Cutaneous T cell lymphoma atlas reveals malignant T(H)2 cells supported by a B cell-rich tumor microenvironment.
Li R, Strobl J, Poyner EFM, Balbaa A, Torabi F, Mazin PV, Chipampe NJ, Stephenson E, Ramírez-Suástegi C, Shanmugiah VBM, Gardner L, Olabi B, Coulthard R, Botting RA, Zila N, Prigmore E, Gopee NH, Chroscik MA, Kritikaki E, Engelbert J, Goh I, Chan HM, Johnson HF, Ellis J, Rowe V, Tun W, Reynolds G, Yang D, Foster AR, Gambardella L, Winheim E, Admane C, Rumney B, Steele L, Jardine L, Nenonen J, Pickard K, Lumley J, Hampton P, Hu S, Liu F, Liu X, Horsfall D, Basurto-Lozada D, Grimble L, Bacon CM, Weatherhead SC, Brauner H, Wang Y, Bai F, Reynolds NJ, Allen JE, Jonak C, Brunner PM, Teichmann SA, Haniffa M.
Li R, et al.
Nat Immunol. 2024 Dec;25(12):2320-2330. doi: 10.1038/s41590-024-02018-1. Epub 2024 Nov 18.
Nat Immunol. 2024.
PMID: 39558094
Free PMC article.
CTCL tumor cells are spatially associated with B cells, forming tertiary lymphoid structure-like aggregates. Finally, we validated the enrichment of B cells in CTCL and its association with disease progression across three independent patient cohorts. ...
CTCL tumor cells are spatially associated with B cells, forming tertiary lymphoid structure-like aggregates. Finally, we validated th …