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BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.
Han D, Schaffner SH, Davies JP, Benton ML, Plate L, Nordman JT. Han D, et al. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2305092120. doi: 10.1073/pnas.2305092120. Epub 2023 Sep 18. Proc Natl Acad Sci U S A. 2023. PMID: 37722046 Free PMC article.
The underlying mechanism linking BRWD3 and H3K4 methylation, however, has yet to be defined. Here, we show that depleting BRWD3 not only causes an increase in H3K4me1 levels but also causes a decrease in H3K4me3 (H3 lysine 4 trimethylation) levels, indicating that …
The underlying mechanism linking BRWD3 and H3K4 methylation, however, has yet to be defined. Here, we show that depleting BRWD3 …
BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.
Han D, Schaffner SH, Davies JP, Lauren Benton M, Plate L, Nordman JT. Han D, et al. bioRxiv [Preprint]. 2023 Mar 28:2023.03.28.534572. doi: 10.1101/2023.03.28.534572. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2305092120. doi: 10.1073/pnas.2305092120. PMID: 37034668 Free PMC article. Updated. Preprint.
The underlying mechanism linking BRWD3 and H3K4 methylation, however, has yet to be defined. Here, we show that depleting BRWD3 not only causes an increase in H3K4me1 levels, but also causes a decrease in H3K4me3 levels, indicating that BRWD3 influences H3K4 …
The underlying mechanism linking BRWD3 and H3K4 methylation, however, has yet to be defined. Here, we show that depleting BRWD3 …
Variants in BRWD3 associated with X-linked partial epilepsy without intellectual disability.
Tian MQ, Liu XR, Lin SM, Wang J, Luo S, Gao LD, Chen XB, Liang XY, Liu ZG, He N, Yi YH, Liao WP; China Epilepsy Gene 1.0 Project. Tian MQ, et al. CNS Neurosci Ther. 2023 Feb;29(2):727-735. doi: 10.1111/cns.14057. Epub 2022 Dec 13. CNS Neurosci Ther. 2023. PMID: 36514184 Free PMC article.
Further analysis demonstrated that all previously reported destructive variants of BRWD3 caused intellectual disability, while missense variants located in WD40 repeat domains and bromodomains of BRWD3 were associated with epilepsy. ...The genotypes and locations of …
Further analysis demonstrated that all previously reported destructive variants of BRWD3 caused intellectual disability, while missen …
Further clinical and molecular characterization of an XLID syndrome associated with BRWD3 variants, a gene implicated in the leukemia-related JAK-STAT pathway.
Delanne J, Lecat M, Blackburn PR, Klee EW, Stumpel CTRM, Stegmann S, Stevens SJC, Nava C, Heron D, Keren B, Mahida S, Naidu S, Babovic-Vuksanovic D, Herkert JC, Torring PM, Kibæk M, De Bie I, Pfundt R, Hendriks YMC, Ousager LB, Bend R, Warren H, Skinner SA, Lyons MJ, Pöe C, Chevarin M, Jouan T, Garde A, Thomas Q, Kuentz P, Tisserant E, Duffourd Y, Philippe C, Faivre L, Thauvin-Robinet C. Delanne J, et al. Eur J Med Genet. 2023 Jan;66(1):104670. doi: 10.1016/j.ejmg.2022.104670. Epub 2022 Nov 19. Eur J Med Genet. 2023. PMID: 36414205 Review.
BACKGROUND: Since the first description of a BRWD3-associated nonsydromic intellectual disability (ID) disorder in 2007, 21 additional families have been reported in the literature. ...CONCLUSION: This study demonstrates that the BRWD3-related phenotypes are largely …
BACKGROUND: Since the first description of a BRWD3-associated nonsydromic intellectual disability (ID) disorder in 2007, 21 additiona …
Arsenic-induced downregulation of BRWD3 suppresses proliferation and induces apoptosis in lung adenocarcinoma cells through the p53 and p65 pathways.
Zhu Y, Xiao M, Zhao R, Yang X, Wu K, Liu X, Chen X, Guo L, Liu J, Chen X, Liu N, He Y, Zhang Y. Zhu Y, et al. Hum Exp Toxicol. 2024 Jan-Dec;43:9603271241279166. doi: 10.1177/09603271241279166. Hum Exp Toxicol. 2024. Retraction in: Hum Exp Toxicol. 2025 Jan-Dec;44:9603271251390662. doi: 10.1177/09603271251390662. PMID: 39190898 Free article. Retracted.
