 Jun 18;9:595. doi: 10.3389/fphar.2018.00595. eCollection 2018. Front Pharmacol. 2018. PMID: 29967580 Free PMC article.
In CF patients who were on maintenance treatment with oral vitamin E (200 UI once daily), treatment with oral azithromycin (250 or 500 mg depending on body weight) plus vitamin E (400 UI once daily) (group A) (n = 24) or oral vitamin E alone (400 UI once daily) (group B) ( …
In CF patients who were on maintenance treatment with oral vitamin E (200 UI once daily), treatment with oral azithromycin (250 or 500 mg de …
HIV-1 regulatory protein tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif.
Kundu M, Ansari SA, Chepenik LG, Pomerantz RJ, Khalili K, Rappaport J, Amini S. Kundu M, et al. J Hum Virol. 1999 Mar-Apr;2(2):72-80. J Hum Virol. 1999. PMID: 10225209
A combination of GST pull-down assays and RNA binding studies demonstrates that the 50-kd protein interacts with both Tat and TAR and is likely to be NF-kappa B p50. CONCLUSIONS: Taken together, these data suggest that in the absence of a functional Tat binding site such a …
A combination of GST pull-down assays and RNA binding studies demonstrates that the 50-kd protein interacts with both Tat and TAR and is lik …