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Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms.
Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Ren R, et al. Among authors: kopczynski c. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6197-6209. doi: 10.1167/iovs.16-20189. Invest Ophthalmol Vis Sci. 2016. PMID: 27842161 Free PMC article.
We investigated the effects of its active metabolite, netarsudil-M1, on outflow facility (C), outflow hydrodynamics, and morphology of the conventional outflow pathway in enucleated human eyes. ...CONCLUSIONS: Netarsudil acutely increased C by expansion of the JCT a …
We investigated the effects of its active metabolite, netarsudil-M1, on outflow facility (C), outflow hydrodynamics, and morphology o …
Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes.
Wang RF, Williamson JE, Kopczynski C, Serle JB. Wang RF, et al. Among authors: kopczynski c. J Glaucoma. 2015 Jan;24(1):51-4. doi: 10.1097/IJG.0b013e3182952213. J Glaucoma. 2015. PMID: 25535688
METHODS: Seven normotensive monkeys were used. Tonographic outflow facility (C) was measured before drug administration and repeated 6 hours after administration of 50 L (25 L2) of 0.04% AR-13324 to 1 eye and an equal volume of vehicle to the contralateral control eye. ... …
METHODS: Seven normotensive monkeys were used. Tonographic outflow facility (C) was measured before drug administration and repeated …