Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 2
2012 1
2013 2
2014 6
2015 5
2016 5
2017 4
2018 6
2019 9
2020 17
2021 27
2022 33
2023 43
2024 107
2025 117
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

352 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for challenge s[au]
Your search for CHALLENER S[au] retrieved no results
Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer.
Deepak KGK, Vempati R, Nagaraju GP, Dasari VR, S N, Rao DN, Malla RR. Deepak KGK, et al. Among authors: s n. Pharmacol Res. 2020 Mar;153:104683. doi: 10.1016/j.phrs.2020.104683. Epub 2020 Feb 9. Pharmacol Res. 2020. PMID: 32050092 Review.
Finally, we also discussed various phytochemicals that alter genetic, transcriptomic and proteomic profiles of TME along with current challenges and future implications. Thus, as TME is associated with the hallmarks of TNBC, the understanding of the impact of different com …
Finally, we also discussed various phytochemicals that alter genetic, transcriptomic and proteomic profiles of TME along with current cha
Oral Pemphigus Vulgaris.
Subadra K, S S, Warrier S A. Subadra K, et al. Among authors: s s. Cureus. 2021 Sep 15;13(9):e18005. doi: 10.7759/cureus.18005. eCollection 2021 Sep. Cureus. 2021. PMID: 34671517 Free PMC article.
Management of PV involves prolonged use of steroids to control the disease and prevent relapses, but associated adverse events constantly remain a great challenge. Regular periodic clinical evaluation of patients with pemphigus on steroids is mandatory. ...
Management of PV involves prolonged use of steroids to control the disease and prevent relapses, but associated adverse events constantly re …
Lignocellulosic biomass-based pyrolysis: A comprehensive review.
K N Y, T PD, P S, S K, R YK, Varjani S, AdishKumar S, Kumar G, J RB. K N Y, et al. Among authors: s k. Chemosphere. 2022 Jan;286(Pt 2):131824. doi: 10.1016/j.chemosphere.2021.131824. Epub 2021 Aug 6. Chemosphere. 2022. PMID: 34388872 Review.
This article also illustrates the prevailing challenges and inhibition in implementing lignocellulosic biomass based pyrolysis with possible solution....
This article also illustrates the prevailing challenges and inhibition in implementing lignocellulosic biomass based pyrolysis with p …
Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights.
Altalbawy FMA, Mukhlif BAM, Hussen A, Mohammed JS, S RJ, Singh A, Mishra SB, Chauhan AS, Astaneh ME, Fereydouni N. Altalbawy FMA, et al. Among authors: s rj. Regen Ther. 2025 Jun 26;30:278-298. doi: 10.1016/j.reth.2025.06.008. eCollection 2025 Dec. Regen Ther. 2025. PMID: 40654520 Free PMC article. Review.
CONCLUSIONS: PRP-based scaffolds offer a multifunctional platform for chronic wound treatment by combining biological activity with structural support. Despite existing challenges such as variability in PRP preparation and limited clinical data, ongoing research and emergi …
CONCLUSIONS: PRP-based scaffolds offer a multifunctional platform for chronic wound treatment by combining biological activity with structur …
Silence of the mutations.
S M. S M. J Biosci. 2022;47:74. J Biosci. 2022. PMID: 36510436 Free article.
They propose that a larger proportion of synonymous mutants reach fixation compared with their non-synonymous counterparts because more of them survive environmental challenges. In this Clipboard article, I examine the evidence provided by the authors to evaluate whether t …
They propose that a larger proportion of synonymous mutants reach fixation compared with their non-synonymous counterparts because more of t …
Solid lipid nanoparticles for hydrophilic drugs.
Mirchandani Y, Patravale VB, S B. Mirchandani Y, et al. Among authors: s b. J Control Release. 2021 Jul 10;335:457-464. doi: 10.1016/j.jconrel.2021.05.032. Epub 2021 May 25. J Control Release. 2021. PMID: 34048841 Review.
Although SLNs have been widely studied as carriers for hydrophobic drugs, delivery of hydrophilic molecules remains a challenge. Hence, the current review focuses on different approaches that have been used for the delivery of hydrophilic drugs using SLNs. ...
Although SLNs have been widely studied as carriers for hydrophobic drugs, delivery of hydrophilic molecules remains a challenge. Henc …
Sweat analysis for urea sensing: trends and challenges.
Futane A, Senthil M, S J, Srinivasan A, R K, Narayanamurthy V. Futane A, et al. Among authors: s j. Anal Methods. 2023 Sep 14;15(35):4405-4426. doi: 10.1039/d3ay01089a. Anal Methods. 2023. PMID: 37646163 Review.
In the end, research and technological advancements are explained to address current challenges and enable its widespread implementation....
In the end, research and technological advancements are explained to address current challenges and enable its widespread implementat …
Upadacitinib in Crohn's Disease: A Comprehensive Systematic Review of Efficacy and Safety.
Wodeyar AM, Pansuriya N, Saeed S, Lakhani A, Sartaj S, Keerthi NSJ, Guntur Bhuvika Raji A, S B, Wahane V, Thapa Y, Abriha F. Wodeyar AM, et al. Among authors: s b. Cureus. 2023 Dec 17;15(12):e50657. doi: 10.7759/cureus.50657. eCollection 2023 Dec. Cureus. 2023. PMID: 38229787 Free PMC article. Review.
Crohn's disease (CD) presents a formidable challenge as a chronic inflammatory condition. This systematic review aimed to comprehensively assess upadacitinib, a novel Janus kinase (JAK) inhibitor, regarding its efficacy, safety, and mechanistic insights in CD treatment. .. …
Crohn's disease (CD) presents a formidable challenge as a chronic inflammatory condition. This systematic review aimed to comprehensi …
Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health.
Kumar V, S H, Huligowda LKD, Umesh M, Chakraborty P, Thazeem B, Singh AP. Kumar V, et al. Among authors: s h. Biomedicines. 2025 Jan 20;13(1):241. doi: 10.3390/biomedicines13010241. Biomedicines. 2025. PMID: 39857824 Free PMC article. Review.
This review explores the impact of cardiovascular disease, discussing risk-assessment methods, intervention strategies, and the challenges clinicians face in addressing pollutant-induced cardiovascular diseases. It calls for stronger regulatory policies, public health inte …
This review explores the impact of cardiovascular disease, discussing risk-assessment methods, intervention strategies, and the challenge
Marine bioactives: a new frontier in neurosurgical therapeutics.
C M MM, B BS, A S, S VA. C M MM, et al. Among authors: s va. Neurosurg Rev. 2024 Oct 12;47(1):790. doi: 10.1007/s10143-024-03034-3. Neurosurg Rev. 2024. PMID: 39394429 Review.
Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite therapeutic promise, major challenges remain: those of sustainable sourcing and regulatory validation. This letter points up the poten …
Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite t …
352 results