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Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells.
Hicks DF, Goossens N, Blas-García A, Tsuchida T, Wooden B, Wallace MC, Nieto N, Lade A, Redhead B, Cederbaum AI, Dudley JT, Fuchs BC, Lee YA, Hoshida Y, Friedman SL. Hicks DF, et al. Sci Rep. 2017 Mar 3;7:42563. doi: 10.1038/srep42563. Sci Rep. 2017. PMID: 28256512 Free PMC article.
To identify proteins mediating apigenin's effect, we next overlapped a 122-gene signature unique to HSCs with a list of 160 genes encoding proteins that are known to interact with apigenin, which identified C1QTNF2, encoding for Complement C1q tumor necrosis factor-related …
To identify proteins mediating apigenin's effect, we next overlapped a 122-gene signature unique to HSCs with a list of 160 genes encoding p …
Red Algae Alters Expression of Inflammatory Pathways in an Osteoarthritis In Vitro Co-Culture.
Heffernan SM, Waldron M, Meldrum K, Evans SJ, Conway GE. Heffernan SM, et al. Pharmaceuticals (Basel). 2025 Feb 24;18(3):315. doi: 10.3390/ph18030315. Pharmaceuticals (Basel). 2025. PMID: 40143094 Free PMC article.
Following treatment, Litho reduced the expression of inflammatory and pain associated genes, most notably IL-1beta, IL-6, PTGS2 (COX-2) and C1qTNF2 (CTRP2). Confirmatory analysis with droplet digital PCR (ddPCR) revealed that Il-1beta induced a significant reduction in …
Following treatment, Litho reduced the expression of inflammatory and pain associated genes, most notably IL-1beta, IL-6, PTGS2 (COX-2) and …
Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis.
S SH, G K, Dey H, Sangoji RV, Thirumal Kumar D, Zayed H, Vasudevan K, George Priya Doss C. S SH, et al. Adv Protein Chem Struct Biol. 2023;137:181-203. doi: 10.1016/bs.apcsb.2023.02.011. Epub 2023 Mar 14. Adv Protein Chem Struct Biol. 2023. PMID: 37709376
As a part of our study, we also identified various related circadian genes, such as CXCL12, C1QTNF2, MRC2, and GLUL, from the Circadian Gene Expression database, that played a role in circadian rhythm and CRC development. ...
As a part of our study, we also identified various related circadian genes, such as CXCL12, C1QTNF2, MRC2, and GLUL, from the Circadi …
Identification of Important Diagnostic Genes in the Uterine Using Bioinformatics and Machine Learning.
Valizadeh Laktarashi H, Rahimi M, Abrishamifar K, Mahmoudabadi A, Nazari E. Valizadeh Laktarashi H, et al. Med J Islam Repub Iran. 2025 Jan 6;39:4. doi: 10.47176/mjiri.39.4. eCollection 2025. Med J Islam Repub Iran. 2025. PMID: 40486012 Free PMC article.
RESULTS: According to our findings, MEX3B, CTRP2 (C1QTNF2), and AASS are new biomarkers for UCEC. The evaluation metrics demonstrate the deep learning model's (DNN) efficacy, with a minimal mean squared error (MSE) of 5.1096067E-5 and a root mean squared error (RMSE) of 0. …
RESULTS: According to our findings, MEX3B, CTRP2 (C1QTNF2), and AASS are new biomarkers for UCEC. The evaluation metrics demonstrate …
Analysis of Staged Features of Gastritis-Cancer Transformation and Identification of Potential Biomarkers in Gastric Cancer.
Jia R, Guo X, Liu H, Zhao F, Fan Z, Wang M, Sui J, Yin B, Wang Z, Wang Z. Jia R, et al. J Inflamm Res. 2022 Dec 28;15:6857-6868. doi: 10.2147/JIR.S390448. eCollection 2022. J Inflamm Res. 2022. PMID: 36597437 Free PMC article.
Thirty-four potential biomarkers for gastric cancer were identified, of which 14 genes have not been reported, including ACTG2, C1QTNF2, NCAPH and SORCS1. CONCLUSION: There may be a stable development mechanism in the process of gastritis-carcinoma transformation, resultin …
Thirty-four potential biomarkers for gastric cancer were identified, of which 14 genes have not been reported, including ACTG2, C1QTNF2
Genetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA.
Fan S, Yuan P, Li S, Li H, Zhai B, Li Y, Zhang H, Gu J, Li H, Tian Y, Kang X, Zhang Y, Li G. Fan S, et al. BMC Genomics. 2023 Aug 3;24(1):434. doi: 10.1186/s12864-023-09503-1. BMC Genomics. 2023. PMID: 37537524 Free PMC article.
Combining two strategies, 9 hub genes (ENO1, ADH1, ASAH1, ADH1C, PIK3CD, WISP1, AKT1, PANK3, and C1QTNF2) were finally identified, which could be the potential candidate genes regulating fatty acid composition traits in chicken breast muscle. ...
Combining two strategies, 9 hub genes (ENO1, ADH1, ASAH1, ADH1C, PIK3CD, WISP1, AKT1, PANK3, and C1QTNF2) were finally identified, wh …
CTRP family: linking immunity to metabolism.
Schäffler A, Buechler C. Schäffler A, et al. Trends Endocrinol Metab. 2012 Apr;23(4):194-204. doi: 10.1016/j.tem.2011.12.003. Epub 2012 Jan 17. Trends Endocrinol Metab. 2012. PMID: 22261190 Review.
Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer.
Banaganapalli B, Mallah B, Alghamdi KS, Albaqami WF, Alshaer DS, Alrayes N, Elango R, Shaik NA. Banaganapalli B, et al. PLoS One. 2022 Oct 4;17(10):e0274629. doi: 10.1371/journal.pone.0274629. eCollection 2022. PLoS One. 2022. PMID: 36194576 Free PMC article.
Of these DEGs, 12 COPD hub gene-network clusters (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, and DDX3Y) connected to dysregulations of protein degradation, inflammatory cytokine production, airway remodeling, and immune cell activity we …
Of these DEGs, 12 COPD hub gene-network clusters (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, and …
12 results