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198 results

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Page 1
CDK5RAP2 activates microtubule nucleator gammaTuRC by facilitating template formation and actin release.
Serna M, Zimmermann F, Vineethakumari C, Gonzalez-Rodriguez N, Llorca O, Lüders J. Serna M, et al. Dev Cell. 2024 Dec 2;59(23):3175-3188.e8. doi: 10.1016/j.devcel.2024.09.001. Epub 2024 Sep 24. Dev Cell. 2024. PMID: 39321809
Here, we identify the mechanism of gammaTuRC activation by CDK5RAP2 centrosomin motif 1 (CM1). Using cryoelectron microscopy (cryo-EM), we find that activation involves binding of multiple CM1 dimers to five distinct sites around the outside of the gammaTuRC cone, which cr …
Here, we identify the mechanism of gammaTuRC activation by CDK5RAP2 centrosomin motif 1 (CM1). Using cryoelectron microscopy (cryo-EM …
CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3beta/beta-catenin-WIP1 pathway.
Wang X, Sipila P, Si Z, Rosales JL, Gao X, Lee KY. Wang X, et al. Cell Death Dis. 2021 Dec 20;13(1):9. doi: 10.1038/s41419-021-04457-2. Cell Death Dis. 2021. PMID: 34930892 Free PMC article.
Here, we demonstrate that knocking down CDK5RAP2 in human fibroblasts triggers premature cell senescence that is recapitulated in Cdk5rap2(an/an) mouse embryonic fibroblasts and embryos, which exhibit reduced body weight and size, and increased senescence-associated …
Here, we demonstrate that knocking down CDK5RAP2 in human fibroblasts triggers premature cell senescence that is recapitulated in …
CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma.
Shen Y, Chen Y, Lin Y, Li Y, Liu P, Zhang B, Wang Y, Chan KC, Mak NK, Kahn M, Qi RZ, Yang H. Shen Y, et al. Cell Death Dis. 2023 Feb 11;14(2):107. doi: 10.1038/s41419-023-05652-z. Cell Death Dis. 2023. PMID: 36774351 Free PMC article.
The expression of CDK5RAP2 is regulated by the Wnt signaling pathway. Depletion of CDK5RAP2 inhibits the tumorigenesis and migration of OSCC cells and alters the OSCC cancer stem (-like) cell (CSC) signature. Notably, suppression of CDK5RAP2 expression disrup …
The expression of CDK5RAP2 is regulated by the Wnt signaling pathway. Depletion of CDK5RAP2 inhibits the tumorigenesis and mig …
Cdk5rap2 exposes the centrosomal root of microcephaly syndromes.
Megraw TL, Sharkey JT, Nowakowski RS. Megraw TL, et al. Trends Cell Biol. 2011 Aug;21(8):470-80. doi: 10.1016/j.tcb.2011.04.007. Epub 2011 May 31. Trends Cell Biol. 2011. PMID: 21632253 Free PMC article. Review.
The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role in neural progenitor proliferation and in maintaining normal centriole replication control. ...We integrate the impact of centriole replica …
The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role …
Congenital microcephaly-linked CDK5RAP2 affects eye development.
Zaqout S, Ravindran E, Stoltenburg-Didinger G, Kaindl AM. Zaqout S, et al. Ann Hum Genet. 2020 Jan;84(1):87-91. doi: 10.1111/ahg.12343. Epub 2019 Jul 29. Ann Hum Genet. 2020. PMID: 31355417
Given the lack of a further pedigree with this phenotype, it remained unclear whether this was a true causal relationship. Here we support the link between CDK5RAP2 and eye development by showing that most Cdk5rap2 mutant mice (an/an) exhibit eye malformations rangi …
Given the lack of a further pedigree with this phenotype, it remained unclear whether this was a true causal relationship. Here we support t …
MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer.
He Y, Shao Y, Zhou Z, Li T, Gao Y, Liu X, Yuan G, Yang G, Zhang L, Li F. He Y, et al. Cell Death Dis. 2024 Jul 24;15(7):530. doi: 10.1038/s41419-024-06908-y. Cell Death Dis. 2024. PMID: 39048555 Free PMC article.
