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1999 1
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75 results

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Page 1
Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization.
Mohan N, Johnson GS, Tovar Perez JE, Dashwood WM, Rajendran P, Dashwood RH. Mohan N, et al. Cell Death Dis. 2024 Aug 7;15(8):570. doi: 10.1038/s41419-024-06954-6. Cell Death Dis. 2024. PMID: 39112459 Free PMC article.
Bromodomain Adjacent to Zinc Finger Domain 1A (BAZ1A) is a critical regulator of chromatin remodeling. We sought to clarify the roles of BAZ1A in the etiology of colorectal cancer, including the mechanisms of its alternatively spliced variants. ...The corresponding …
Bromodomain Adjacent to Zinc Finger Domain 1A (BAZ1A) is a critical regulator of chromatin remodeling. We sought to clarify the roles …
USP10 stabilizes BAZ1A to drive tumor stemness via an epigenetic mechanism in head and neck squamous cell carcinoma.
Shi Y, Ding J, Ling X, Xu D, Shen Y, Qin X. Shi Y, et al. Cell Death Dis. 2025 Apr 10;16(1):270. doi: 10.1038/s41419-025-07462-x. Cell Death Dis. 2025. PMID: 40204721 Free PMC article.
Therefore, we found that USP10 relied on BAZ1A to enhance HNSCC stemness, progression, and chemotherapy resistance. The pharmacology research implicated that BAZ1A-IN-1, one specific BAZ1A inhibitor, could effectively inhibit HNSCC stemness, distal metastasis …
Therefore, we found that USP10 relied on BAZ1A to enhance HNSCC stemness, progression, and chemotherapy resistance. The pharmacology …
Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation.
Yang Z, Zhou Y, Zhong L. Yang Z, et al. Bioorg Med Chem Lett. 2021 Feb 1;33:127745. doi: 10.1016/j.bmcl.2020.127745. Epub 2020 Dec 15. Bioorg Med Chem Lett. 2021. PMID: 33333161
However, there is no BAZ1A inhibitor reported so far. In this study, we used a consensus docking/scoring strategy to screen for BAZ1A bromodomain inhibitors from commercial chemical libraries and an in-house chemical database. ...Overall, we discovered a number of …
However, there is no BAZ1A inhibitor reported so far. In this study, we used a consensus docking/scoring strategy to screen for BA …
Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Prakash Yadav R, Leskinen S, Ma L, Mäkelä JA, Kotaja N. Prakash Yadav R, et al. Reproduction. 2022 Dec 2;165(1):49-63. doi: 10.1530/REP-22-0240. Print 2023 Jan 1. Reproduction. 2022. PMID: 36194437 Free PMC article.
To shed light on the heterochromatin regulation in the male germline, we studied the expression, localization and heterochromatin association of selected testis-enriched chromatin regulators in the mouse testis. Our results show that HELLS, WDHD1 and BAZ1A are dynamically …
To shed light on the heterochromatin regulation in the male germline, we studied the expression, localization and heterochromatin associatio …
Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells.
Li X, Ding D, Yao J, Zhou B, Shen T, Qi Y, Ni T, Wei G. Li X, et al. Life Sci. 2019 Jul 15;229:225-232. doi: 10.1016/j.lfs.2019.05.023. Epub 2019 May 11. Life Sci. 2019. PMID: 31085244
We aim to investigate the functional role of BAZ1A in regulating senescence in cancer and normal cells. MATERIALS AND METHODS: Knockdown of BAZ1A was performed via lentivirus mediated short hairpin RNA (shRNA) in various cancer cell lines (A549 and U2OS) and normal …
We aim to investigate the functional role of BAZ1A in regulating senescence in cancer and normal cells. MATERIALS AND METHODS: Knockd …
Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair.
