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78 results

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Page 1
C8B in Complement and Coagulation Cascades Signaling Pathway is a predictor for Survival in HBV-Related Hepatocellular Carcinoma Patients.
Zhang Y, Chen X, Cao Y, Yang Z. Zhang Y, et al. Cancer Manag Res. 2021 Apr 22;13:3503-3515. doi: 10.2147/CMAR.S302917. eCollection 2021. Cancer Manag Res. 2021. PMID: 33911900 Free PMC article.

The complement and coagulation cascades pathway was significantly enriched by 37 DEGs (p-value < 0.05 and adjusted p-value < 0.05). Complement 8 beta chain (C8B) expression levels had protective effects on overall survival (OS) and recurrence-free survival (RFS) in H

…

The complement and coagulation cascades pathway was significantly enriched by 37 DEGs (p-value < 0.05 and adjusted p-value < 0.05). Co

…
Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?
Mannes M, Halbgebauer R, Wohlgemuth L, Messerer DAC, Savukoski S, Schultze A, Berger B, Knapp CL, Schmidt CQ, Fürst D, Hillmer M, Siebert R, Eriksson O, Persson B, Nilsson B, Nilsson Ekdahl K, Huber-Lang M. Mannes M, et al. J Innate Immun. 2023;15(1):412-427. doi: 10.1159/000528607. Epub 2023 Mar 1. J Innate Immun. 2023. PMID: 36858027 Free PMC article.
Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C&gt;T; p.(Thr542Ile)) are known individually, here, we report on a patient carrying their combination in a heterozygous form. ...This study describes for the first time …
Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C&gt;T; p.(Thr542Ile)) are kno …
[Recurrent meningococcal infection in a young woman witha mutation in the C8B gene].
Andersen UØ, Bay JT, Jensen LH. Andersen UØ, et al. Ugeskr Laeger. 2022 Jun 6;184(23):V02220113. Ugeskr Laeger. 2022. PMID: 35703060 Free article. Danish.
Further genetical analysis revealed a pathogen mutation in the C8B gene in the patient and her sister. They were both immunised with meningococcal vaccines. ...
Further genetical analysis revealed a pathogen mutation in the C8B gene in the patient and her sister. They were both immunised with …
The human complement component C8B gene: structure and phylogenetic relationship.
Kaufmann T, Rittner C, Schneider PM. Kaufmann T, et al. Hum Genet. 1993 Aug;92(1):69-75. doi: 10.1007/BF00216147. Hum Genet. 1993. PMID: 8365729
These analyses and the insert sizes of the genomic lambda clones indicate that the C8B gene has a total size of approximately 40 kb. The polymorphic TaqI site of the C8B gene localized in intron 11 could be demonstrated by direct restriction fragment analysis of a P …
These analyses and the insert sizes of the genomic lambda clones indicate that the C8B gene has a total size of approximately 40 kb. …
A BamH1 RFLP of the C8B gene.
Rogde S, Mevåg B, Teisberg P, Olaisen B, Sodetz J. Rogde S, et al. Nucleic Acids Res. 1989 Aug 25;17(16):6760. doi: 10.1093/nar/17.16.6760. Nucleic Acids Res. 1989. PMID: 2571125 Free PMC article. No abstract available.
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia.
Lafta MS, Rukh G, Hamdeh SA, Molero Y, Sokolov AV, Rostami E, Schiöth HB. Lafta MS, et al. J Mol Neurosci. 2024 Oct 3;74(4):91. doi: 10.1007/s12031-024-02263-x. J Mol Neurosci. 2024. PMID: 39361088 Free PMC article.
The study sample comprised of diagnosed TN cases (N = 555) and randomly matched controls (N = 6245) based on specific criteria. Two SNPs corresponding to C8B rs706484 [odds ratio (OR) (95% confidence interval (CI)): 1.357 (1.158-1.590); p: 0.00016] and MFG-E8 rs2015495 [OR …
The study sample comprised of diagnosed TN cases (N = 555) and randomly matched controls (N = 6245) based on specific criteria. Two SNPs cor …
Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus.
Kershaw EE, Chua SC, Williams JA, Murphy EM, Leibel RL. Kershaw EE, et al. Genomics. 1995 May 1;27(1):149-54. doi: 10.1006/geno.1995.1017. Genomics. 1995. PMID: 7665162
We report the identification of two (GT)n simple sequence repeats (SSRs) near the rat phosphoglucomutase gene (Pgm1) gene and two SSRs, (GA)n and (GT)n, near the rat complement component 8 beta gene (C8b). These SSRs map to an approximately 4-cM interval flanking the fatty …
We report the identification of two (GT)n simple sequence repeats (SSRs) near the rat phosphoglucomutase gene (Pgm1) gene and two SSRs, (GA) …
Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
Liu Y, Tang Y, Jiang H, Zhang X, Chen X, Guo J, Jin C, Wu M. Liu Y, et al. Biomolecules. 2023 Dec 28;14(1):41. doi: 10.3390/biom14010041. Biomolecules. 2023. PMID: 38254641 Free PMC article.
RESULTS: A total of 83 DEGs enriched in the extracellular exosome term, among which, FTCD, HRA, and C8B showed the strongest association with the progression of HCC. FTCD was independently associated with a protective effect in HCC and selected as the hub gene. ...
RESULTS: A total of 83 DEGs enriched in the extracellular exosome term, among which, FTCD, HRA, and C8B showed the strongest associat …
Biodegradation of endosulfan and endosulfan sulfate by Achromobacter xylosoxidans strain C8B in broth medium.
Singh NS, Singh DK. Singh NS, et al. Biodegradation. 2011 Sep;22(5):845-57. doi: 10.1007/s10532-010-9442-0. Epub 2010 Dec 15. Biodegradation. 2011. PMID: 21161332
Out of the 8 isolated bacterial strains, strain C8B was found to be the most efficient endosulfan degrader, degrading 94.12% alpha-endosulfan and 84.52% beta-endosulfan. The bacterial strain was identified as Achromobacter xylosoxidans strain C8B on the basis of 16S …
Out of the 8 isolated bacterial strains, strain C8B was found to be the most efficient endosulfan degrader, degrading 94.12% alpha-en …
Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies.
Hatchwell E, Smith EB 3rd, Jalilzadeh S, Bruno CD, Taoufik Y, Hendel-Chavez H, Liblau R, Brassat D, Martin-Blondel G, Wiendl H, Schwab N, Cortese I, Monaco MC, Imberti L, Capra R, Oksenberg JR, Gasnault J, Stankoff B, Richmond TA, Rancour DM, Koralnik IJ, Hanson BA, Major EO, Chow CR, Eis PS. Hatchwell E, et al. Front Neurol. 2022 Dec 14;13:1016377. doi: 10.3389/fneur.2022.1016377. eCollection 2022. Front Neurol. 2022. PMID: 36588876 Free PMC article.
RESULTS: The four variants, found in immune system genes with strong biological links, are: C8B, 1-57409459-C-A, rs139498867; LY9 (alias SLAMF3), 1-160769595-AG-A, rs763811636; FCN2, 9-137779251-G-A, rs76267164; STXBP2, 19-7712287-G-C, rs35490401. ...
RESULTS: The four variants, found in immune system genes with strong biological links, are: C8B, 1-57409459-C-A, rs139498867; LY9 (al …
78 results