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Proteome-wide covalent ligand discovery in native biological systems.

Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. Backus KM, et al. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15. Nature. 2016. PMID: 27309814 Free PMC article.

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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Bar-Peled L, et al. Among authors: backus km. Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28. Cell. 2017. PMID: 28965760 Free PMC article.

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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr. Briggs KJ, et al. Among authors: backus km. Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042. Cell. 2016. PMID: 27368101 Free PMC article.

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New approaches to target RNA binding proteins.

Julio AR, Backus KM. Julio AR, et al. Among authors: backus km. Curr Opin Chem Biol. 2021 Jun;62:13-23. doi: 10.1016/j.cbpa.2020.12.006. Epub 2021 Jan 31. Curr Opin Chem Biol. 2021. PMID: 33535093 Free PMC article. Review.

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Applications of Reactive Cysteine Profiling.

Backus KM. Backus KM. Curr Top Microbiol Immunol. 2019;420:375-417. doi: 10.1007/82_2018_120. Curr Top Microbiol Immunol. 2019. PMID: 30105421 Review.

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Photoaffinity labelling strategies for mapping the small molecule-protein interactome.

Burton NR, Kim P, Backus KM. Burton NR, et al. Among authors: backus km. Org Biomol Chem. 2021 Sep 22;19(36):7792-7809. doi: 10.1039/d1ob01353j. Org Biomol Chem. 2021. PMID: 34549230 Review.

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Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling.

Cao J, Boatner LM, Desai HS, Burton NR, Armenta E, Chan NJ, Castellón JO, Backus KM. Cao J, et al. Among authors: backus km. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20. Anal Chem. 2021. PMID: 33470097 Free PMC article.

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SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*.

Yan T, Desai HS, Boatner LM, Yen SL, Cao J, Palafox MF, Jami-Alahmadi Y, Backus KM. Yan T, et al. Among authors: backus km. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Chembiochem. 2021. PMID: 33442901 Free PMC article.

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Opportunities and challenges for the development of covalent chemical immunomodulators.

Backus KM, Cao J, Maddox SM. Backus KM, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3421-3439. doi: 10.1016/j.bmc.2019.05.050. Epub 2019 Jun 5. Bioorg Med Chem. 2019. PMID: 31204229 Review.

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Covalent Modulators of the Vacuolar ATPase.

Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Chen YC, et al. Among authors: backus km. J Am Chem Soc. 2017 Jan 18;139(2):639-642. doi: 10.1021/jacs.6b12511. Epub 2016 Dec 30. J Am Chem Soc. 2017. PMID: 28010062 Free PMC article.

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