This study aimed to investigate BRWD3 expression in response to arsenic-induced conditions and its impact on the proliferation and apoptosis of LUAD cell line SPC-A1 upon BRWD3 knockdown. ...In conclusion, BRWD3 mediated proliferation and apoptosis via the p5 …
This study aimed to investigate BRWD3 expression in response to arsenic-induced conditions and its impact on the proliferation and ap …
MRX93 syndrome (BRWD3 gene): five new patients with novel mutations.
Tenorio J, Alarcón P, Arias P, Ramos FJ, Campistol J, Climent S, García-Miñaur S, Dapía I, Hernández A, Nevado J, Solís M, Ruiz-Pérez VL; Sogri Consortium; Lapunzina P. Tenorio J, et al. Clin Genet. 2019 Jun;95(6):726-731. doi: 10.1111/cge.13504. Epub 2019 Apr 29. Clin Genet. 2019. PMID: 30628072
In the present paper, we report five new patients (from four unrelated families) with an X-linked mental retardation syndrome with overgrowth (XMR93 syndrome), also known as XLID-BRWD3-related syndrome. The main features of these patients include ID, macrocephaly and dysmo …
In the present paper, we report five new patients (from four unrelated families) with an X-linked mental retardation syndrome with overgrowt …
Intragenic Microdeletion of ULK4 and Partial Microduplication of BRWD3 in Siblings with Neuropsychiatric Features and Obesity.
Tassano E, Uccella S, Giacomini T, Striano P, Severino M, Porta S, Gimelli G, Ronchetto P. Tassano E, et al. Cytogenet Genome Res. 2018;156(1):14-21. doi: 10.1159/000491871. Epub 2018 Aug 8. Cytogenet Genome Res. 2018. PMID: 30086552 Review.
ULK4 and BRWD3 deletions have been identified in patients with developmental/language delay and intellectual disability. ...In particular, ULK4 encodes serine/threonine kinases that are critical for the development and function of the nervous system, while BRWD3 pla …
ULK4 and BRWD3 deletions have been identified in patients with developmental/language delay and intellectual disability. ...In partic …
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ. Wang X, et al. Cell Rep. 2021 Jun 22;35(12):109281. doi: 10.1016/j.celrep.2021.109281. Cell Rep. 2021. PMID: 34161765 Free article.
Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced obesity. Although typically recognized as a component of the CUL4-RING E3 ubiquitin ligase complex, DDB1 stimulates adipogenesis independently of CUL4. ...Ddb1(+/-) mice show de …
Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced obesity. Although typically recognize …
Genomic characterization of lymphomas in patients with inborn errors of immunity.
Ye X, Maglione PJ, Wehr C, Li X, Wang Y, Abolhassani H, Deripapa E, Liu D, Borte S, Du L, Wan H, Plötner A, Giannoula Y, Ko HB, Hou Y, Zhu S, Grossman JK, Sander B, Grimbacher B, Hammarström L, Fedorova A, Rosenzweig SD, Shcherbina A, Wu K, Warnatz K, Cunningham-Rundles C, Pan-Hammarström Q. Ye X, et al. Blood Adv. 2022 Sep 27;6(18):5403-5414. doi: 10.1182/bloodadvances.2021006654. Blood Adv. 2022. PMID: 35687490 Free PMC article.
Furthermore, we profiled somatic mutations in the lymphoma genome and identified 8 genes that were mutated at a significantly higher level in IEI-associated diffuse large B-cell lymphomas (DLBCLs) than in non-IEI DLBCLs, such as BRCA2, NCOR1, KLF2, FAS, CCND3, and BRWD3. T …
Furthermore, we profiled somatic mutations in the lymphoma genome and identified 8 genes that were mutated at a significantly higher level i …
[X-linked intellectual disability syndrome with macrocephaly due to BRWD3 gene deletion].
Arroyo-Carrera I, Romero-Peguero R, Martín-Fernández R, Ramajo-Polo A, García-Navas Núñez V. Arroyo-Carrera I, et al. Rev Neurol. 2024 Jun 1;78(11):323-326. doi: 10.33588/rn.7811.2024057. Rev Neurol. 2024. PMID: 38813790 Free PMC article. Spanish.
The great majority of cases yield point variants in the gene, only three large deletions including only the BRWD3 gene have been reported. The BRWD3 protein is an epigenetic reader that regulates chromatin remodeling. ...CONCLUSIONS: Our patient confirms that the ha …
The great majority of cases yield point variants in the gene, only three large deletions including only the BRWD3 gene have been repo …
47 results