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BTN2A2, a new biomarker and therapeutic target for glioma.
Wang H, Pu S, Xu H, Yang L, Shao L, Chen X, Huang X, Pu J. Wang H, et al. Aging (Albany NY). 2023 Oct 17;15(20):10996-11011. doi: 10.18632/aging.205039. Epub 2023 Oct 17. Aging (Albany NY). 2023. PMID: 37851374 Free PMC article.
BACKGROUND: Protein casein 2A2 (BTN2A2) is a costimulatory molecule first identified in antigen-presenting cells. Studies have shown the involvement of BTN2A2 in immunity. However, the exact role and the mechanism of BTN2A2 in tumors are still unclear. METHOD …
BACKGROUND: Protein casein 2A2 (BTN2A2) is a costimulatory molecule first identified in antigen-presenting cells. Studies have shown …
Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.
Frech M, Omata Y, Schmalzl A, Wirtz S, Taher L, Schett G, Zaiss MM, Sarter K. Frech M, et al. Front Immunol. 2022 Jan 25;13:757436. doi: 10.3389/fimmu.2022.757436. eCollection 2022. Front Immunol. 2022. PMID: 35145516 Free PMC article.
We analyzed the role of Btn2a2 in the ILC-T cell cross talk. We found that the expression of Btn2a2 is upregulated in ILC2 following stimulation with IL-33/IL-25/TSLP. ...In vivo transfer experiments confirmed the regulatory role of Btn2a2 on ILC2 as Btn2a …
We analyzed the role of Btn2a2 in the ILC-T cell cross talk. We found that the expression of Btn2a2 is upregulated in ILC2 fol …
BTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice.
He X, Hu R, Luo P, Gao J, Yang W, Li J, Huang Y, Han F, Lai L, Su M. He X, et al. Sci Rep. 2021 Sep 29;11(1):19375. doi: 10.1038/s41598-021-98443-5. Sci Rep. 2021. PMID: 34588505 Free PMC article.
In this study, we investigate the ability of a recombinant BTN2A2-IgG2a Fc (BTN2A2-Ig) fusion protein to treat CIA. We show here that administration of BTN2A2-Ig attenuates established CIA, as compared with control Ig protein treatment. This is associated wit …
In this study, we investigate the ability of a recombinant BTN2A2-IgG2a Fc (BTN2A2-Ig) fusion protein to treat CIA. We show he …
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice.
Huang Y, Han F, Li J, Li Y, Gao J, Lai L, Luo P, Su M, Hu R. Huang Y, et al. Immunol Lett. 2023 Aug;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Epub 2023 Jun 25. Immunol Lett. 2023. PMID: 37369312
Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4(+)T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) …
Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4(+)T …
Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.
Frech M, Danzer H, Uchil P, Azizov V, Schmid E, Schälter F, Dürholz K, Mauro D, Rauber S, Muñoz L, Taher L, Ciccia F, Schober K, Irla M, Sarter K, Schett G, Zaiss MM. Frech M, et al. J Autoimmun. 2023 Sep;139:103071. doi: 10.1016/j.jaut.2023.103071. Epub 2023 Jun 23. J Autoimmun. 2023. PMID: 37356345 Free article.
Absence of Btn2a2 alters thymic T cell maturation and bypasses central tolerance mechanisms. Furthermore, Btn2a2(-/-) mice develop spontaneous autoimmunity resembling human primary Sjogren's Syndrome (pSS), including formation of tertiary lymphoid structures (TLS) i …
Absence of Btn2a2 alters thymic T cell maturation and bypasses central tolerance mechanisms. Furthermore, Btn2a2(-/-) mice dev …
An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumor immunity.
Xiao L, Hu R, Chen W, Gao J, Zhao Y, Wang Z, Du G, Tian Y, Lai L, Liu L, Su M. Xiao L, et al. Neoplasia. 2025 Jul;65:101161. doi: 10.1016/j.neo.2025.101161. Epub 2025 Apr 21. Neoplasia. 2025. PMID: 40262436 Free PMC article.
In this study, we have developed a novel immune checkpoint inhibitor (ICI) targeting the B7 family-related molecule BTN2A2. The human BTN2A2 protein, which was highly expressed in some tumor tissues and activated antigen-presenting cells (APCs), can inhibit T cell a …
In this study, we have developed a novel immune checkpoint inhibitor (ICI) targeting the B7 family-related molecule BTN2A2. The human …
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
Sarter K, Leimgruber E, Gobet F, Agrawal V, Dunand-Sauthier I, Barras E, Mastelic-Gavillet B, Kamath A, Fontannaz P, Guéry L, Duraes Fdo V, Lippens C, Ravn U, Santiago-Raber ML, Magistrelli G, Fischer N, Siegrist CA, Hugues S, Reith W. Sarter K, et al. J Exp Med. 2016 Feb 8;213(2):177-87. doi: 10.1084/jem.20150435. Epub 2016 Jan 25. J Exp Med. 2016. PMID: 26809444 Free PMC article.
To address this, we generated Btn2a2-deficient mice. Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyeli …
To address this, we generated Btn2a2-deficient mice. Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell res …
RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.
Frech M, Schuster G, Andes FT, Schett G, Zaiss MM, Sarter K. Frech M, et al. Front Endocrinol (Lausanne). 2021 Aug 4;12:685060. doi: 10.3389/fendo.2021.685060. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34421818 Free PMC article.
Here, we analyzed the role of one specific butyrophilin, namely Btn2a2, as we have recently shown that Btn2a2 is expressed on the monocyte/macrophage lineage that also gives rise to bone degrading osteoclasts. ...In vivo steady state CT and histological analysis of …
Here, we analyzed the role of one specific butyrophilin, namely Btn2a2, as we have recently shown that Btn2a2 is expressed on …
Frameshift mutations of immunomodulatory BTN2A1, BTN2A2, and BTNL3 genes in colon cancers.
Kim JW, Rim D, Ann CH, Lee SH. Kim JW, et al. Pathol Res Pract. 2023 Sep;249:154769. doi: 10.1016/j.prp.2023.154769. Epub 2023 Aug 23. Pathol Res Pract. 2023. PMID: 37634314
In the present study, we analyzed three butyrophilin genes, BTN2A1 (immune-stimulatory), BTN2A2 (inhibitory), and BTNL3 (stimulatory) genes in sporadic colon cancers (CCs). By the mutation analysis, we identified the frameshift mutations of BTN2A1, BTN2A2, and BTNL3 …
In the present study, we analyzed three butyrophilin genes, BTN2A1 (immune-stimulatory), BTN2A2 (inhibitory), and BTNL3 (stimulatory) …
Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Ammann JU, Cooke A, Trowsdale J. Ammann JU, et al. J Immunol. 2013 May 15;190(10):5030-6. doi: 10.4049/jimmunol.1203325. Epub 2013 Apr 15. J Immunol. 2013. PMID: 23589618 Free PMC article.
Binding of Btn2a2-Fc to anti-CD3-stimulated T cells inhibited CD3epsilon, Zap70, and subsequent Erk1/2 activation. ...Using Foxp3-GFP-transgenic, naive T cells, Btn2a2-Fc induced de novo expression of Foxp3 in a dose-dependent manner, and Btn2a2-Fc-induced CD …
Binding of Btn2a2-Fc to anti-CD3-stimulated T cells inhibited CD3epsilon, Zap70, and subsequent Erk1/2 activation. ...Using Foxp3-GFP …
23 results