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Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity.
Huang Z, Whelan CV, Dechmann D, Teeling EC. Huang Z, et al. Aging (Albany NY). 2020 Sep 5;12(16):15962-15977. doi: 10.18632/aging.103725. Aging (Albany NY). 2020. PMID: 32674072 Free PMC article.
Genome-wide selection tests on 12,467 single-copy genes between M. myotis and M. molossus revealed only three genes (CCDC175, FATE1 and MLKL) that exhibited significant positive selection. Although 97.96% of 12,467 genes underwent purifying selection, we observed a signifi …
Genome-wide selection tests on 12,467 single-copy genes between M. myotis and M. molossus revealed only three genes (CCDC175, FATE1 a …
The impact of modifier genes on cone-rod dystrophy heterogeneity: An explorative familial pilot study and a hypothesis on neurotransmission impairment.
Donato L, Alibrandi S, Scimone C, Rinaldi C, Dascola A, Calamuneri A, D'Angelo R, Sidoti A. Donato L, et al. PLoS One. 2022 Dec 9;17(12):e0278857. doi: 10.1371/journal.pone.0278857. eCollection 2022. PLoS One. 2022. PMID: 36490268 Free PMC article.
According to relationship with GUCY2D, predicted functional effects, eye localization, and ocular disease affinity, only 9 variants, carried by 6 genes (CACNG8, PAX2, RXRG, CCDC175, PDE4DIP and LTF), survived the filtering. These genes encode key proteins involved in cone …
According to relationship with GUCY2D, predicted functional effects, eye localization, and ocular disease affinity, only 9 variants, carried …