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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.

Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K. Coll RC, et al. Among authors: boucher d. Nat Chem Biol. 2019 Jun;15(6):556-559. doi: 10.1038/s41589-019-0277-7. Epub 2019 May 13. Nat Chem Biol. 2019. PMID: 31086327

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Microbial markers in colorectal cancer detection and/or prognosis.

Villéger R, Lopès A, Veziant J, Gagnière J, Barnich N, Billard E, Boucher D, Bonnet M. Villéger R, et al. Among authors: boucher d. World J Gastroenterol. 2018 Jun 14;24(22):2327-2347. doi: 10.3748/wjg.v24.i22.2327. World J Gastroenterol. 2018. PMID: 29904241 Free PMC article. Review.

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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K. Boucher D, et al. J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6. J Exp Med. 2018. PMID: 29432122 Free PMC article.

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Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. Chen KW, et al. Among authors: boucher d. Sci Immunol. 2018 Aug 24;3(26):eaar6676. doi: 10.1126/sciimmunol.aar6676. Sci Immunol. 2018. PMID: 30143554

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Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.

Santos JC, Boucher D, Schneider LK, Demarco B, Dilucca M, Shkarina K, Heilig R, Chen KW, Lim RYH, Broz P. Santos JC, et al. Among authors: boucher d. Nat Commun. 2020 Jun 24;11(1):3276. doi: 10.1038/s41467-020-16889-z. Nat Commun. 2020. PMID: 32581219 Free PMC article.

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Reply to López-Cortés et al.

Leroy AG, Corvec S, Danneels P, Dubée V, Kempf M, Boucher D, Issa N, Peuchant O, Camou F, Boutoille D, Lecomte R. Leroy AG, et al. Among authors: boucher d. Clin Infect Dis. 2021 Jan 27;72(2):361-362. doi: 10.1093/cid/ciaa517. Clin Infect Dis. 2021. PMID: 33501948 No abstract available.

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Salmonella-induced inflammasome activation in humans.

Bierschenk D, Boucher D, Schroder K. Bierschenk D, et al. Among authors: boucher d. Mol Immunol. 2017 Jun;86:38-43. doi: 10.1016/j.molimm.2016.11.009. Epub 2016 Dec 11. Mol Immunol. 2017. PMID: 27974148 Review.

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Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors.

Tang Q, Aronov AM, Deininger DD, Giroux S, Lauffer DJ, Li P, Liang J, McGinty K, Ronkin S, Swett R, Waal N, Boucher D, Ford PJ, Moody CS. Tang Q, et al. Among authors: boucher d. ACS Med Chem Lett. 2021 May 24;12(6):955-960. doi: 10.1021/acsmedchemlett.1c00094. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141080

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Reply to Lopez-Cortes, et al.

Leroy AG, Corvec S, Danneels P, Dubee V, Kempf M, Boucher D, Issa N, Peuchant O, Camou F, Boutoille D, Lecomte R. Leroy AG, et al. Among authors: boucher d. Clin Infect Dis. 2020 May 4:ciaa517. doi: 10.1093/cid/ciaa517. Online ahead of print. Clin Infect Dis. 2020. PMID: 32364225 No abstract available.

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Great balls of fire: activation and signalling of inflammatory caspases.

Bateman G, Hill B, Knight R, Boucher D. Bateman G, et al. Among authors: boucher d. Biochem Soc Trans. 2021 Jun 30;49(3):1311-1324. doi: 10.1042/BST20200986. Biochem Soc Trans. 2021. PMID: 34060593 Free PMC article. Review.

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