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54 results

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Page 1
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ. Baar MP, et al. Among authors: brandt rmc. Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031. Cell. 2017. PMID: 28340339 Free PMC article.
Genome-wide RNA polymerase stalling shapes the transcriptome during aging.
Gyenis A, Chang J, Demmers JJPG, Bruens ST, Barnhoorn S, Brandt RMC, Baar MP, Raseta M, Derks KWJ, Hoeijmakers JHJ, Pothof J. Gyenis A, et al. Among authors: brandt rmc. Nat Genet. 2023 Feb;55(2):268-279. doi: 10.1038/s41588-022-01279-6. Epub 2023 Jan 19. Nat Genet. 2023. PMID: 36658433 Free PMC article.
Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.
Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH. Vermeij WP, et al. Among authors: brandt rm. Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24. Nature. 2016. PMID: 27556946 Free PMC article.
Metabolomic analysis of dietary-restriction-induced attenuation of sarcopenia in prematurely aging DNA repair-deficient mice.
He Y, Yang W, Huang L, Mever MA, Ramautar R, Harms A, Rijksen Y, Brandt RMC, Barnhoorn S, Smit K, Jaarsma D, Lindenburg P, Hoeijmakers JHJ, Vermeij WP, Hankemeier T. He Y, et al. Among authors: brandt rmc. J Cachexia Sarcopenia Muscle. 2024 Jun;15(3):868-882. doi: 10.1002/jcsm.13433. Epub 2024 Apr 30. J Cachexia Sarcopenia Muscle. 2024. PMID: 38689513 Free PMC article.
Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1Δ /- Mice.
Stefens SJM, van der Linden J, Heredia-Genestar JM, Brandt RMC, Barnhoorn S, Nieuwenhuizen-Bakker I, van Vliet N, Odijk JHM, Ridwan Y, Stuijts D, Batenburg M, Hoeijmakers JHJ, Kanaar R, Essers J, van der Pluijm I. Stefens SJM, et al. Among authors: brandt rmc. Aging Cell. 2025 Jul;24(7):e70062. doi: 10.1111/acel.70062. Epub 2025 Apr 25. Aging Cell. 2025. PMID: 40279334 Free PMC article.
Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice.
Vermeij WP, Alyodawi K, van Galen I, von der Heide JL, Birkisdóttir MB, Van't Sant LJ, Ozinga RA, Komninos DSJ, Smit K, Rijksen YMA, Brandt RMC, Barnhoorn S, Jaarsma D, Vaiyapuri S, Ritvos O, Huber TB, Kretz O, Patel K. Vermeij WP, et al. Among authors: brandt rmc. J Cachexia Sarcopenia Muscle. 2024 Dec;15(6):2361-2374. doi: 10.1002/jcsm.13570. Epub 2024 Sep 8. J Cachexia Sarcopenia Muscle. 2024. PMID: 39245994 Free PMC article.
The current status of therapeutic HPV vaccine.
van Driel WJ, Ressing ME, Brandt RM, Toes RE, Fleuren GJ, Trimbos JB, Kast WM, Melief CJ. van Driel WJ, et al. Among authors: brandt rm. Ann Med. 1996 Dec;28(6):471-7. doi: 10.3109/07853899608999110. Ann Med. 1996. PMID: 9017105 Review.
Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.
van der Linden J, Stefens SJM, Heredia-Genestar JM, Ridwan Y, Brandt RMC, van Vliet N, de Beer I, van Thiel BS, Steen H, Cheng C, Roks AJM, Danser AHJ, Essers J, van der Pluijm I. van der Linden J, et al. Among authors: brandt rmc. Aging Cell. 2024 May;23(5):e14126. doi: 10.1111/acel.14126. Epub 2024 Mar 7. Aging Cell. 2024. PMID: 38451018 Free PMC article.
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice.
de Boer M, Te Lintel Hekkert M, Chang J, van Thiel BS, Martens L, Bos MM, de Kleijnen MGJ, Ridwan Y, Octavia Y, van Deel ED, Blonden LA, Brandt RMC, Barnhoorn S, Bautista-Niño PK, Krabbendam-Peters I, Wolswinkel R, Arshi B, Ghanbari M, Kupatt C, de Windt LJ, Danser AHJ, van der Pluijm I, Remme CA, Stoll M, Pothof J, Roks AJM, Kavousi M, Essers J, van der Velden J, Hoeijmakers JHJ, Duncker DJ. de Boer M, et al. Among authors: brandt rmc. Aging Cell. 2023 Mar;22(3):e13768. doi: 10.1111/acel.13768. Epub 2023 Feb 8. Aging Cell. 2023. PMID: 36756698 Free PMC article.
54 results