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Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology.

Patton AL, Seely KA, Chimalakonda KC, Tran JP, Trass M, Miranda A, Fantegrossi WE, Kennedy PD, Dobrowolski P, Radominska-Pandya A, McCain KR, James LP, Endres GW, Moran JH. Patton AL, et al. Among authors: chimalakonda kc. Anal Chem. 2013 Oct 1;85(19):9390-9. doi: 10.1021/ac4024704. Epub 2013 Sep 12. Anal Chem. 2013. PMID: 23987522

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Sulfaphenazole and α-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/spice.

Chimalakonda KC, James LP, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Drug Metab Lett. 2013 Mar;7(1):34-8. doi: 10.2174/187231280701131211151523. Drug Metab Lett. 2013. PMID: 24329780 Free PMC article.

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Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine.

Moran CL, Le VH, Chimalakonda KC, Smedley AL, Lackey FD, Owen SN, Kennedy PD, Endres GW, Ciske FL, Kramer JB, Kornilov AM, Bratton LD, Dobrowolski PJ, Wessinger WD, Fantegrossi WE, Prather PL, James LP, Radominska-Pandya A, Moran JH. Moran CL, et al. Among authors: chimalakonda kc. Anal Chem. 2011 Jun 1;83(11):4228-36. doi: 10.1021/ac2005636. Epub 2011 May 6. Anal Chem. 2011. PMID: 21506519 Free PMC article.

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Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.

Chimalakonda KC, Bratton SM, Le VH, Yiew KH, Dineva A, Moran CL, James LP, Moran JH, Radominska-Pandya A. Chimalakonda KC, et al. Drug Metab Dispos. 2011 Oct;39(10):1967-76. doi: 10.1124/dmd.111.040709. Epub 2011 Jul 11. Drug Metab Dispos. 2011. PMID: 21746969 Free PMC article.

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K2 toxicity: fatal case of psychiatric complications following AM2201 exposure.

Patton AL, Chimalakonda KC, Moran CL, McCain KR, Radominska-Pandya A, James LP, Kokes C, Moran JH. Patton AL, et al. Among authors: chimalakonda kc. J Forensic Sci. 2013 Nov;58(6):1676-80. doi: 10.1111/1556-4029.12216. Epub 2013 Jul 3. J Forensic Sci. 2013. PMID: 23822805 Free PMC article.

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Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release.

Chimalakonda KC, Pang E, Weaver JL, Howard KE, Patel V, Boyne MT 2nd. Chimalakonda KC, et al. J Pharm Biomed Anal. 2015 Jan;102:494-9. doi: 10.1016/j.jpba.2014.10.016. Epub 2014 Oct 23. J Pharm Biomed Anal. 2015. PMID: 25459949

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Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Drug Metab Dispos. 2012 Nov;40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17. Drug Metab Dispos. 2012. PMID: 22904561 Free PMC article.

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Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver.

Chimalakonda KC, Agarwal HK, Kumar A, Parang K, Mehvar R. Chimalakonda KC, et al. Bioconjug Chem. 2007 Nov-Dec;18(6):2097-108. doi: 10.1021/bc700193d. Epub 2007 Oct 9. Bioconjug Chem. 2007. PMID: 17922546

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Development and validation of an LC-MS/MS method for determination of phencyclidine in human serum and its application to human drug abuse cases.

Chimalakonda KC, Hailey C, Black R, Beekman A, Carlisle R, Lowman-Smith E, Singletary H, Owens SM, Hendrickson H. Chimalakonda KC, et al. Anal Methods. 2010 Sep 1;2(9):1249-1254. doi: 10.1039/C0AY00206B. Anal Methods. 2010. PMID: 20959870 Free PMC article.

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Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine.

Chimalakonda KC, Moran CL, Kennedy PD, Endres GW, Uzieblo A, Dobrowolski PJ, Fifer EK, Lapoint J, Nelson LS, Hoffman RS, James LP, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Anal Chem. 2011 Aug 15;83(16):6381-8. doi: 10.1021/ac201377m. Epub 2011 Jul 27. Anal Chem. 2011. PMID: 21740038 Free PMC article.

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