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CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
Sun W, Jin Y, Wei C, Xu Y, Liu W, Zhong J, Zou Z, Lin X, Xiang Y, Chen Y. Sun W, et al. Eur J Cancer. 2023 Jul;188:49-63. doi: 10.1016/j.ejca.2023.04.005. Epub 2023 Apr 20. Eur J Cancer. 2023. PMID: 37196484 Free article.
GeneChip primeview, Ingenuity pathway analysis and bioinformatics analysis combined with co-immunoprecipitation, protein stability experiments and ubiquitination analysis were performed to demonstrate the downstream genes and regulatory mechanism of CDCA2. RESULTS: CDCA …
GeneChip primeview, Ingenuity pathway analysis and bioinformatics analysis combined with co-immunoprecipitation, protein stability experimen …
CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
Li K, Fan T, Shi Z, Jiang H. Li K, et al. Anal Cell Pathol (Amst). 2022 Dec 22;2022:9912254. doi: 10.1155/2022/9912254. eCollection 2022. Anal Cell Pathol (Amst). 2022. PMID: 36588796 Free PMC article.
In this research, we aimed to investigate the function and potential mechanism of CDCA2 in HCC cells. METHODS: Gain- and loss-of-function experiments were conducted to determine the biological function of CDCA2 in HCC cells. ...Inversely, depletion of CDCA2 d …
In this research, we aimed to investigate the function and potential mechanism of CDCA2 in HCC cells. METHODS: Gain- and loss-of-func …
The Role of CDCA2 in tumor genesis, prognosis and future treatments.
Lin X, Zou Z, Zhong J, Wang T, Ma W, Hu T, Sun W, Xu Y, Eggermont AMM, Chen Y. Lin X, et al. Eur J Cancer. 2024 Nov;211:114308. doi: 10.1016/j.ejca.2024.114308. Epub 2024 Sep 6. Eur J Cancer. 2024. PMID: 39288736 Free article. Review.
The Cell Division Cycle Associated 2 (CDCA2) gene is responsible for encoding a targeting subunit of cell-cycle associated protein. ...Additionally, CDCA2 is involved in multiple signaling pathways such as the PI3K/Akt pathway and p53 pathway. ...
The Cell Division Cycle Associated 2 (CDCA2) gene is responsible for encoding a targeting subunit of cell-cycle associated protein. . …
CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
Wang S, Cao K, Liao Y, Zhang W, Zheng J, Li X, Huang M, Zhong Y, Hu X, Chen D, Wang Y. Wang S, et al. Oncogene. 2021 Jun;40(25):4368-4383. doi: 10.1038/s41388-021-01855-w. Epub 2021 Jun 8. Oncogene. 2021. PMID: 34103686
In HCC cells, CDCA2 promotes cell growth and inhibits apoptosis. Mechanistically, CDCA2's transcription is activated through the binding of E2F2/E2F8 with its promoter. ...In conclusion, our results reveal that CDCA2 is a prognostic biomarker for HCC patients …
In HCC cells, CDCA2 promotes cell growth and inhibits apoptosis. Mechanistically, CDCA2's transcription is activated through t …
E2F3/CDCA2 reduces radiosensitivity in gastric adenocarcinoma by activating PI3K/AKT pathway.
Gao J, Wang H, Qiu X, Tang J. Gao J, et al. Br J Radiol. 2023 Dec;96(1152):20230477. doi: 10.1259/bjr.20230477. Epub 2023 Oct 24. Br J Radiol. 2023. PMID: 37750838 Free PMC article.
The impact of CDCA2 on cell proliferation and radiosensitivity was reversed by the PI3K/AKT inhibitor. ...ADVANCES IN KNOWLEDGE: 1. CDCA2 reduced the radiosensitivity of gastric adenocarcinoma cells;2. CDCA2 reduced the radiosensitivity of gastric adenocarcin …
The impact of CDCA2 on cell proliferation and radiosensitivity was reversed by the PI3K/AKT inhibitor. ...ADVANCES IN KNOWLEDGE: 1. …
CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1.
