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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 2
1984 1
1985 2
1986 4
1988 2
1989 4
1991 2
1992 3
1993 2
1994 1
1995 2
1996 5
1997 4
1998 5
1999 5
2000 5
2001 3
2002 7
2003 4
2004 11
2005 10
2006 10
2007 5
2008 8
2009 6
2010 7
2011 6
2012 17
2013 13
2014 15
2015 15
2016 10
2017 15
2018 15
2019 23
2020 24
2021 9
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260 results
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Page 1
Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor.
Gillis A, Kliewer A, Kelly E, Henderson G, Christie MJ, Schulz S, Canals M. Gillis A, et al. Among authors: canals m. Trends Pharmacol Sci. 2020 Dec;41(12):947-959. doi: 10.1016/ Epub 2020 Oct 20. Trends Pharmacol Sci. 2020. PMID: 33097283 Free article. Review.
Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.
Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E, Sánchez C. Blasco-Benito S, et al. Among authors: canals m. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3863-3872. doi: 10.1073/pnas.1815034116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733293 Free PMC article.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Among authors: canals m. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M. Gillis A, et al. Among authors: canals m. Sci Signal. 2020 Mar 31;13(625):eaaz3140. doi: 10.1126/scisignal.aaz3140. Sci Signal. 2020. PMID: 32234959
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Jimenez-Vargas NN, Gong J, Wisdom MJ, Jensen DD, Latorre R, Hegron A, Teng S, DiCello JJ, Rajasekhar P, Veldhuis NA, Carbone SE, Yu Y, Lopez-Lopez C, Jaramillo-Polanco J, Canals M, Reed DE, Lomax AE, Schmidt BL, Leong KW, Vanner SJ, Halls ML, Bunnett NW, Poole DP. Jimenez-Vargas NN, et al. Among authors: canals m. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15281-15292. doi: 10.1073/pnas.2000500117. Epub 2020 Jun 16. Proc Natl Acad Sci U S A. 2020. PMID: 32546520 Free PMC article.
Opioid Pharmacology under the Microscope.
Jullié D, Gondin AB, von Zastrow M, Canals M. Jullié D, et al. Among authors: canals m. Mol Pharmacol. 2020 Oct;98(4):425-432. doi: 10.1124/mol.119.119321. Epub 2020 Mar 20. Mol Pharmacol. 2020. PMID: 32198210 Review.
The Life Cycle of the Mu-Opioid Receptor.
Cuitavi J, Hipólito L, Canals M. Cuitavi J, et al. Among authors: canals m. Trends Biochem Sci. 2021 Apr;46(4):315-328. doi: 10.1016/j.tibs.2020.10.002. Epub 2020 Oct 27. Trends Biochem Sci. 2021. PMID: 33127216 Review.
Editorial: Novel Molecular Targets for the Treatment of Pain.
Largent-Milnes TM, Canals M, Streicher JM. Largent-Milnes TM, et al. Among authors: canals m. Front Mol Neurosci. 2020 Dec 11;13:625714. doi: 10.3389/fnmol.2020.625714. eCollection 2020. Front Mol Neurosci. 2020. PMID: 33424551 Free PMC article. No abstract available.
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW. Jensen DD, et al. Among authors: canals m. Sci Transl Med. 2017 May 31;9(392):eaal3447. doi: 10.1126/scitranslmed.aal3447. Sci Transl Med. 2017. PMID: 28566424 Free PMC article.
GRKs as Key Modulators of Opioid Receptor Function.
Lemel L, Lane JR, Canals M. Lemel L, et al. Among authors: canals m. Cells. 2020 Nov 2;9(11):2400. doi: 10.3390/cells9112400. Cells. 2020. PMID: 33147802 Free PMC article. Review.
260 results
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