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Page 1
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
He D, Feng H, Sundberg B, Yang J, Powers J, Christian AH, Wilkinson JE, Monnin C, Avizonis D, Thomas CJ, Friedman RA, Kluger MD, Hollingsworth MA, Grandgenett PM, Klute KA, Toste FD, Chang CJ, Chio IIC. He D, et al. Among authors: christian ah. Mol Cell. 2022 Aug 18;82(16):3045-3060.e11. doi: 10.1016/j.molcel.2022.06.005. Epub 2022 Jun 24. Mol Cell. 2022. PMID: 35752173 Free PMC article.
Scaffold hopping by net photochemical carbon deletion of azaarenes.
Woo J, Christian AH, Burgess SA, Jiang Y, Mansoor UF, Levin MD. Woo J, et al. Among authors: christian ah. Science. 2022 Apr 29;376(6592):527-532. doi: 10.1126/science.abo4282. Epub 2022 Apr 28. Science. 2022. PMID: 35482853 Free PMC article.
An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4.
Gonzalez-Valero A, Reeves AG, Page ACS, Moon PJ, Miller E, Coulonval K, Crossley SWM, Xie X, He D, Musacchio PZ, Christian AH, McKenna JM, Lewis RA, Fang E, Dovala D, Lu Y, McGregor LM, Schirle M, Tallarico JA, Roger PP, Toste FD, Chang CJ. Gonzalez-Valero A, et al. Among authors: christian ah. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9. J Am Chem Soc. 2022. PMID: 36484997 Free PMC article.
20 results