Jin WH, Zhou AT, Chen JJ, Cen Y. Jin WH, et al. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6858-6863. doi: 10.26355/eurrev_202006_21675. Eur Rev Med Pharmacol Sci. 2020. PMID: 32633378 Free article.
At last, rescue experiments were conducted to explore the involvement of CCAD1 in CDCA2-regulated progression of melanoma. RESULTS: CDCA2 was upregulated in melanoma tissues, especially in those with metastasis. Identically, in vitro level of CDCA2 was upregu …
At last, rescue experiments were conducted to explore the involvement of CCAD1 in CDCA2-regulated progression of melanoma. RESULTS: …
CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
Xu B, Chen H, Xu Z, Yao X, Sun X, Cheng H. Xu B, et al. Mol Med Rep. 2021 Jul;24(1):530. doi: 10.3892/mmr.2021.12169. Epub 2021 May 26. Mol Med Rep. 2021. PMID: 34036376 Free PMC article.
Cell division cycle-associated 2 (CDCA2) overexpression has been demonstrated to serve a significant role in tumorigenesis in certain types of cancer. ...Collectively, the results revealed that CDCA2 could serve as an underlying target to regulate tumour growth and …
Cell division cycle-associated 2 (CDCA2) overexpression has been demonstrated to serve a significant role in tumorigenesis in certain …
Increased CDCA2 Level Was Related to Poor Prognosis in Hepatocellular Carcinoma and Associated With Up-Regulation of Immune Checkpoints.
Tang M, Liao M, Ai X, He G. Tang M, et al. Front Med (Lausanne). 2022 Mar 7;8:773724. doi: 10.3389/fmed.2021.773724. eCollection 2021. Front Med (Lausanne). 2022. PMID: 35372372 Free PMC article.
BACKGROUND: Cell division cycle-associated protein 2 (CDCA2) is a member of cell cycle-related proteins. CDCA2 plays a role in the regulation of protein phosphatase 1(PP1) gamma-dependent DNA damage response (DDR) and H3 phosphorylation. ...The prognostic value of …
BACKGROUND: Cell division cycle-associated protein 2 (CDCA2) is a member of cell cycle-related proteins. CDCA2 plays a role in …
Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.
Yu Z, Zhang Y, Shao S, Liu Q, Li Y, Du X, Zhang K, Zhang M, Yuan H, Yuan Q, Liu T, Gao Y, Wang Y, Hong W, Han T. Yu Z, et al. Front Oncol. 2021 Oct 1;11:755814. doi: 10.3389/fonc.2021.755814. eCollection 2021. Front Oncol. 2021. PMID: 34660326 Free PMC article.
Furthermore, CDCA2 was found to be an independent prognostic predictor. An excellent prognostic model of HCC was successfully constructed with CDCA2 in combination with TNM stage. ...Inhibition of p53 signaling and apoptosis was found after overexpression of CDCA …
Furthermore, CDCA2 was found to be an independent prognostic predictor. An excellent prognostic model of HCC was successfully constru …
CDCA2 triggers in vivo and in vitro proliferation of hepatocellular carcinoma by activating the AKT/CCND1 signaling.
Li J, Chen Y, Wang X, Wang C. Li J, et al. J BUON. 2021 May-Jun;26(3):882-888. J BUON. 2021. PMID: 34268949 Free article.
CDCA2 level was related to tumor size, vascular invasion and tumor differentiation in HCC. ...The phosphatidilinositol 3-kinase (PI3K)/Akt was activated by CDCA2 during the progression of HCC. Tumor volume and tumor weight of xenografted HCC decreased in nude mice w …
CDCA2 level was related to tumor size, vascular invasion and tumor differentiation in HCC. ...The phosphatidilinositol 3-kinase (PI3K …
82 results