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Year Number of Results
2001 1
2007 1
2008 1
2009 1
2010 1
2011 1
2012 4
2013 3
2014 3
2015 9
2016 4
2017 8
2018 5
2019 11
2020 5
2021 15
2022 9
2023 12
2024 2

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87 results

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Page 1
MiR-146a/b: a family with shared seeds and different roots.
Paterson MR, Kriegel AJ. Paterson MR, et al. Physiol Genomics. 2017 Apr 1;49(4):243-252. doi: 10.1152/physiolgenomics.00133.2016. Epub 2017 Feb 17. Physiol Genomics. 2017. PMID: 28213571 Free PMC article. Review.
Nevertheless, the published literature is confounded by unclear and imprecise language concerning the specific effects of the two miR-146 family members. The present review will compare the genomic origin and regulation of miR-146a and miR-146b, discuss some …
Nevertheless, the published literature is confounded by unclear and imprecise language concerning the specific effects of the two miR
miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction.
Ke X, He L, Wang R, Shen J, Wang Z, Shen Y, Fan L, Shao J, Qi H. Ke X, et al. Front Oncol. 2021 Aug 23;11:699004. doi: 10.3389/fonc.2021.699004. eCollection 2021. Front Oncol. 2021. PMID: 34497759 Free PMC article.
Moreover, miR-377-3p was strongly enhanced by BPDE/B[a]P exposure and crucial for the inhibition of EGR1 expression by targeting the 3'UTR of EGR1. MiR-377-3p antagomir reversed the effect of EGR1 downregulation in cell malignant transformation and tumor init …
Moreover, miR-377-3p was strongly enhanced by BPDE/B[a]P exposure and crucial for the inhibition of EGR1 expression by targeti …
GSDMD-miR-223-NLRP3 axis involved in B(a)P-induced inflammatory injury of alveolar epithelial cells.
Kong X, Gao M, Liu Y, Zhang P, Li M, Ma P, Shang P, Wang W, Liu H, Zhang Q, Feng F. Kong X, et al. Ecotoxicol Environ Saf. 2022 Mar 1;232:113286. doi: 10.1016/j.ecoenv.2022.113286. Epub 2022 Feb 7. Ecotoxicol Environ Saf. 2022. PMID: 35144130 Free article.
Then, the change of inflammatory injury and activation of NLRP3 inflammasomes in B(a)P-induced A549 cells were detected after inhibiting of GSDMD or miR-223 using siRNA-GSDMD (siGSDMD) or miR-223 inhibitor, respectively. ...In conclusion, GSDMD may regulate N …
Then, the change of inflammatory injury and activation of NLRP3 inflammasomes in B(a)P-induced A549 cells were detected after inhibit …
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
Patel SP, Othus M, Chen Y, Wright GP Jr, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A. Patel SP, et al. N Engl J Med. 2023 Mar 2;388(9):813-823. doi: 10.1056/NEJMoa2211437. N Engl J Med. 2023. PMID: 36856617 Free PMC article. Clinical Trial.
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M,… See abstract for full author list ➔ Bellenguez C, et al. Nat Genet. 2022 Apr;54(4):412-436. doi: 10.1038/s41588-022-01024-z. Epub 2022 Apr 4. Nat Genet. 2022. PMID: 35379992 Free PMC article.
miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster.
Sweat Y, Ries RJ, Sweat M, Su D, Shao F, Eliason S, Amendt BA. Sweat Y, et al. Mol Ther Nucleic Acids. 2021 Oct 21;26:1148-1158. doi: 10.1016/j.omtn.2021.10.021. eCollection 2021 Dec 3. Mol Ther Nucleic Acids. 2021. PMID: 34853714 Free PMC article.
Surprisingly, miR-17 inhibition increased expression of the miR-17-92 cluster and significantly increased the levels of the miR-18a and miR-19a mature miRs. miR-17 inhibition increased expression of the cell cycle activator CCND2, associated wit …
Surprisingly, miR-17 inhibition increased expression of the miR-17-92 cluster and significantly increased the levels of the …
ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation.
Tian Z, Hua X, Zhu J, Li P, Chen R, Li X, Li T, Zhou C, Huang C. Tian Z, et al. Ecotoxicol Environ Saf. 2023 Sep 15;263:115273. doi: 10.1016/j.ecoenv.2023.115273. Epub 2023 Jul 20. Ecotoxicol Environ Saf. 2023. PMID: 37480691 Free article.
ATG7 is an E1-like activating enzyme and contributes to activating autophagic responses in mammal cells. However, the potential alterations of ATG7 and its role in B[a]PDE-caused lung carcinogenesis remain unknown. Here, we found that B[a]PDE exposure promoted ATG7 …
ATG7 is an E1-like activating enzyme and contributes to activating autophagic responses in mammal cells. However, the potential alterations …
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Huang H, Pan X, Jin H, Li Y, Zhang L, Yang C, Liu P, Liu Y, Chen L, Li J, Zhu J, Zeng X, Fu K, Chen G, Gao J, Huang C. Huang H, et al. Clin Cancer Res. 2015 Aug 15;21(16):3783-93. doi: 10.1158/1078-0432.CCR-14-2829. Epub 2015 May 14. Clin Cancer Res. 2015. PMID: 25977341 Free PMC article.
PURPOSE: The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. ...CONCLUSIONS: Our studies not only first ti …
PURPOSE: The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms r …
The functional analysis of transiently upregulated miR-101 suggests a "braking" regulatory mechanism during myogenesis.
Liu S, Xie S, Chen H, Li B, Chen Z, Tan Y, Yang J, Zheng L, Xiao Z, Zhang Q, Qu L. Liu S, et al. Sci China Life Sci. 2021 Oct;64(10):1612-1623. doi: 10.1007/s11427-020-1856-5. Epub 2021 Jan 27. Sci China Life Sci. 2021. PMID: 33521860
The overexpression of miR-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK, Interferon Gamma, and Wnt pathways and enhancing the C/EBP pathway. Mef2a, a key protein in the p38/MAPK pathway, was identified as a direct target of miR-101a/ …
The overexpression of miR-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK, Interferon Gamma, and Wnt path …
Benzo[a]pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades.
Ge Y, Gu P, Wang W, Cao L, Zhang L, Li J, Mu W, Wang H. Ge Y, et al. J Mol Cell Biol. 2021 Aug 27;13(8):556-64. doi: 10.1093/jmcb/mjab052. Online ahead of print. J Mol Cell Biol. 2021. PMID: 34450627 Free PMC article.
The epidemiological studies suggest that both environmental risk factors and chronic liver injury including NAFL are important for HCC development, but the precise mechanisms linking eating habits to hepato-carcinogenesis remain unclear. In the present study, we demonstrated that …
The epidemiological studies suggest that both environmental risk factors and chronic liver injury including NAFL are important for HCC devel …
87 results