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Portfolio selection and management in pharmaceutical research and development: issues and challenges.

Cioffe C. Cioffe C. Clin Pharmacol Ther. 2011 Feb;89(2):300-3. doi: 10.1038/clpt.2010.289. Epub 2010 Dec 22. Clin Pharmacol Ther. 2011. PMID: 21178988 No abstract available.

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Proximal-tubule-like epithelium in Bowman's capsule in spontaneously hypertensive rats. Changes with age.

Haensly WE, Granger HJ, Morris AC, Cioffe C. Haensly WE, et al. Among authors: cioffe c. Am J Pathol. 1982 Apr;107(1):92-7. Am J Pathol. 1982. PMID: 7065126 Free PMC article.

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The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

Saukkonen K, Sande S, Cioffe C, Wolpe S, Sherry B, Cerami A, Tuomanen E. Saukkonen K, et al. Among authors: cioffe c. J Exp Med. 1990 Feb 1;171(2):439-48. doi: 10.1084/jem.171.2.439. J Exp Med. 1990. PMID: 2406363 Free PMC article.

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L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey.

Forrest MJ, Hom G, Bach T, Candelore MR, Cascieri MA, Strader C, Tota L, Fisher MH, Szumiloski J, Ok HO, Weber AE, Wyvratt M, Vicario P, Marko O, Deng L, Cioffe C, Hegarty-Friscino B, MacIntyre E. Forrest MJ, et al. Among authors: cioffe c. Eur J Pharmacol. 2000 Oct 27;407(1-2):175-81. doi: 10.1016/s0014-2999(00)00724-x. Eur J Pharmacol. 2000. PMID: 11050305

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PCR detection of colonization by Helicobacter pylori in conventional, euthymic mice based on the 16S ribosomal gene sequence.

Smith JG, Kong L, Abruzzo GK, Gill CJ, Flattery AM, Scott PM, Bramhill D, Cioffe C, Thompson CM, Bartizal K. Smith JG, et al. Among authors: cioffe c. Clin Diagn Lab Immunol. 1996 Jan;3(1):66-72. doi: 10.1128/cdli.3.1.66-72.1996. Clin Diagn Lab Immunol. 1996. PMID: 8770506 Free PMC article.

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Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

Tuomanen EI, Saukkonen K, Sande S, Cioffe C, Wright SD. Tuomanen EI, et al. Among authors: cioffe c. J Exp Med. 1989 Sep 1;170(3):959-69. doi: 10.1084/jem.170.3.959. J Exp Med. 1989. PMID: 2570120 Free PMC article.

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Pharmacokinetics of fluconazole in cerebrospinal fluid and serum of rabbits: validation of an animal model used to measure drug concentrations in cerebrospinal fluid.

Madu A, Cioffe C, Mian U, Burroughs M, Tuomanen E, Mayers M, Schwartz E, Miller M. Madu A, et al. Among authors: cioffe c. Antimicrob Agents Chemother. 1994 Sep;38(9):2111-5. doi: 10.1128/AAC.38.9.2111. Antimicrob Agents Chemother. 1994. PMID: 7811028 Free PMC article.

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Orally active inhibitors of human leukocyte elastase. I. Disposition of L-683,845 in rats and rhesus monkeys.

Vincent SH, Painter SK, Krieter PA, Colletti AE, Lyszack E, Rosegay A, Dean D, Luffer-Atlas D, Miller RR, Cioffe C, Chiu SH. Vincent SH, et al. Among authors: cioffe c. Drug Metab Dispos. 1996 Dec;24(12):1369-77. Drug Metab Dispos. 1996. PMID: 8971144

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A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.

Kong L, Smith JG, Bramhill D, Abruzzo GK, Bonfiglio C, Cioffe C, Flattery AM, Gill CJ, Lynch L, Scott PM, Silver L, Thompson C, Kropp H, Bartizal K. Kong L, et al. Among authors: cioffe c. Clin Diagn Lab Immunol. 1996 Jan;3(1):73-8. doi: 10.1128/cdli.3.1.73-78.1996. Clin Diagn Lab Immunol. 1996. PMID: 8770507 Free PMC article.

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Orally active inhibitors of human leukocyte elastase. II. Disposition of L-694,458 in rats and rhesus monkeys.

Vincent SH, Painter SK, Luffer-Atlas D, Karanam BV, McGowan E, Cioffe C, Doss G, Chiu SH. Vincent SH, et al. Among authors: cioffe c. Drug Metab Dispos. 1997 Aug;25(8):932-9. Drug Metab Dispos. 1997. PMID: 9280401

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