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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2004 1
2005 1
2006 2
2007 2
2008 5
2009 2
2010 2
2011 1
2016 1
2018 1
2019 3
2020 1
2021 1
2022 1
2023 0
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22 results
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Page 1
Ligand efficiency and fragment-based drug discovery.
Bembenek SD, Tounge BA, Reynolds CH. Bembenek SD, et al. Drug Discov Today. 2009 Mar;14(5-6):278-83. doi: 10.1016/j.drudis.2008.11.007. Epub 2008 Dec 30. Drug Discov Today. 2009. PMID: 19073276 Review.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Tichenor MS, Wiener JJM, Rao NL, Bacani GM, Wei J, Pooley Deckhut C, Barbay JK, Kreutter KD, Chang L, Clancy KW, Murrey HE, Wang W, Ahn K, Huber M, Rex E, Coe KJ, Wu J, Rui H, Sepassi K, Gaudiano M, Bekkers M, Cornelissen I, Packman K, Seierstad M, Xiouras C, Bembenek SD, Alexander R, Milligan C, Balasubramanian S, Lebsack AD, Venable JD, Philippar U, Edwards JP, Hirst G. Tichenor MS, et al. Among authors: bembenek sd. J Med Chem. 2022 Nov 10;65(21):14326-14336. doi: 10.1021/acs.jmedchem.2c01026. Epub 2022 Oct 31. J Med Chem. 2022. PMID: 36314537
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Tichenor MS, Wiener JJM, Rao NL, Pooley Deckhut C, Barbay JK, Kreutter KD, Bacani GM, Wei J, Chang L, Murrey HE, Wang W, Ahn K, Huber M, Rex E, Coe KJ, Wu J, Seierstad M, Bembenek SD, Leonard KA, Lebsack AD, Venable JD, Edwards JP. Tichenor MS, et al. Among authors: bembenek sd. ACS Med Chem Lett. 2021 Apr 5;12(5):782-790. doi: 10.1021/acsmedchemlett.1c00044. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055226 Free PMC article.
D3R Grand Challenge 3: blind prediction of protein-ligand poses and affinity rankings.
Gaieb Z, Parks CD, Chiu M, Yang H, Shao C, Walters WP, Lambert MH, Nevins N, Bembenek SD, Ameriks MK, Mirzadegan T, Burley SK, Amaro RE, Gilson MK. Gaieb Z, et al. Among authors: bembenek sd. J Comput Aided Mol Des. 2019 Jan;33(1):1-18. doi: 10.1007/s10822-018-0180-4. Epub 2019 Jan 10. J Comput Aided Mol Des. 2019. PMID: 30632055 Free PMC article.
D3R grand challenge 4: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies.
Parks CD, Gaieb Z, Chiu M, Yang H, Shao C, Walters WP, Jansen JM, McGaughey G, Lewis RA, Bembenek SD, Ameriks MK, Mirzadegan T, Burley SK, Amaro RE, Gilson MK. Parks CD, et al. Among authors: bembenek sd. J Comput Aided Mol Des. 2020 Feb;34(2):99-119. doi: 10.1007/s10822-020-00289-y. Epub 2020 Jan 23. J Comput Aided Mol Des. 2020. PMID: 31974851 Free PMC article.
The role of molecular size in ligand efficiency.
Reynolds CH, Bembenek SD, Tounge BA. Reynolds CH, et al. Among authors: bembenek sd. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4258-61. doi: 10.1016/j.bmcl.2007.05.038. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17532632
Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
Rosen MD, Venkatesan H, Peltier HM, Bembenek SD, Kanelakis KC, Zhao LX, Leonard BE, Hocutt FM, Wu X, Palomino HL, Brondstetter TI, Haugh PV, Cagnon L, Yan W, Liotta LA, Young A, Mirzadegan T, Shankley NP, Barrett TD, Rabinowitz MH. Rosen MD, et al. Among authors: bembenek sd. ACS Med Chem Lett. 2010 Oct 5;1(9):526-9. doi: 10.1021/ml100198y. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900242 Free PMC article.
22 results