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Page 1
A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.
Ualiyeva S, Lemire E, Wong C, Perniss A, Boyd AA, Avilés EC, Minichetti DG, Maxfield A, Roditi R, Matsumoto I, Wang X, Deng W, Barrett NA, Buchheit KM, Laidlaw TM, Boyce JA, Bankova LG, Haber AL. Ualiyeva S, et al. Sci Immunol. 2024 Feb 2;9(92):eabq4341. doi: 10.1126/sciimmunol.abq4341. Epub 2024 Feb 2. Sci Immunol. 2024. PMID: 38306414 Free PMC article.
Inhalation of Alternaria induced mucosal epithelial effector molecules including Chil4 and a distinct pathway leading to proliferation of the quiescent olfactory horizontal basal stem cell (HBC) pool, both triggered in the absence of olfactory apoptosis. ...
Inhalation of Alternaria induced mucosal epithelial effector molecules including Chil4 and a distinct pathway leading to proliferatio …
Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Wang L, Ren W, Li X, Zhang X, Tian H, Bhattarai JP, Challis RC, Lee AC, Zhao S, Yu H, Ma M, Yu Y. Wang L, et al. J Neurosci. 2021 Jun 30;41(26):5620-5637. doi: 10.1523/JNEUROSCI.1601-20.2021. Epub 2021 May 20. J Neurosci. 2021. PMID: 34016714 Free PMC article.
In this study, we elucidated a novel role of Ym2 (also known as Chil4 or Chi3l4), a chitinase-like protein expressed in supporting cells, in regulating regeneration of the injured OE in vivo in both male and female mice and cell proliferation/differentiation in OE colonies …
In this study, we elucidated a novel role of Ym2 (also known as Chil4 or Chi3l4), a chitinase-like protein expressed in supporting ce …
Ym1 protein crystals promote type 2 immunity.
Heyndrickx I, Deswarte K, Verstraete K, Verschueren KHG, Smole U, Aegerter H, Dansercoer A, Hammad H, Savvides SN, Lambrecht BN. Heyndrickx I, et al. Elife. 2024 Jan 9;12:RP90676. doi: 10.7554/eLife.90676. Elife. 2024. PMID: 38194250 Free PMC article.
Although mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-like proteins Ym1 and/or Ym2, encoded by Chil3 and Chil4 and made by myeloid and epithelial cells respectively. Here, we investigated the biological effects of pseudo-CLCs …
Although mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-like proteins Ym1 and/or Ym2, encoded b …
Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis.
Wu T, Li W, Zhuang L, Liu J, Wang P, Gu Y, Liu Y, Yu Y. Wu T, et al. Cell Prolif. 2025 May 19:e70055. doi: 10.1111/cpr.70055. Online ahead of print. Cell Prolif. 2025. PMID: 40389328
Here, we found that Chil4 is upregulated in the aged OE. Deletion of Chil4 leads to a reduction in the number of GBCs and immature OSNs (iOSNs). ...Chil4 downregulation in aged organoids reduced the number of mature sensory neurons, suggesting a necessary rol …
Here, we found that Chil4 is upregulated in the aged OE. Deletion of Chil4 leads to a reduction in the number of GBCs and imma …
Targeted delivery of Chil3/Chil4 siRNA to alveolar macrophages using ternary complexes composed of HMG and oligoarginine micelles.
Choi M , Jeong H , Kim S , Kim M , Lee M , Rhim T . Choi M , et al. Nanoscale. 2020 Jan 2;12(2):933-943. doi: 10.1039/c9nr06382j. Nanoscale. 2020. PMID: 31840707
In this study, targeted delivery of Chil3 and Chil4 siRNA to activated macrophages was developed using a ligand called high mobility group (HMG) and oligoarginine (OR) micelles. ...In addition, intratracheal administration of siRNA/HMG/OR ternary complexes delivered Chil3 …
In this study, targeted delivery of Chil3 and Chil4 siRNA to activated macrophages was developed using a ligand called high mobility …
Evaluation of chickens infected with a recombinant virulent NDV clone expressing chicken IL4.
