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Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: blackburn hn. Nature. 2022 Jun;606(7914):585-593. doi: 10.1038/s41586-022-04802-1. Epub 2022 Apr 28. Nature. 2022. PMID: 35483404 Free PMC article.
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Roulis M, et al. Among authors: blackburn hn. Nature. 2020 Apr;580(7804):524-529. doi: 10.1038/s41586-020-2166-3. Epub 2020 Apr 1. Nature. 2020. PMID: 32322056 Free PMC article.
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory.
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. Micevic G, et al. Among authors: blackburn hn. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2304319120. doi: 10.1073/pnas.2304319120. Epub 2023 Jul 17. Proc Natl Acad Sci U S A. 2023. PMID: 37459511 Free PMC article.
Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: blackburn hn. bioRxiv [Preprint]. 2022 Apr 1:2021.09.27.461948. doi: 10.1101/2021.09.27.461948. bioRxiv. 2022. Update in: Nature. 2022 Jun;606(7914):585-593. doi: 10.1038/s41586-022-04802-1. PMID: 34611663 Free PMC article. Updated. Preprint.
Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1.
Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Amezcua Vesely MC, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. Shin JH, et al. Among authors: blackburn hn. iScience. 2021 Apr 15;24(5):102411. doi: 10.1016/j.isci.2021.102411. eCollection 2021 May 21. iScience. 2021. PMID: 33997693 Free PMC article.