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Page 1
A Deep Learning Approach to Antibiotic Discovery.
Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackermann Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, Church GM, Brown ED, Jaakkola TS, Barzilay R, Collins JJ. Stokes JM, et al. Among authors: carfrae la. Cell. 2020 Feb 20;180(4):688-702.e13. doi: 10.1016/j.cell.2020.01.021. Cell. 2020. PMID: 32084340 Free PMC article.
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database.
Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, Edalatmand A, Petkau A, Syed SA, Tsang KK, Baker SJC, Dave M, McCarthy MC, Mukiri KM, Nasir JA, Golbon B, Imtiaz H, Jiang X, Kaur K, Kwong M, Liang ZC, Niu KC, Shan P, Yang JYJ, Gray KL, Hoad GR, Jia B, Bhando T, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM, Bordeleau E, Dooley D, Griffiths E, Zubyk HL, Brown ED, Maguire F, Beiko RG, Hsiao WWL, Brinkman FSL, Van Domselaar G, McArthur AG. Alcock BP, et al. Among authors: carfrae la. Nucleic Acids Res. 2023 Jan 6;51(D1):D690-D699. doi: 10.1093/nar/gkac920. Nucleic Acids Res. 2023. PMID: 36263822 Free PMC article.
A Deep Learning Approach to Antibiotic Discovery.
Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackermann Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, Church GM, Brown ED, Jaakkola TS, Barzilay R, Collins JJ. Stokes JM, et al. Among authors: carfrae la. Cell. 2020 Apr 16;181(2):475-483. doi: 10.1016/j.cell.2020.04.001. Cell. 2020. PMID: 32302574 Free article. No abstract available.
Inhibiting fatty acid synthesis overcomes colistin resistance.
Carfrae LA, Rachwalski K, French S, Gordzevich R, Seidel L, Tsai CN, Tu MM, MacNair CR, Ovchinnikova OG, Clarke BR, Whitfield C, Brown ED. Carfrae LA, et al. Nat Microbiol. 2023 Jun;8(6):1026-1038. doi: 10.1038/s41564-023-01369-z. Epub 2023 May 1. Nat Microbiol. 2023. PMID: 37127701
The aryl hydrocarbon receptor and FOS mediate cytotoxicity induced by Acinetobacter baumannii.
Kew C, Prieto-Garcia C, Bhattacharya A, Tietgen M, MacNair CR, Carfrae LA, Mello-Vieira J, Klatt S, Cheng YL, Rathore R, Gradhand E, Fleming I, Tan MW, Göttig S, Kempf VAJ, Dikic I. Kew C, et al. Among authors: carfrae la. Nat Commun. 2024 Sep 11;15(1):7939. doi: 10.1038/s41467-024-52118-7. Nat Commun. 2024. PMID: 39261458 Free PMC article.
Nutrient stress is a target for new antibiotics.
Carfrae LA, Brown ED. Carfrae LA, et al. Trends Microbiol. 2023 Jun;31(6):571-585. doi: 10.1016/j.tim.2023.01.002. Epub 2023 Jan 27. Trends Microbiol. 2023. PMID: 36709096 Review.
Uncovering the Hidden Antibiotic Potential of Cannabis.
Farha MA, El-Halfawy OM, Gale RT, MacNair CR, Carfrae LA, Zhang X, Jentsch NG, Magolan J, Brown ED. Farha MA, et al. Among authors: carfrae la. ACS Infect Dis. 2020 Mar 13;6(3):338-346. doi: 10.1021/acsinfecdis.9b00419. Epub 2020 Feb 6. ACS Infect Dis. 2020. PMID: 32017534
Overcoming Acquired and Native Macrolide Resistance with Bicarbonate.
Farha MA, MacNair CR, Carfrae LA, El Zahed SS, Ellis MJ, Tran HR, McArthur AG, Brown ED. Farha MA, et al. Among authors: carfrae la. ACS Infect Dis. 2020 Oct 9;6(10):2709-2718. doi: 10.1021/acsinfecdis.0c00340. Epub 2020 Sep 18. ACS Infect Dis. 2020. PMID: 32898415
13 results