Marcano VC, Susta L, Diel DG, Cardenas-Garcia S, Miller PJ, Afonso CL, Brown CC. Marcano VC, et al. Microb Pathog. 2021 Oct;159:105116. doi: 10.1016/j.micpath.2021.105116. Epub 2021 Jul 31. Microb Pathog. 2021. PMID: 34339794
To assess the role of chIL4 in velogenic NDV pathogenesis we created a vNDV infectious clone expressing chIL4. ...In addition, chIL4 signal was found in all tissues of rZJ1-IL4 birds at 5DPI. CONCLUSIONS: The production of chIL4 by a recombinant NDV st …
To assess the role of chIL4 in velogenic NDV pathogenesis we created a vNDV infectious clone expressing chIL4. ...In addition, …
STAT6-induced production of mucus and resistin-like molecules in lung Club cells does not protect against helminth or influenza A virus infection.
Ruhl A, Antão AV, Dietschmann A, Radtke D, Tenbusch M, Voehringer D. Ruhl A, et al. Eur J Immunol. 2024 Jan;54(1):e2350558. doi: 10.1002/eji.202350558. Epub 2023 Oct 25. Eur J Immunol. 2024. PMID: 37855177 Free article.
CCSP-Cre_STAT6vt mice and bronchiolar organoids derived from these show an enhanced expression of the chitinase-like protein Chil4 (Ym2) and resistin-like molecules (Relm-alpha, -beta, -gamma). In addition, goblet cells of these mice spontaneously secrete mucus into the br …
CCSP-Cre_STAT6vt mice and bronchiolar organoids derived from these show an enhanced expression of the chitinase-like protein Chil4 (Y …
Impact of Newcastle disease virus vaccines and genetic variations on interleukin-4 activation in broiler chicken.
Edan RJ, Jumaa RS. Edan RJ, et al. Open Vet J. 2025 Jan;15(1):388-394. doi: 10.5455/OVJ.2025.v15.i1.34. Epub 2025 Jan 31. Open Vet J. 2025. PMID: 40092172 Free PMC article.
RESULTS: Group K showed a gradual increase in ChIL4 levels from 11.19 0.17 to 13.70 0.38, while Group L exhibited an initial increase on day 15 followed by stabilization on days 25 and 35. ...CONCLUSION: These findings suggest that genetic variations, particularly SNPs, ma …
RESULTS: Group K showed a gradual increase in ChIL4 levels from 11.19 0.17 to 13.70 0.38, while Group L exhibited an initial increase …
Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.
Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ong CB, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):331-40. doi: 10.1165/rcmb.2015-0165OC. Am J Respir Cell Mol Biol. 2016. PMID: 26203683
In contrast, 9-day ozone exposure elicited type 2 immune responses in C57BL/6 mice, with mucosal mRNA overexpression of Arg1, Ccl8 (MCP-2), Ccl11, Chil4 (Ym2), Clca1 (Gob5), Il5, Il10, and Il13; increased density of mucosal eosinophils; and nasal epithelial remodeling (e.g …
In contrast, 9-day ozone exposure elicited type 2 immune responses in C57BL/6 mice, with mucosal mRNA overexpression of Arg1, Ccl8 (MCP-2), …
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.
Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Lozano-Pope I, et al. BMC Cancer. 2017 Feb 15;17(1):133. doi: 10.1186/s12885-017-3114-y. BMC Cancer. 2017. PMID: 28201999 Free PMC article.
The most significant differentially upregulated gene during Helicobacter infection in Myd88 (-/-) mice was chitinase-like 4 (chil4), which is involved in tissue remodeling and wound healing. Other highly upregulated genes in H. felis-infected Myd88 (-/-) mice included, Ind …
The most significant differentially upregulated gene during Helicobacter infection in Myd88 (-/-) mice was chitinase-like 4 (chil4), …
16 results