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The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
Reddy KK, Lefkove B, Chen LB, Govindarajan B, Carracedo A, Velasco G, Carrillo CO, Bhandarkar SS, Owens MJ, Mechta-Grigoriou F, Arbiser JL. Reddy KK, et al. Among authors: carrillo co. Pigment Cell Melanoma Res. 2008 Aug;21(4):451-6. doi: 10.1111/j.1755-148X.2008.00481.x. Pigment Cell Melanoma Res. 2008. PMID: 18710373
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carrillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Williams J, Brown LF, Tan X, Ioffe E, Yancopoulos GD, Arbiser JL. Perry BN, et al. Among authors: carrillo co. J Invest Dermatol. 2006 Oct;126(10):2316-22. doi: 10.1038/sj.jid.5700413. Epub 2006 Jun 1. J Invest Dermatol. 2006. PMID: 16741507 Free article.