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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.
Boretto M, Maenhoudt N, Luo X, Hennes A, Boeckx B, Bui B, Heremans R, Perneel L, Kobayashi H, Van Zundert I, Brems H, Cox B, Ferrante M, Uji-I H, Koh KP, D'Hooghe T, Vanhie A, Vergote I, Meuleman C, Tomassetti C, Lambrechts D, Vriens J, Timmerman D, Vankelecom H. Boretto M, et al. Nat Cell Biol. 2019 Aug;21(8):1041-1051. doi: 10.1038/s41556-019-0360-z. Epub 2019 Aug 1. Nat Cell Biol. 2019. PMID: 31371824
Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models.
Maenhoudt N, Defraye C, Boretto M, Jan Z, Heremans R, Boeckx B, Hermans F, Arijs I, Cox B, Van Nieuwenhuysen E, Vergote I, Van Rompuy AS, Lambrechts D, Timmerman D, Vankelecom H. Maenhoudt N, et al. Among authors: boretto m. Stem Cell Reports. 2020 Apr 14;14(4):717-729. doi: 10.1016/j.stemcr.2020.03.004. Epub 2020 Apr 2. Stem Cell Reports. 2020. PMID: 32243841 Free PMC article.
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.
Geurts MH, Gandhi S, Boretto MG, Akkerman N, Derks LLM, van Son G, Celotti M, Harshuk-Shabso S, Peci F, Begthel H, Hendriks D, Schürmann P, Andersson-Rolf A, Chuva de Sousa Lopes SM, van Es JH, van Boxtel R, Clevers H. Geurts MH, et al. Among authors: boretto mg. Nat Commun. 2023 Aug 17;14(1):4998. doi: 10.1038/s41467-023-40701-3. Nat Commun. 2023. PMID: 37591832 Free PMC article.
Rapid tissue prototyping with micro-organospheres.
Wang Z, Boretto M, Millen R, Natesh N, Reckzeh ES, Hsu C, Negrete M, Yao H, Quayle W, Heaton BE, Harding AT, Bose S, Driehuis E, Beumer J, Rivera GO, van Ineveld RL, Gex D, DeVilla J, Wang D, Puschhof J, Geurts MH, Yeung A, Hamele C, Smith A, Bankaitis E, Xiang K, Ding S, Nelson D, Delubac D, Rios A, Abi-Hachem R, Jang D, Goldstein BJ, Glass C, Heaton NS, Hsu D, Clevers H, Shen X. Wang Z, et al. Among authors: boretto m. Stem Cell Reports. 2022 Sep 13;17(9):1959-1975. doi: 10.1016/j.stemcr.2022.07.016. Epub 2022 Aug 18. Stem Cell Reports. 2022. PMID: 35985334 Free PMC article.
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7.
Boretto M, Geurts MH, Gandhi S, Ma Z, Staliarova N, Celotti M, Lim S, He GW, Millen R, Driehuis E, Begthel H, Smabers L, Roodhart J, van Es J, Wu W, Clevers H. Boretto M, et al. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2309902121. doi: 10.1073/pnas.2309902121. Epub 2024 Mar 14. Proc Natl Acad Sci U S A. 2024. PMID: 38483988 Free PMC article.
Human-Derived Model Systems in Gynecological Cancer Research.
Lõhmussaar K, Boretto M, Clevers H. Lõhmussaar K, et al. Among authors: boretto m. Trends Cancer. 2020 Dec;6(12):1031-1043. doi: 10.1016/j.trecan.2020.07.007. Epub 2020 Aug 24. Trends Cancer. 2020. PMID: 32855097 Free article. Review.
Murine Endometrial Organoids to Model Chlamydia Infection.
Bishop RC, Boretto M, Rutkowski MR, Vankelecom H, Derré I. Bishop RC, et al. Among authors: boretto m. Front Cell Infect Microbiol. 2020 Aug 14;10:416. doi: 10.3389/fcimb.2020.00416. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32923409 Free PMC article.
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.
Geurts MH, de Poel E, Pleguezuelos-Manzano C, Oka R, Carrillo L, Andersson-Rolf A, Boretto M, Brunsveld JE, van Boxtel R, Beekman JM, Clevers H. Geurts MH, et al. Among authors: boretto m. Life Sci Alliance. 2021 Aug 9;4(10):e202000940. doi: 10.26508/lsa.202000940. Print 2021 Oct. Life Sci Alliance. 2021. PMID: 34373320 Free PMC article.
18 results