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Page 1
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.
Kwok AJ, Allcock A, Ferreira RC, Cano-Gamez E, Smee M, Burnham KL, Zurke YX; Emergency Medicine Research Oxford (EMROx); McKechnie S, Mentzer AJ, Monaco C, Udalova IA, Hinds CJ, Todd JA, Davenport EE, Knight JC. Kwok AJ, et al. Among authors: burnham kl. Nat Immunol. 2023 May;24(5):767-779. doi: 10.1038/s41590-023-01490-5. Epub 2023 Apr 24. Nat Immunol. 2023. PMID: 37095375
Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.
Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium. Scicluna BP, et al. Among authors: burnham kl. Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29. Lancet Respir Med. 2017. PMID: 28864056
An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.
Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D; GAinS Investigators; McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE, Knight JC, Webster N, Galley H, Taylor J, Hall S, Addison J, Roughton S, Tennant H, Guleri A, Waddington N, Arawwawala D, Durcan J, Short A, Swan K, Williams S, Smolen S, Mitchell-Inwang C, Gordon T, Errington E, Templeton M, Venatesh P, Ward G, McCauley M, Baudouin S, Higham C, Soar J, Grier S, Hall E, Brett S, Kitson D, Wilson R, Mountford L, Moreno J, Hall P, Hewlett J, McKechnie S, Garrard C, Millo J, Young D, Hutton P, Parsons P, Smiths A, Faras-Arraya R, Soar J, Raymode P, Thompson J, Bowrey S, Kazembe S, Rich N, Andreou P, Hales D, Roberts E, Fletcher S, Rosbergen M, Glister G, Cuesta JM, Bion J, Millar J, Perry EJ, Willis H, Mitchell N, Ruel S, Carrera R, Wilde J, Nilson A, Lees S, Kapila A, Jacques N, Atkinson J, Brown A, Prowse H, Krige A, Bland M, Bullock L, Harrison D, Mills G, Humphreys J, Armitage K, Laha S, Baldwin J, Walsh A, Doherty N, Drage S, Ortiz-Ruiz de Gordoa L, Lowes S, Higham C, Walsh H, Calder V, Swan C, Payne H, Higgins D, Andrews S, Mapp… See abstract for full author list ➔ Cano-Gamez E, et al. Among authors: burnham kl. Sci Transl Med. 2022 Nov 2;14(669):eabq4433. doi: 10.1126/scitranslmed.abq4433. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322631 Free PMC article.
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response.
Mi Y, Burnham KL, Charles PD, Heilig R, Vendrell I, Whalley J, Torrance HD, Antcliffe DB, May SM, Neville MJ, Berridge G, Hutton P, Geoghegan CG, Radhakrishnan J, Nesvizhskii AI, Yu F; GAinS Investigators; Davenport EE, McKechnie S, Davies R, O'Callaghan DJP, Patel P, Del Arroyo AG, Karpe F, Gordon AC, Ackland GL, Hinds CJ, Fischer R, Knight JC. Mi Y, et al. Among authors: burnham kl. Sci Transl Med. 2024 Jun 5;16(750):eadh0185. doi: 10.1126/scitranslmed.adh0185. Epub 2024 Jun 5. Sci Transl Med. 2024. PMID: 38838133
Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes.
Antcliffe DB, Mi Y, Santhakumaran S, Burnham KL, Prevost AT, Ward JK, Marshall TJ, Bradley C, Al-Beidh F, Hutton P, McKechnie S, Davenport EE, Hinds CJ, O'Kane CM, McAuley DF, Shankar-Hari M, Gordon AC, Knight JC. Antcliffe DB, et al. Among authors: burnham kl. Thorax. 2024 May 20;79(6):515-523. doi: 10.1136/thorax-2023-220538. Thorax. 2024. PMID: 38471792 Free PMC article.
COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas.
Wang D, Kumar V, Burnham KL, Mentzer AJ, Marsden BD, Knight JC. Wang D, et al. Among authors: burnham kl. Nucleic Acids Res. 2023 Jan 6;51(D1):D896-D905. doi: 10.1093/nar/gkac1019. Nucleic Acids Res. 2023. PMID: 36353986 Free PMC article.
Blood leukocyte transcriptomes in Gram-positive and Gram-negative community-acquired pneumonia.
Pereverzeva L, Uhel F, Peters Sengers H, Butler J, van Vught LA, Burnham KL, Davenport EE, Knight JC, Cremer OL, Schultz MJ, Bonten MMJ, Scicluna BP, van der Poll T; MARS consortium. Pereverzeva L, et al. Among authors: burnham kl. Eur Respir J. 2022 Mar 17;59(3):2101856. doi: 10.1183/13993003.01856-2021. Print 2022 Mar. Eur Respir J. 2022. PMID: 34446464 Free article.
21 results