Koyauchi T, Niida H, Motegi A, Sakai S, Uchida C, Ohhata T, Iijima K, Yokoyama A, Suda T, Kitagawa M. Koyauchi T, et al. Biochim Biophys Acta Mol Cell Res. 2022 Nov;1869(11):119332. doi: 10.1016/j.bbamcr.2022.119332. Epub 2022 Aug 5. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35940372 Free article.
Furthermore, MLL1 catalyzed histone H3K4 methylation and recruited the chromatin remodeler bromodomain adjacent to zinc finger domain 1A (BAZ1A)/ATP-utilizing chromatin assembly and remodeling factor 1 (ACF1). Depletion of MLL1 suppressed BAZ1A accumulation at UV-ir …
Furthermore, MLL1 catalyzed histone H3K4 methylation and recruited the chromatin remodeler bromodomain adjacent to zinc finger domain 1A ( …
Non-canonical reader modules of BAZ1A promote recovery from DNA damage.
Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM, Bai T, Zhang J, Ciferri C, Cochran AG. Oppikofer M, et al. Nat Commun. 2017 Oct 11;8(1):862. doi: 10.1038/s41467-017-00866-0. Nat Commun. 2017. PMID: 29021563 Free PMC article.
However, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to direct the ATPase SMARCA5. Here, we find that the plant homeodomain of BAZ1A, but not that of BAZ1B, has the unusual function of binding DNA. Further …
However, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to direct the ATPas …
Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine.
Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Wright KN, Mouzon E, Kabbaj M, Neve R, Turecki G, Shen L, Nestler EJ. Sun H, et al. Neuroscience. 2017 Jun 14;353:1-6. doi: 10.1016/j.neuroscience.2017.04.007. Epub 2017 Apr 12. Neuroscience. 2017. PMID: 28412501 Free PMC article.
Chromatin regulation, in particular ATP-dependent chromatin remodelers, have previously been shown to be important in the regulation of reward-related behaviors in animal models of mental illnesses. Here we demonstrate that BAZ1A, an accessory subunit of the ISWI family of …
Chromatin regulation, in particular ATP-dependent chromatin remodelers, have previously been shown to be important in the regulation of rewa …
African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.
Siddappa M, Hussain S, Wani SA, White J, Tang H, Gray JS, Jafari H, Wu HC, Long MD, Elhussin I, Karanam B, Wang H, Morgan R, Hardiman G, Adelani IB, Rotimi SO, Murphy AR, Nonn L, Davis MB, Kittles RA, Hughes Halbert C, Sucheston-Campbell LE, Yates C, Campbell MJ. Siddappa M, et al. Cancer Res Commun. 2023 Apr 18;3(4):621-639. doi: 10.1158/2767-9764.CRC-22-0389. eCollection 2023 Apr. Cancer Res Commun. 2023. PMID: 37082578 Free PMC article.
We identified reduced expression of the chromatin remodeler, BAZ1A, in three AA prostate cancer cohorts as well as RC43T compared with RC43N. Restored BAZ1A expression significantly increased 1alpha,25(OH)(2)D(3)-regulated VDR-dependent gene expression in RC43T, but …
We identified reduced expression of the chromatin remodeler, BAZ1A, in three AA prostate cancer cohorts as well as RC43T compared wit …
A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment.
Zaghlool A, Halvardson J, Zhao JJ, Etemadikhah M, Kalushkova A, Konska K, Jernberg-Wiklund H, Thuresson AC, Feuk L. Zaghlool A, et al. Hum Mutat. 2016 Sep;37(9):964-75. doi: 10.1002/humu.23034. Epub 2016 Jul 8. Hum Mutat. 2016. PMID: 27328812 Free PMC article.
Using RNA sequencing, we find that the mutation affects the expression of genes involved in several pathways including vitamin D metabolism, Wnt signaling and synaptic formation. RNA sequencing of BAZ1A knockdown cells and Baz1a knockout mice revealed that BAZ1A …
Using RNA sequencing, we find that the mutation affects the expression of genes involved in several pathways including vitamin D metabolism, …
75 results