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Interleukin-2 superkines by computational design.
Ren J, Chu AE, Jude KM, Picton LK, Kare AJ, Su L, Montano Romero A, Huang PS, Garcia KC. Ren J, et al. Among authors: chu ae. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117401119. doi: 10.1073/pnas.2117401119. Epub 2022 Mar 16. Proc Natl Acad Sci U S A. 2022. PMID: 35294290 Free PMC article.
An all-atom protein generative model.
Chu AE, Cheng L, Nesr GE, Xu M, Huang PS. Chu AE, et al. bioRxiv [Preprint]. 2023 May 25:2023.05.24.542194. doi: 10.1101/2023.05.24.542194. bioRxiv. 2023. PMID: 37292974 Free PMC article. Preprint.
Sparks of function by de novo protein design.
Chu AE, Lu T, Huang PS. Chu AE, et al. Nat Biotechnol. 2024 Feb;42(2):203-215. doi: 10.1038/s41587-024-02133-2. Epub 2024 Feb 15. Nat Biotechnol. 2024. PMID: 38361073 Review.
Optical control of fast and processive engineered myosins in vitro and in living cells.
Ruijgrok PV, Ghosh RP, Zemsky S, Nakamura M, Gong R, Ning L, Chen R, Vachharajani VT, Chu AE, Anand N, Eguchi RR, Huang PS, Lin MZ, Alushin GM, Liphardt JT, Bryant Z. Ruijgrok PV, et al. Among authors: chu ae. Nat Chem Biol. 2021 May;17(5):540-548. doi: 10.1038/s41589-021-00740-7. Epub 2021 Feb 18. Nat Chem Biol. 2021. PMID: 33603247 Free PMC article.