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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1984 2
1991 3
1992 1
1993 1
1994 1
1995 4
1996 1
1997 1
1998 1
1999 1
2000 3
2001 6
2002 4
2003 4
2004 12
2005 7
2006 11
2007 10
2008 13
2009 11
2010 16
2011 19
2012 22
2013 31
2014 55
2015 70
2016 49
2017 57
2018 66
2019 68
2020 84
2021 96
2022 135
2023 122
2024 95

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1,002 results

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Page 1
Enantioselective Cobaltaphotoredox-Catalyzed C-H Activation.
Xu Y, Lin Y, Homölle SL, Oliveira JCA, Ackermann L. Xu Y, et al. J Am Chem Soc. 2024 Aug 28;146(34):24105-24113. doi: 10.1021/jacs.4c08459. Epub 2024 Aug 15. J Am Chem Soc. 2024. PMID: 39143928 Free PMC article.
Despite the impressive advances, enantioselective photoinduced strong arene C-H activations by cobalt catalysis remain unexplored. Herein, we report a strategy that merges organic photoredox catalysis and enantioselective cobalt-catalyzed C-H activatio …
Despite the impressive advances, enantioselective photoinduced strong arene C-H activations by cobalt catalysis remain unexplo …
Photo-Induced C-H Methylation Reactions.
Li QY, He Y, Lin YM, Gong L. Li QY, et al. Chemistry. 2023 Dec 22;29(72):e202302542. doi: 10.1002/chem.202302542. Epub 2023 Nov 10. Chemistry. 2023. PMID: 37800464 Review.
Direct C-H methylation is a highly valuable approach for introducing methyl groups into organic molecules, particularly in pharmaceutical chemistry. ...Importantly, a wide range of easily accessible agents such as tert-butyl peroxide, methanol, DMSO, methyl tert-but …
Direct C-H methylation is a highly valuable approach for introducing methyl groups into organic molecules, particularly in pha …
Sclerotiamides C-H, Notoamides from a Marine Gorgonian-Derived Fungus with Cytotoxic Activities.
Guo X, Meng Q, Liu J, Wu J, Jia H, Liu D, Gu Y, Liu J, Huang J, Fan A, Lin W. Guo X, et al. J Nat Prod. 2022 Apr 22;85(4):1067-1078. doi: 10.1021/acs.jnatprod.1c01194. Epub 2022 Feb 25. J Nat Prod. 2022. PMID: 35213164 Review.
Bioassay-guided fractionation in association with LC-MS and NMR detection led to the isolation of six new alkaloids, sclerotiamides C-H (1-6), from the marine gorgonian-derived fungus Aspergillus sclerotiorum LZDX-33-4. ...
Bioassay-guided fractionation in association with LC-MS and NMR detection led to the isolation of six new alkaloids, sclerotiamides C …
Electrochemical activation of C-H by electron-deficient W(2)C nanocrystals for simultaneous alkoxylation and hydrogen evolution.
Lin X, Zhang SN, Xu D, Zhang JJ, Lin YX, Zhai GY, Su H, Xue ZH, Liu X, Antonietti M, Chen JS, Li XH. Lin X, et al. Nat Commun. 2021 Jun 23;12(1):3882. doi: 10.1038/s41467-021-24203-8. Nat Commun. 2021. PMID: 34162882 Free PMC article.
The activation of C-H bonds is a central challenge in organic chemistry and usually a key step for the retro-synthesis of functional natural products due to the high chemical stability of C-H bonds. Electrochemical methods are a powerful alternative fo …
The activation of C-H bonds is a central challenge in organic chemistry and usually a key step for the retro-synthesis of func …
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C(H)1-C(lambda) interface.
Bagert JD, Oganesyan V, Chiang CI, Iannotti M, Lin J, Yang C, Payne S, McMahon W, Edwards S, Dippel A, Hutchinson M, Huang F, Aleti V, Niu C, Qian C, Denham J, Ferreira S, Pradhan P, Penney M, Wang C, Liu W, Walseng E, Mazor Y. Bagert JD, et al. MAbs. 2023 Jan-Dec;15(1):2273449. doi: 10.1080/19420862.2023.2273449. Epub 2023 Nov 6. MAbs. 2023. PMID: 37930310 Free PMC article.
Previously, we introduced the DuetMab platform as a general solution for the production of bsIgGs, which utilizes an engineered interchain disulfide bond in one of the C(H)1-C(L) domains to promote orthogonal chain pairing between heavy and light chains. ...Here, we …
Previously, we introduced the DuetMab platform as a general solution for the production of bsIgGs, which utilizes an engineered interchain d …
Cu(II)-Mediated C(sp(2))-H Hydroxylation.
Sun SZ, Shang M, Wang HL, Lin HX, Dai HX, Yu JQ. Sun SZ, et al. J Org Chem. 2015 Sep 4;80(17):8843-8. doi: 10.1021/acs.joc.5b01351. Epub 2015 Aug 17. J Org Chem. 2015. PMID: 26259687
A Cu(II)-mediated ortho-C-H hydroxylation using a removable directing group has been developed. The reaction exhibits considerable functional group tolerance. ...
A Cu(II)-mediated ortho-C-H hydroxylation using a removable directing group has been developed. The reaction exhibits consider …
AgNTf(2)-Catalyzed Regioselective C-H Alkenylation of N,N-Dialkylanilines with Ynamides.
Nie XD, Mao ZY, Guo JM, Si CM, Wei BG, Lin GQ. Nie XD, et al. J Org Chem. 2022 Mar 4;87(5):2380-2392. doi: 10.1021/acs.joc.1c02263. Epub 2022 Jan 18. J Org Chem. 2022. PMID: 35041783
Regioselective C-H alkenylation of N,N-dialkylanilines with ynamides was developed using AgNTf(2) as a catalyst. ...
Regioselective C-H alkenylation of N,N-dialkylanilines with ynamides was developed using AgNTf(2) as a catalyst. ...
Regioselective aliphatic C-H functionalization using frustrated radical pairs.
Lu Z, Ju M, Wang Y, Meinhardt JM, Martinez Alvarado JI, Villemure E, Terrett JA, Lin S. Lu Z, et al. Nature. 2023 Jul;619(7970):514-520. doi: 10.1038/s41586-023-06131-3. Epub 2023 Jul 5. Nature. 2023. PMID: 37407819 Free PMC article.
Together, these species undergo single-electron transfer to generate a transient and persistent radical pair capable of cleaving unactivated C-H bonds to furnish aminoxylated products. By tuning the structure of the donor, it is possible to control regioselectivity …
Together, these species undergo single-electron transfer to generate a transient and persistent radical pair capable of cleaving unactivated …
1,002 results