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Glycine transporter-1 inhibitors: a patent review (2011-2016).

Cioffi CL. Cioffi CL. Expert Opin Ther Pat. 2018 Mar;28(3):197-210. doi: 10.1080/13543776.2018.1429408. Epub 2018 Jan 24. Expert Opin Ther Pat. 2018. PMID: 29338548 Review.

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Modulation of NMDA receptor function as a treatment for schizophrenia.

Cioffi CL. Cioffi CL. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5034-44. doi: 10.1016/j.bmcl.2013.07.019. Epub 2013 Jul 19. Bioorg Med Chem Lett. 2013. PMID: 23916256 Review.

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Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.

Cioffi CL. Cioffi CL. J Med Chem. 2018 Apr 12;61(7):2652-2679. doi: 10.1021/acs.jmedchem.7b00956. Epub 2017 Sep 22. J Med Chem. 2018. PMID: 28876062 Review.

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Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.

Mostyn SN, Sarker S, Muthuraman P, Raja A, Shimmon S, Rawling T, Cioffi CL, Vandenberg RJ. Mostyn SN, et al. Among authors: cioffi cl. ACS Chem Neurosci. 2020 May 6;11(9):1250-1258. doi: 10.1021/acschemneuro.9b00655. Epub 2020 Apr 9. ACS Chem Neurosci. 2020. PMID: 32191428 Free PMC article.

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Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.

Cioffi CL, Guzzo PR. Cioffi CL, et al. Curr Top Med Chem. 2016;16(29):3404-3437. doi: 10.2174/1568026616666160405113340. Curr Top Med Chem. 2016. PMID: 27048272 Review.

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Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.

Cioffi CL. Cioffi CL. Biomolecules. 2021 Jun 10;11(6):864. doi: 10.3390/biom11060864. Biomolecules. 2021. PMID: 34200954 Free PMC article. Review.

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Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.

Cioffi CL, Raja A, Muthuraman P, Jayaraman A, Jayakumar S, Varadi A, Racz B, Petrukhin K. Cioffi CL, et al. J Med Chem. 2021 Jul 8;64(13):9010-9041. doi: 10.1021/acs.jmedchem.1c00099. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138572

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Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.

Ma Z, King K, Alqahtani M, Worden M, Muthuraman P, Cioffi CL, Bakshi CS, Malik M. Ma Z, et al. Among authors: cioffi cl. PLoS One. 2019 Oct 24;14(10):e0224094. doi: 10.1371/journal.pone.0224094. eCollection 2019. PLoS One. 2019. PMID: 31648246 Free PMC article.

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Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.

Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Karunakaran K, Matta L, Choo SH, Panduga S, Buckle RN, Davis RN, Sakwa SA, Gupta P, Sargent BJ, Moore NA, Luche MM, Carr GJ, Khmelnitsky YL, Ismail J, Chung M, Bai M, Leong WY, Sachdev N, Swaminathan S, Mhyre AJ. Cioffi CL, et al. J Med Chem. 2016 Sep 22;59(18):8473-94. doi: 10.1021/acs.jmedchem.6b00914. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27559615 Free article.

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A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.

Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. Shin Y, et al. Among authors: cioffi cl. Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2420-2429. doi: 10.1016/j.bbadis.2018.04.014. Epub 2018 Apr 21. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29684583 Free PMC article.

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