Here, we find that Microrchidia family CW-type zinc finger 2 (MORC2) binds to RRM1 domain of RNA binding motif protein 39 (RBM39), and RBM39 interacts with site 1 of pre-CDK5RAP2 exon 32 via its UHM domain, resulting in a splicing switch of cyclin-dependent kinase 5 regula …
Here, we find that Microrchidia family CW-type zinc finger 2 (MORC2) binds to RRM1 domain of RNA binding motif protein 39 (RBM39), and RBM39 …
What's the hype about CDK5RAP2?
Kraemer N, Issa L, Hauck SC, Mani S, Ninnemann O, Kaindl AM. Kraemer N, et al. Cell Mol Life Sci. 2011 May;68(10):1719-36. doi: 10.1007/s00018-011-0635-4. Epub 2011 Feb 17. Cell Mol Life Sci. 2011. PMID: 21327915 Free PMC article. Review.
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. ...Here, we provide a timely overview of the curre …
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the dis …
Partial closure of the gamma-tubulin ring complex by CDK5RAP2 activates microtubule nucleation.
Xu Y, Muñoz-Hernández H, Krutyhołowa R, Marxer F, Cetin F, Wieczorek M. Xu Y, et al. Dev Cell. 2024 Dec 2;59(23):3161-3174.e15. doi: 10.1016/j.devcel.2024.09.002. Epub 2024 Sep 24. Dev Cell. 2024. PMID: 39321808 Free article.
Here, we determined the structure of the porcine gamma-TuRC purified using CDK5RAP2's centrosomin motif 1 (CM1). We identified an unexpected conformation of the gamma-TuRC bound to multiple protein modules containing MZT2, GCP2, and CDK5RAP2, resulting in a long-ran …
Here, we determined the structure of the porcine gamma-TuRC purified using CDK5RAP2's centrosomin motif 1 (CM1). We identified an une …
CDK5RAP2 primary microcephaly is associated with hypothalamic, retinal and cochlear developmental defects.
Nasser H, Vera L, Elmaleh-Bergès M, Steindl K, Letard P, Teissier N, Ernault A, Guimiot F, Afenjar A, Moutard ML, Héron D, Alembik Y, Momtchilova M, Milani P, Kubis N, Pouvreau N, Zollino M, Guilmin Crepon S, Kaguelidou F, Gressens P, Verloes A, Rauch A, El Ghouzzi V, Drunat S, Passemard S. Nasser H, et al. J Med Genet. 2020 Jun;57(6):389-399. doi: 10.1136/jmedgenet-2019-106474. Epub 2020 Feb 3. J Med Genet. 2020. PMID: 32015000 Clinical Trial.
CONCLUSION: This is the first report indicating that CDK5RAP2 not only governs brain size but also plays a role in ocular and cochlear development and is necessary for hypothalamic nuclear separation at the midline. Our data indicate that CDK5RAP2 should be consider …
CONCLUSION: This is the first report indicating that CDK5RAP2 not only governs brain size but also plays a role in ocular and cochlea …
A novel missense variant in CDK5RAP2 associated with non-obstructive azoospermia.
Rahimian M, Askari M, Salehi N, Riccio A, Jaafarinia M, Almadani N, Totonchi M. Rahimian M, et al. Taiwan J Obstet Gynecol. 2023 Nov;62(6):830-837. doi: 10.1016/j.tjog.2023.03.015. Taiwan J Obstet Gynecol. 2023. PMID: 38008501 Free article.
As a consequence of the R1335W mutation, the positively charged Arginine was replaced by to the hydrophobic tryptophan residue, possibly leading to local instability in the structure and perturbation in the CDK5RAP2-MAPRE1 interaction. CONCLUSION: Our study reports a novel …
As a consequence of the R1335W mutation, the positively charged Arginine was replaced by to the hydrophobic tryptophan residue, possibly lea …
198 results