Search Page

1

Cite

Share

Chemical and Structural Strategies to Selectively Target mTOR Kinase.

Borsari C, De Pascale M, Wymann MP. Borsari C, et al. ChemMedChem. 2021 Sep 16;16(18):2744-2759. doi: 10.1002/cmdc.202100332. Epub 2021 Jul 1. ChemMedChem. 2021. PMID: 34114360 Free PMC article. Review.

Cite

Share

2

Cite

Share

Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids.

Magoulas GE, Afroudakis P, Georgikopoulou K, Roussaki M, Borsari C, Fotopoulou T, Santarem N, Barrias E, Tejera Nevado P, Hachenberg J, Bifeld E, Ellinger B, Kuzikov M, Fragiadaki I, Scoulica E, Clos J, Gul S, Costi MP, de Souza W, Prousis KC, Cordeiro da Silva A, Calogeropoulou T. Magoulas GE, et al. Among authors: borsari c. Molecules. 2021 Jul 10;26(14):4204. doi: 10.3390/molecules26144204. Molecules. 2021. PMID: 34299479 Free PMC article.

Cite

Share

3

Cite

Share

Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability.

Borsari C, Keles E, Treyer A, De Pascale M, Hebeisen P, Hamburger M, Wymann MP. Borsari C, et al. RSC Med Chem. 2021 Jan 12;12(4):579-583. doi: 10.1039/d0md00408a. RSC Med Chem. 2021. PMID: 34041490 Free PMC article.

Cite

Share

4

Cite

Share

Targeting Phosphoinositide 3-Kinase - Five Decades of Chemical Space Exploration.

Borsari C, Wymann MP. Borsari C, et al. Chimia (Aarau). 2021 Dec 22;75(12):1037-1044. doi: 10.2533/chimia.2021.1037. Chimia (Aarau). 2021. PMID: 34920774

Cite

Share

5

Cite

Share

Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.

Borsari C, Trader DJ, Tait A, Costi MP. Borsari C, et al. J Med Chem. 2020 Mar 12;63(5):1908-1928. doi: 10.1021/acs.jmedchem.9b01456. Epub 2020 Feb 19. J Med Chem. 2020. PMID: 32023055 Free PMC article. Review.

Cite

Share

6

Cite

Share

Target-based approaches for the discovery of new antimycobacterial drugs.

Borsari C, Ferrari S, Venturelli A, Costi MP. Borsari C, et al. Drug Discov Today. 2017 Mar;22(3):576-584. doi: 10.1016/j.drudis.2016.11.014. Epub 2016 Nov 23. Drug Discov Today. 2017. PMID: 27890671 Review.

Cite

Share

7

Cite

Share

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.

Rathinaswamy MK, Gaieb Z, Fleming KD, Borsari C, Harris NJ, Moeller BE, Wymann MP, Amaro RE, Burke JE. Rathinaswamy MK, et al. Among authors: borsari c. Elife. 2021 Mar 4;10:e64691. doi: 10.7554/eLife.64691. Elife. 2021. PMID: 33661099 Free PMC article.

Cite

Share

8

Cite

Share

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno Dos Santos P, Alcântara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP. Borsari C, et al. Eur J Med Chem. 2017 Jan 27;126:1129-1135. doi: 10.1016/j.ejmech.2016.12.017. Epub 2016 Dec 9. Eur J Med Chem. 2017. PMID: 28064141

Cite

Share

9

Cite

Share

Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents.

Franchini S, Linciano P, Puja G, Tait A, Borsari C, Denora N, Iacobazzi RM, Brasili L, Sorbi C. Franchini S, et al. Among authors: borsari c. ACS Med Chem Lett. 2020 Apr 3;11(5):1028-1034. doi: 10.1021/acsmedchemlett.0c00129. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435421 Free PMC article.

Cite

Share

10

Cite

Share

4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.

Borsari C, Keles E, Rageot D, Treyer A, Bohnacker T, Bissegger L, De Pascale M, Melone A, Sriramaratnam R, Beaufils F, Hamburger M, Hebeisen P, Löscher W, Fabbro D, Hillmann P, Wymann MP. Borsari C, et al. J Med Chem. 2020 Nov 25;63(22):13595-13617. doi: 10.1021/acs.jmedchem.0c00620. Epub 2020 Nov 9. J Med Chem. 2020. PMID: 33166139 Free article.

Cite

Share