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The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.
Yaskolka Meir A, Keller M, Hoffmann A, Rinott E, Tsaban G, Kaplan A, Zelicha H, Hagemann T, Ceglarek U, Isermann B, Shelef I, Blüher M, Stumvoll M, Li J, Haange SB, Engelmann B, Rolle-Kampczyk U, von Bergen M, Hu FB, Stampfer MJ, Kovacs P, Liang L, Shai I. Yaskolka Meir A, et al. BMC Med. 2023 Sep 25;21(1):364. doi: 10.1186/s12916-023-03067-3. BMC Med. 2023. PMID: 37743489 Free PMC article. Clinical Trial.
The effect of polyphenol-rich dietary interventions on biological aging is yet to be determined. METHODS: We calculated different biological aging epigenetic clocks of different generations (Horvath2013, Hannum2013, Li2018, Horvath skin and blood2018, PhenoAge2018, …
The effect of polyphenol-rich dietary interventions on biological aging is yet to be determined. METHODS: We calculated different bio …
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, B Emesh T, Kovacs P, von Bergen M, Ceglarek U, Blüher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I. Kaplan A, et al. Am J Clin Nutr. 2022 May 1;115(5):1270-1281. doi: 10.1093/ajcn/nqac001. Am J Clin Nutr. 2022. PMID: 35021194 Free PMC article. Clinical Trial.
In subjects 50 y old, HOC decline and LVV expansion were attenuated in both MED groups, with the best outcomes among Green-MED diet participants, as compared with HDG (HOC: -0.8% 1.6% compared with -1.3% 1.4%; 95% CI: -1.5%, -0.02%; P = 0.042; LVV: 2.3% 4.7% compar …
In subjects 50 y old, HOC decline and LVV expansion were attenuated in both MED groups, with the best outcomes among Green-MED diet …
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies.
Almeida MF, Farizatto KLG, Almeida RS, Bahr BA. Almeida MF, et al. Ageing Res Rev. 2024 Jan;93:102162. doi: 10.1016/j.arr.2023.102162. Epub 2023 Dec 7. Ageing Res Rev. 2024. PMID: 38070831 Free PMC article. Review.
Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be influenced by life events that can positively or negatively affect age-related diseases. ...Here, we discuss life-associated vulnerabilities …
Aging is the greatest risk factor for age-related dementias such as Alzheimer's disease, and the aging process is known to be …
Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases.
Sharon N, Yarmolinsky L, Khalfin B, Fleisher-Berkovich S, Ben-Shabat S. Sharon N, et al. Int J Mol Sci. 2024 Jun 10;25(12):6402. doi: 10.3390/ijms25126402. Int J Mol Sci. 2024. PMID: 38928109 Free PMC article. Review.
Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective and anti-inflammatory features, which are fundamentally important for the treatment of neurodegenerati …
Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological …
From burden to benefit: overcoming barriers to immunization in adults, with a focus on respiratory syncytial virus.
Vicente C, Froes F, Lopalco PL, Heffernan C, Nilforooshan R, Martin F, Leroux-Roels I, Nesher L, Déplanque T, Dani N, Coelho A, Pinto de Castro N, Tayarani-Binazir K. Vicente C, et al. Expert Rev Vaccines. 2026 Dec;25(1):2684962. doi: 10.1080/14760584.2026.2684962. Epub 2026 Jun 17. Expert Rev Vaccines. 2026. PMID: 42257651 Free article. Review.
We explore barriers to adult vaccine uptake - including limited awareness, lack of reimbursement, mistrust, misinformation, and inconsistent guidance - and highlight broader benefits of adult immunization, including reducing antimicrobial resistance and promoting healthy aging …
We explore barriers to adult vaccine uptake - including limited awareness, lack of reimbursement, mistrust, misinformation, and inconsistent …
Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.
Puscheck EE, Bolnick A, Awonuga A, Yang Y, Abdulhasan M, Li Q, Secor E, Louden E, Hüttemann M, Rappolee DA. Puscheck EE, et al. J Assist Reprod Genet. 2018 Aug;35(8):1359-1366. doi: 10.1007/s10815-018-1213-6. Epub 2018 Jun 7. J Assist Reprod Genet. 2018. PMID: 29882092 Free PMC article. Review.
We here discuss and analyze data that leads to two possible conclusions: First, although DS and drugs that have some of their therapeutic mechanisms mediated by AMPK activity associated with low ATP levels, some of the associated health problems in vivo and in vitro fertilization …
We here discuss and analyze data that leads to two possible conclusions: First, although DS and drugs that have some of their therapeutic me …
Assessing data gathering of chatbot based symptom checkers - a clinical vignettes study.
Ben-Shabat N, Sharvit G, Meimis B, Ben Joya D, Sloma A, Kiderman D, Shabat A, Tsur AM, Watad A, Amital H. Ben-Shabat N, et al. Int J Med Inform. 2022 Dec;168:104897. doi: 10.1016/j.ijmedinf.2022.104897. Epub 2022 Oct 22. Int J Med Inform. 2022. PMID: 36306653 Free PMC article.
BACKGROUND: The burden on healthcare systems is mounting continuously owing to population growth and aging, overuse of medical services, and the recent COVID-19 pandemic. This overload is also causing reduced healthcare quality and outcomes. ...From among the tools availab …
BACKGROUND: The burden on healthcare systems is mounting continuously owing to population growth and aging, overuse of medical servic …
Direct and Indirect Predictors of Medication Adherence With Bipolar Disorder: Path Analysis.
Cohen B, Sixsmith A, Pollock Star A, Haglili O, O'Rourke N. Cohen B, et al. JMIR Form Res. 2023 Feb 7;7:e44059. doi: 10.2196/44059. JMIR Form Res. 2023. PMID: 36749623 Free PMC article.
BACKGROUND: Despite the efficacy of treatment and severity of symptoms, medication adherence by many with bipolar disorder (BD) is variable at best. This poses a significant challenge for BD care management. OBJECTIVE: For this study, we set out to identify psychosocial an …
BACKGROUND: Despite the efficacy of treatment and severity of symptoms, medication adherence by many with bipolar disorder (BD) is variable …
Probing the audience of seniors' online communities.
Nimrod G. Nimrod G. J Gerontol B Psychol Sci Soc Sci. 2013 Sep;68(5):773-82. doi: 10.1093/geronb/gbt059. Epub 2013 Jul 3. J Gerontol B Psychol Sci Soc Sci. 2013. PMID: 23825052
The socializers were those who reported the highest level of gratification. The aging-oriented reported more "companionship" than the information swappers, and the latter reported more "joyfulness" than the aging-oriented. CONCLUSIONS: The results suggested that mem …
The socializers were those who reported the highest level of gratification. The aging-oriented reported more "companionship" than the …
21 results