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1,405 results

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Page 1
The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy.
Forlani G, Shallak M, Gatta A, Shaik AKB, Accolla RS. Forlani G, et al. Biomed J. 2023 Oct;46(5):100631. doi: 10.1016/j.bj.2023.100631. Epub 2023 Jul 17. Biomed J. 2023. PMID: 37467968 Free PMC article. Review.
In this review, we will focus on the MHC class II transactivator (CIITA), the master regulator of MHC class II (MHC-II) gene expression and the founding member of NLR. ...The description of the discovery of CIITA and the genetic and molecular characterization of its …
In this review, we will focus on the MHC class II transactivator (CIITA), the master regulator of MHC class II (MHC-II) gene expressi …
CIITA-modified glioblastomas vaccinate and induce cross-protection against heterologous wild-type glioblastomas.
Gatta A, Shaik AKB, Shallak M, Chiaravalli AM, Cerati M, La Rosa S, Accolla RS, Forlani G. Gatta A, et al. J Transl Med. 2025 Jul 8;23(1):758. doi: 10.1186/s12967-025-06816-5. J Transl Med. 2025. PMID: 40629415 Free PMC article.
The efficacy of the CIITA-based vaccination strategy has been previously demonstrated using the GL261 murine GBM model. ...METHODS: To assess tumor growth and immune response, immunocompetent mice were injected intracranially with either CT-2A or CIITA-modified CT-2 …
The efficacy of the CIITA-based vaccination strategy has been previously demonstrated using the GL261 murine GBM model. ...METHODS: T …
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression.
Rane G, Kuan VLS, Wang S, Mok MMH, Khanchandani V, Hansen J, Norvaisaite I, Zulkaflee N, Yong WK, Jahn A, Mukundan VT, Shi Y, Osato M, Li F, Kappei D. Rane G, et al. EMBO J. 2024 Dec;43(24):6236-6263. doi: 10.1038/s44318-024-00306-y. Epub 2024 Nov 19. EMBO J. 2024. PMID: 39562739 Free PMC article.
Transcriptional regulation of CIITA by ZBTB48 is enabled by ZBTB48-dependent chromatin opening at CIITA pIII upstream of activating H3K4me3 marks. We conclude that ZBTB48 primes CIITA pIII by acting as a molecular on-off-switch for B-cell-specific CIITA …
Transcriptional regulation of CIITA by ZBTB48 is enabled by ZBTB48-dependent chromatin opening at CIITA pIII upstream of activ …
The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.
León Machado JA, Steimle V. León Machado JA, et al. Int J Mol Sci. 2021 Jan 22;22(3):1074. doi: 10.3390/ijms22031074. Int J Mol Sci. 2021. PMID: 33499042 Free PMC article. Review.
In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat (NLR) prote …
In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator …
Osteocyte CIITA aggravates osteolytic bone lesions in myeloma.
Liu H, He J, Bagheri-Yarmand R, Li Z, Liu R, Wang Z, Bach DH, Huang YH, Lin P, Guise TA, Gagel RF, Yang J. Liu H, et al. Nat Commun. 2022 Jun 27;13(1):3684. doi: 10.1038/s41467-022-31356-7. Nat Commun. 2022. PMID: 35760800 Free PMC article.
Here, we demonstrate that the osteocyte-expressed major histocompatibility complex class II transactivator (CIITA) contributes to myeloma-induced bone lesions. CIITA upregulates the secretion of osteolytic cytokines from osteocytes through acetylation at histone 3 l …
Here, we demonstrate that the osteocyte-expressed major histocompatibility complex class II transactivator (CIITA) contributes to mye …
Epigenetic regulation of MHC-II and CIITA genes.
Wright KL, Ting JP. Wright KL, et al. Trends Immunol. 2006 Sep;27(9):405-12. doi: 10.1016/j.it.2006.07.007. Epub 2006 Jul 25. Trends Immunol. 2006. PMID: 16870508 Review.
The interactions of chromatin-modifying enzymes with class II transactivator (CIITA) and relevant DNA-binding proteins for activating and silencing MHC-II gene transcription will be reviewed. Second, the transcriptional control of the promoter of CIITA, the master r …
The interactions of chromatin-modifying enzymes with class II transactivator (CIITA) and relevant DNA-binding proteins for activating …
Novel missense variant of CIITA contributing to endometriosis.
Zhu Y, Pan H, Han Y, Li T, Liu K, Wang B. Zhu Y, et al. Reprod Biomed Online. 2022 Sep;45(3):544-551. doi: 10.1016/j.rbmo.2022.05.011. Epub 2022 May 21. Reprod Biomed Online. 2022. PMID: 35835655
This variant was absent from all public databases. Another two rare missense variants of CIITA (c.1031G>T;p.Arg344Leu and c.1535T>C;p.Leu512Pro) were identified in two unrelated endometriosis patients. ...CONCLUSIONS: The present study demonstrates that CIITA …
This variant was absent from all public databases. Another two rare missense variants of CIITA (c.1031G>T;p.Arg344Leu and c.1535T& …
Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1.
Forlani G, Shallak M, Ramia E, Tedeschi A, Accolla RS. Forlani G, et al. Retrovirology. 2019 Nov 29;16(1):34. doi: 10.1186/s12977-019-0498-6. Retrovirology. 2019. PMID: 31783769 Free PMC article. Review.
We describe the multiple molecular mechanisms through which CIITA exerts its restriction on retroviruses. Of relevance, we review the unprecedented findings pointing to a concerted action of several restriction factors such as CIITA, TRIM22 and TRIM19/PML in synergi …
We describe the multiple molecular mechanisms through which CIITA exerts its restriction on retroviruses. Of relevance, we review the …
IL-1beta-mediated suppression of CIITA attenuates IFN-gamma-induced MHC-II expression on Fibroblasts.
Chen L, Jiang H, Tan B, Geng R, Chen J, Wu S, Fang Z, Lang Y, Ma H, Zheng X, Jiang J. Chen L, et al. Cell Commun Signal. 2025 Dec 10;24(1):25. doi: 10.1186/s12964-025-02575-4. Cell Commun Signal. 2025. PMID: 41366425 Free PMC article.
To dissect transcriptional regulation, we generated CIITA-overexpressing and CIITA-deficient fibroblast lines by lentiviral transduction and CRISPR/Cas9-mediated editing. ...Functional assays confirmed that CIITA was indispensable for IFN-gamma-driven MHC-II …
To dissect transcriptional regulation, we generated CIITA-overexpressing and CIITA-deficient fibroblast lines by lentiviral tr …
1,405 results