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Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.
Murugaiyan J, Rockstroh M, Wagner J, Baumann S, Schorsch K, Trump S, Lehmann I, Bergen Mv, Tomm JM. Murugaiyan J, et al. Among authors: bergen mv. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):307-16. doi: 10.1016/j.taap.2013.03.032. Epub 2013 Apr 10. Toxicol Appl Pharmacol. 2013. PMID: 23583300