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A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge.
Hill H, Mitsi E, Nikolaou E, Blizard A, Pojar S, Howard A, Hyder-Wright A, Devin J, Reiné J, Robinson R, Solórzano C, Jochems SP, Kenny-Nyazika T, Ramos-Sevillano E, Weight CM, Myerscough C, McLenaghan D, Morton B, Gibbons E, Farrar M, Randles V, Burhan H, Chen T, Shandling AD, Campo JJ, Heyderman RS, Gordon SB, Brown JS, Collins AM, Ferreira DM. Hill H, et al. Among authors: blizard a. Am J Respir Crit Care Med. 2023 Oct 15;208(8):868-878. doi: 10.1164/rccm.202302-0222OC. Am J Respir Crit Care Med. 2023. PMID: 37556679 Clinical Trial.
Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults.
Nikolaou E, Jochems SP, Mitsi E, Pojar S, Blizard A, Reiné J, Solórzano C, Negera E, Carniel B, Soares-Schanoski A, Connor V, Adler H, Zaidi SR, Hales C, Hill H, Hyder-Wright A, Gordon SB, Rylance J, Ferreira DM. Nikolaou E, et al. Among authors: blizard a. mBio. 2021 Jan 12;12(1):e02020-20. doi: 10.1128/mBio.02020-20. mBio. 2021. PMID: 33436429 Free PMC article.
The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.
Nikolaou E, German EL, Blizard A, Howard A, Hitchins L, Chen T, Chadwick J, Pojar S, Mitsi E, Solórzano C, Sunny S, Dunne F, Gritzfeld JF, Adler H, Hinds J, Gould KA, Rylance J, Collins AM, Gordon SB, Ferreira DM. Nikolaou E, et al. Among authors: blizard a. Sci Rep. 2021 Sep 14;11(1):18279. doi: 10.1038/s41598-021-97807-1. Sci Rep. 2021. PMID: 34521967 Free PMC article.