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Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation.
Xu J, Deng X, Gu A, Cai Y, Huang Y, Zhang W, Zhang Y, Wen W, Xie Y. Xu J, et al. Cell Rep. 2023 Jul 25;42(7):112677. doi: 10.1016/j.celrep.2023.112677. Epub 2023 Jun 22. Cell Rep. 2023. PMID: 37352102 Free article.
We find that the interaction with Ccdc85c relieves the intramolecular auto-inhibition of Par3, which leads to PSCP of Par3. ...Furthermore, ectopic activation of Notch signaling rescues RGC proliferation defects caused by the downregulation of Ccdc85c. These results …
We find that the interaction with Ccdc85c relieves the intramolecular auto-inhibition of Par3, which leads to PSCP of Par3. ...Furthe …
CCDC85C suppresses colorectal cancer cells proliferation and metastasis through activating GSK-3beta and promoting beta-catenin degradation.
Hu W, Shen J, Tao Y, Dong D, Lu S, Li L, Sun D, Fan M, Xu C, Shen W, Yu C, Cheng H. Hu W, et al. Cell Signal. 2023 Sep;109:110799. doi: 10.1016/j.cellsig.2023.110799. Epub 2023 Jul 9. Cell Signal. 2023. PMID: 37433398 Free article.
This study aimed to determine the effect of CCDC85C on Colorectal Cancer (CRC) progression and to explore the related mechanism. pLV-PURO plasmid was used to construct CCDC85C-overexpressing cells while CRISPR-CasRx was used to construct CCDC85C knockdown cel …
This study aimed to determine the effect of CCDC85C on Colorectal Cancer (CRC) progression and to explore the related mechanism. pLV- …
Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats.
Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M. Hasan MM, et al. Exp Anim. 2022 Feb 9;71(1):100-108. doi: 10.1538/expanim.21-0132. Epub 2021 Dec 23. Exp Anim. 2022. PMID: 34657927 Free PMC article.
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for genetic hydrocephalus and subcortical heterotopia with frequent brain hemorrhage. ...Our chronological study will help to relate CCDC85C protein with intermediate filaments to elucidate the detailed …
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for genetic hydrocephalus and subcortical heterotopia with frequent b …
Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
Konishi S, Tanaka N, Mashimo T, Yamamoto T, Sakuma T, Kaneko T, Tanaka M, Izawa T, Yamate J, Kuwamura M. Konishi S, et al. Exp Anim. 2020 Jan 29;69(1):26-33. doi: 10.1538/expanim.19-0005. Epub 2019 Jul 23. Exp Anim. 2020. PMID: 31341137 Free PMC article.
Spontaneous hhy mice show hydrocephalus and subcortical heterotopia, and a mutation in the Ccdc85c gene has been identified. To contribute to the comparison of the role of Ccdc85c in different species, we established a Ccdc85c KO rat and investigated its path …
Spontaneous hhy mice show hydrocephalus and subcortical heterotopia, and a mutation in the Ccdc85c gene has been identified. To contr …
Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats.
Tanaka N, Izawa T, Takenaka S, Yamate J, Kuwamura M. Tanaka N, et al. Histol Histopathol. 2015 Jul;30(7):823-32. doi: 10.14670/HH-11-589. Epub 2015 Feb 2. Histol Histopathol. 2015. PMID: 25644709
Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and expression pattern of Ccdc85C in the systemic developing organs in rats. Ccdc85C was expressed in various simple epithelia but n …
Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and ex …
Disrupted neurogenesis, gliogenesis, and ependymogenesis in the Ccdc85c knockout rat for hydrocephalus model.
Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M. Hasan MM, et al. Cells Dev. 2023 Sep;175:203858. doi: 10.1016/j.cdev.2023.203858. Epub 2023 Jun 2. Cells Dev. 2023. PMID: 37271245 Free article.
Coil-coiled domain containing 85c (Ccdc85c) is a causative gene for congenital hydrocephalus and subcortical heterotopia with frequent brain hemorrhage. We established Ccdc85c knockout (KO) rats and investigated the roles of CCDC85C and intermediate filament …
Coil-coiled domain containing 85c (Ccdc85c) is a causative gene for congenital hydrocephalus and subcortical heterotopia with frequen …
KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated beta-catenin pathway.
Guo Y, Chai B, Jia J, Yang M, Li Y, Zhang R, Wang S, Xu J. Guo Y, et al. Cell Biosci. 2021 Apr 15;11(1):73. doi: 10.1186/s13578-021-00585-6. Cell Biosci. 2021. PMID: 33858520 Free PMC article.
Further, co-IP studies revealed that VPS35 could interact with Ccdc85c in HCC cells. Rescue assay confirmed that overexpression of VPS35 and knockdown of Ccdc85c abolished the VPS35-medicated promotion effect on cell proliferation and invasion. Finally, KLF7/VPS35 a …
Further, co-IP studies revealed that VPS35 could interact with Ccdc85c in HCC cells. Rescue assay confirmed that overexpression of VP …
Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice.
Mori N, Kuwamura M, Tanaka N, Hirano R, Nabe M, Ibuki M, Yamate J. Mori N, et al. Am J Pathol. 2012 Jan;180(1):314-27. doi: 10.1016/j.ajpath.2011.09.014. Epub 2011 Nov 3. Am J Pathol. 2012. PMID: 22056358 Free article.
Here, we show that coiled-coil domain-containing 85C (Ccdc85c), consisting of 6 exons that encode a 420 amino acid protein, is disrupted by replacement of a 3.2-kb sequence, including exon 2 in Ccdc85c by a 1.5-kb retrotransposon-like repeat sequence in the hhy muta …
Here, we show that coiled-coil domain-containing 85C (Ccdc85c), consisting of 6 exons that encode a 420 amino acid protein, is disrup …
Expression of Ccdc85C, a causative protein for murine hydrocephalus, in the mammary gland tumors of dogs.
Tanaka N, Izawa T, Takenaka S, Akiyoshi H, Yamate J, Kuwamura M. Tanaka N, et al. Histol Histopathol. 2017 Apr;32(4):397-403. doi: 10.14670/HH-11-806. Epub 2016 Jul 26. Histol Histopathol. 2017. PMID: 27457231
In canine mammary gland tumors, Ccdc85C was expressed at the apical junctions of the luminal epithelial cells. Ccdc85C was also distributed throughout the entire cytoplasm of the myoepithelial cells. ...Ccdc85C is known to cause neurological diseases such as …
In canine mammary gland tumors, Ccdc85C was expressed at the apical junctions of the luminal epithelial cells. Ccdc85C was als …
Aberrant alpha-smooth muscle actin expression in the lateral ventricle of Ccdc85C knockout rats.
Jannat N, Hasan MM, Tokuno H, Tanaka M, Izawa T, Yamate J, Kuwamura M. Jannat N, et al. Vet Pathol. 2025 Jan 18:3009858241312611. doi: 10.1177/03009858241312611. Online ahead of print. Vet Pathol. 2025. PMID: 39825670
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for genetic hydrocephalus found in hemorrhagic hydrocephalus (hhy) mice. The Ccdc85c knockout (KO) rat has subcortical heterotopia with frequent brain hemorrhage as seen in hhy mice. ...
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for genetic hydrocephalus found in hemorrhagic hydrocephalus (hhy) mi …
15 results