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Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease.
Bakker WM, Heerspink HJL, Berger SP, Wanner C, Badve SV, Arnott C, Abrahams AC, van den Born JC, van Faassen TC, Gaillard CAJM, Gelens MACJ, Górris JL, Hemmelder MH, Jakulj L, van Kruijsdijk RCM, Kuypers DRJ, van der Meer P, van der Net JB, Nijmeijer HH, Vervloet MG, de Vries APJ, Walsh M, Wang AY, Gansevoort RT; Renal Lifecycle Trial Investigators. Bakker WM, et al. Nephrol Dial Transplant. 2025 Aug 29;40(9):1746-1755. doi: 10.1093/ndt/gfaf046. Nephrol Dial Transplant. 2025. PMID: 40053493 Free PMC article.
Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.
Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL, Les AS, Collins P, Gregg KM, Di J, Lu Y, Tudor IC, Wyman BT, Booth K, Broome S, Yuen E, Grundman M, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Liu E, et al. Neurology. 2015 Aug 25;85(8):692-700. doi: 10.1212/WNL.0000000000001877. Epub 2015 Jul 24. Neurology. 2015. PMID: 26208959 Free PMC article. Clinical Trial.
Cardiac impact of dapagliflozin in advanced chronic kidney disease: rationale and design of the Renal Lifecycle Trial cardiac imaging sub-studies.
Karsten M, Badve SV, Gansevoort RT, Berger SP, Heerspink HJL, Abrahams AC, Billot L, Bon RHACM, Gelens MACJ, Guinness D, Hamilton-Craig C, van Heerebeek L, Hemmelder MH, Houston L, Kozor R, Kuypers DRJ, Monaghan H, Neal B, Neuen BL, Otton J, Perkovic V, Rajwani A, Wang AY, Vervloet MG, Arnott C, Jakulj L; Renal Lifecycle Trial Cardiac Imaging Sub-studies Investigators. Karsten M, et al. Clin Kidney J. 2025 Dec 2;19(1):sfaf376. doi: 10.1093/ckj/sfaf376. eCollection 2026 Jan. Clin Kidney J. 2025. PMID: 41551843 Free PMC article.
Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling.
Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor SS, Veglia G. Srivastava AK, et al. Structure. 2014 Dec 2;22(12):1735-1743. doi: 10.1016/j.str.2014.09.010. Epub 2014 Nov 6. Structure. 2014. PMID: 25458836 Free PMC article.
Here, we used NMR spectroscopy to analyze the conformational fluctuations of the catalytic subunit of the cAMP-dependent protein kinase (PKA-C), a ubiquitous enzyme involved in a myriad of cell signaling events. We found that the wild-type enzyme undergoes synchrono …
Here, we used NMR spectroscopy to analyze the conformational fluctuations of the catalytic subunit of the cAMP-dependent protein kinase (PKA …
Some genetic aspects of the symbiotic relationship between white clover (Trifolium repens) and Rhizobium Trifolii.
Connolly V, Masterson CL, Conniffe D. Connolly V, et al. Theor Appl Genet. 1969 Jan;39(5):206-13. doi: 10.1007/BF00281975. Theor Appl Genet. 1969. PMID: 24435482
Reciprocal (both general and specific) as well as additive (g.c.a.) and non-additive (s.c.a.) effects were present. Experiment 3, in which seed from 22 families of the diallel cross was sown in soil without controlled inoculation, indicated that the re …
Reciprocal (both general and specific) as well as additive (g.c.a.) and non-additive (s.c.a.) effects were prese …