Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells.
Shi J, Wu W, Chen D, Liao Z, Sheng T, Wang Y, Yao Y, Wu Q, Liu F, Zhou R, Zhu C, Shen X, Mao Z, Ding Y, Wang W, Dotti G, Sun J, Liang X, Fang W, Zhao P, Li H, Gu Z.
Shi J, et al. Among authors: zhao p.
Nat Mater. 2024 Jun;23(6):844-853. doi: 10.1038/s41563-024-01825-z. Epub 2024 Mar 6.
Nat Mater. 2024.
PMID: 38448658
Here we show that implanted patient-derived freeze-dried lymph nodes loaded with chimeric antigen receptor T cells improve delivery to solid tumours and inhibit tumour recurrence after surgery. Chimeric antigen receptor T cells can be effectively loaded into lyophilized ly …
Here we show that implanted patient-derived freeze-dried lymph nodes loaded with chimeric antigen receptor T cells improve delivery to solid …