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Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children.
Beckmann ND, Comella PH, Cheng E, Lepow L, Beckmann AG, Mouskas K, Simons NW, Hoffman GE, Francoeur NJ, Del Valle DM, Kang G, Moya E, Wilkins L, Le Berichel J, Chang C, Marvin R, Calorossi S, Lansky A, Walker L, Yi N, Yu A, Hartnett M, Eaton M, Hatem S, Jamal H, Akyatan A, Tabachnikova A, Liharska LE, Cotter L, Fennessey B, Vaid A, Barturen G, Tyler SR, Shah H, Wang YC, Sridhar SH, Soto J, Bose S, Madrid K, Ellis E, Merzier E, Vlachos K, Fishman N, Tin M, Smith M, Xie H, Patel M, Argueta K, Harris J, Karekar N, Batchelor C, Lacunza J, Yishak M, Tuballes K, Scott L, Kumar A, Jaladanki S, Thompson R, Clark E, Losic B; Mount Sinai COVID-19 Biobank Team; Zhu J, Wang W, Kasarskis A, Glicksberg BS, Nadkarni G, Bogunovic D, Elaiho C, Gangadharan S, Ofori-Amanfo G, Alesso-Carra K, Onel K, Wilson KM, Argmann C, Alarcón-Riquelme ME, Marron TU, Rahman A, Kim-Schulze S, Gnjatic S, Gelb BD, Merad M, Sebra R, Schadt EE, Charney AW. Beckmann ND, et al. medRxiv [Preprint]. 2020 Sep 2:2020.08.29.20182899. doi: 10.1101/2020.08.29.20182899. medRxiv. 2020. Update in: Nat Commun. 2021 Aug 11;12(1):4854. doi: 10.1038/s41467-021-24981-1. PMID: 32909006 Free PMC article. Updated. Preprint.
To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric cases of coronavirus disease 2019, and healthy controls. ...Together, these findings suggest dysregulated cytotoxic lymphocyte response to SARS- …
To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric case …
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Beckmann ND, Comella PH, Cheng E, Lepow L, Beckmann AG, Tyler SR, Mouskas K, Simons NW, Hoffman GE, Francoeur NJ, Del Valle DM, Kang G, Do A, Moya E, Wilkins L, Le Berichel J, Chang C, Marvin R, Calorossi S, Lansky A, Walker L, Yi N, Yu A, Chung J, Hartnett M, Eaton M, Hatem S, Jamal H, Akyatan A, Tabachnikova A, Liharska LE, Cotter L, Fennessy B, Vaid A, Barturen G, Shah H, Wang YC, Sridhar SH, Soto J, Bose S, Madrid K, Ellis E, Merzier E, Vlachos K, Fishman N, Tin M, Smith M, Xie H, Patel M, Nie K, Argueta K, Harris J, Karekar N, Batchelor C, Lacunza J, Yishak M, Tuballes K, Scott I, Kumar A, Jaladanki S, Agashe C, Thompson R, Clark E, Losic B, Peters L; Mount Sinai COVID-19 Biobank Team; Roussos P, Zhu J, Wang W, Kasarskis A, Glicksberg BS, Nadkarni G, Bogunovic D, Elaiho C, Gangadharan S, Ofori-Amanfo G, Alesso-Carra K, Onel K, Wilson KM, Argmann C, Bunyavanich S, Alarcón-Riquelme ME, Marron TU, Rahman A, Kim-Schulze S, Gnjatic S, Gelb BD, Merad M, Sebra R, Schadt EE, Charney AW. Beckmann ND, et al. Nat Commun. 2021 Aug 11;12(1):4854. doi: 10.1038/s41467-021-24981-1. Nat Commun. 2021. PMID: 34381049 Free PMC article.
Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56(dim)CD57(+) natural killer (NK) cells and exhausted CD8(+) T cells. ...Together, this unbiased, transcriptom …
Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expr …
A Clinical Study of a Standardized Extract of Leaves of Dalbergia sissoo (Roxb ex DC) in Postmenopausal Osteoporosis.
Meeta, Raut AA, Agashe SV, Wajahat A, Sarada CV, Vaidya ADB, Vaidya RA. Meeta, et al. J Midlife Health. 2019 Jan-Mar;10(1):37-42. doi: 10.4103/jmh.JMH_22_19. J Midlife Health. 2019. PMID: 31001055 Free PMC article.
CONTEXT: Dalbergia sissoo had shown anti-osteoporotic and fracture-healing activities in animal models of postmenopausal osteoporosis (PMO). Standardized extract of leaves of D. sissoo (SEL-Ds) was clinically evaluated for osteoporosis. AIMS: To investigate the anti-osteop …
CONTEXT: Dalbergia sissoo had shown anti-osteoporotic and fracture-healing activities in animal models of postmenopausal osteoporosis (PMO). …
Paravertebral ligament ossification in vitamin D-resistant rickets: incidence, clinical significance, and genetic evaluation.
Lee SH, Agashe MV, Suh SW, Yoon YC, Song SH, Yang JH, Lee H, Song HR. Lee SH, et al. Spine (Phila Pa 1976). 2012 Jun 1;37(13):E792-6. doi: 10.1097/BRS.0b013e31824a3dc8. Spine (Phila Pa 1976). 2012. PMID: 22261628
OBJECTIVE: The objective of this study was to analyze the cases of paravertebral ossification in vitamin D-resistant rickets (VDRR) and elucidate its incidence and clinical significance, and report specific genetic mutations uniquely associated with this phenomenon. ...The …
OBJECTIVE: The objective of this study was to analyze the cases of paravertebral ossification in vitamin D-resistant rickets (VDRR) a …
Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression.
Kingery WS, Agashe GS, Sawamura S, Davies MF, Clark JD, Maze M. Kingery WS, et al. Anesth Analg. 2001 Feb;92(2):476-82. doi: 10.1097/00000539-200102000-00037. Anesth Analg. 2001. PMID: 11159254
Continuous infusion of methylprednisolone (3 mg. kg(-1). d(-1) for 21 days), started after the development of neuropathic hyperalgesia, reversed both heat and mechanical hyperalgesia over 2 wk, and this effect persisted for at least 1 wk after discontinuing methylprednisol …
Continuous infusion of methylprednisolone (3 mg. kg(-1). d(-1) for 21 days), started after the development of neuropathic hyperalgesi …
Hematocrit and whole blood viscosity in newborns: analysis of 100 cases.
Merchant RH, Phadke SD, Sakhalkar VS, Agashe VS, Puniyani RR. Merchant RH, et al. Indian Pediatr. 1992 May;29(5):555-61. Indian Pediatr. 1992. PMID: 1500102
Group A (n = 25), were term normal newborns, Group B (n = 25) were preterms, Group C (n = 20) were term small for gestation (SGA) and Group D (n = 30) had perinatal hypoxia. ...The mean hematocrit (Hct) (59.4%) and viscosity (8.2 cps) was higher in Group A as compar …
Group A (n = 25), were term normal newborns, Group B (n = 25) were preterms, Group C (n = 20) were term small for gestation (SGA) and …