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DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA. Johnson DC, et al. Among authors: chui aj. Nat Med. 2018 Aug;24(8):1151-1156. doi: 10.1038/s41591-018-0082-y. Epub 2018 Jul 2. Nat Med. 2018. PMID: 29967349 Free PMC article.
N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, Covelli DJ, You S, Cross JR, Bachovchin DA. Rao SD, et al. Among authors: chui aj. Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165443 Free PMC article.
Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.
Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Okondo MC, et al. Among authors: chui aj. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. Cell Chem Biol. 2018. PMID: 29396289 Free PMC article.
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Orth-He EL, et al. Among authors: chui aj. Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649711 Free PMC article.
Activation of the CARD8 Inflammasome Requires a Disordered Region.
Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Chui AJ, et al. Cell Rep. 2020 Oct 13;33(2):108264. doi: 10.1016/j.celrep.2020.108264. Cell Rep. 2020. PMID: 33053349 Free PMC article.
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Okondo MC, Johnson DC, Sridharan R, Go EB, Chui AJ, Wang MS, Poplawski SE, Wu W, Liu Y, Lai JH, Sanford DG, Arciprete MO, Golub TR, Bachovchin WW, Bachovchin DA. Okondo MC, et al. Among authors: chui aj. Nat Chem Biol. 2017 Jan;13(1):46-53. doi: 10.1038/nchembio.2229. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820798 Free PMC article.
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