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CISD2 maintains cellular homeostasis.
Shen ZQ, Huang YL, Teng YC, Wang TW, Kao CH, Yeh CH, Tsai TF. Shen ZQ, et al. Biochim Biophys Acta Mol Cell Res. 2021 Apr;1868(4):118954. doi: 10.1016/j.bbamcr.2021.118954. Epub 2021 Jan 7. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33422617 Free article. Review.
Firstly, that CISD2 has been recognized as a prolongevity gene and the level of CISD2 is a key determinant of lifespan and healthspan. In mice, Cisd2 deficiency shortens lifespan and accelerates aging. Conversely, a persistently high level of Cisd2 pro …
Firstly, that CISD2 has been recognized as a prolongevity gene and the level of CISD2 is a key determinant of lifespan and hea …
Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway.
Li Y, Xu B, Ren X, Wang L, Xu Y, Zhao Y, Yang C, Yuan C, Li H, Tong X, Wang Y, Du J. Li Y, et al. Cell Mol Biol Lett. 2022 Sep 30;27(1):81. doi: 10.1186/s11658-022-00383-z. Cell Mol Biol Lett. 2022. PMID: 36180832 Free PMC article.
BACKGROUND: CDGSH iron sulfur domain 2 (CISD2) is an iron-sulfur protein with a [2Fe-2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 is associated with the progression of multiple …
BACKGROUND: CDGSH iron sulfur domain 2 (CISD2) is an iron-sulfur protein with a [2Fe-2S] cluster, which is critical for cell prolifer …
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice.
Yeh CH, Shen ZQ, Wang TW, Kao CH, Teng YC, Yeh TK, Lu CK, Tsai TF. Yeh CH, et al. J Biomed Sci. 2022 Jul 24;29(1):53. doi: 10.1186/s12929-022-00838-7. J Biomed Sci. 2022. PMID: 35871686 Free PMC article.
BACKGROUND: The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspan. ...Tissue-spec …
BACKGROUND: The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease …
CISD2 regulates oxidative stress and mitophagy to maintain the balance of the follicular microenvironment in PCOS.
Wu HH, Zhu Q, Liang N, Xiang Y, Xu TY, Huang ZC, Cai JY, Weng LL, Ge HS. Wu HH, et al. Redox Rep. 2024 Dec;29(1):2377870. doi: 10.1080/13510002.2024.2377870. Epub 2024 Jul 15. Redox Rep. 2024. PMID: 39010730 Free PMC article.
Moreover, we want to elucidate the intricate mechanistic contribution of CISD2 to the onset and progression of PCOS. METHODS: Oxidase NOX2, mitophagy-related proteins, and CISD2 were detected by WB. ...Testosterone stimulation leads to the increase of oxidase, mitop …
Moreover, we want to elucidate the intricate mechanistic contribution of CISD2 to the onset and progression of PCOS. METHODS: Oxidase …
Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice.
Shen ZQ, Chang CY, Yeh CH, Lu CK, Hung HC, Wang TW, Wu KS, Tung CY, Tsai TF. Shen ZQ, et al. J Biomed Sci. 2024 Jan 23;31(1):15. doi: 10.1186/s12929-024-01005-w. J Biomed Sci. 2024. PMID: 38263133 Free PMC article.
BACKGROUND: CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. ...Finally, in mouse skin, hesperetin enhances CISD2 expression to ameliorate UVB-induced photoaging …
BACKGROUND: CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 …
CISD2 counteracts the inhibition of ER-mitochondrial calcium transfer by anti-apoptotic BCL-2.
Loncke J, de Ridder I, Kale J, Wagner L, Kaasik A, Parys JB, Kerkhofs M, Andrews DW, Yule D, Vervliet T, Bultynck G. Loncke J, et al. Biochim Biophys Acta Mol Cell Res. 2025 Jan;1872(1):119857. doi: 10.1016/j.bbamcr.2024.119857. Epub 2024 Oct 4. Biochim Biophys Acta Mol Cell Res. 2025. PMID: 39370046 Review.
CISD2, a 2Fe2S cluster domain-containing protein, is implicated in Wolfram syndrome type 2, longevity and cancer. ...In a cellular context, loss of CISD2 did not impede the suppression of apoptosis by BCL-2. Also, in Ca(2+)-signaling assays, absence of CISD2 …
CISD2, a 2Fe2S cluster domain-containing protein, is implicated in Wolfram syndrome type 2, longevity and cancer. ...In a cellular co …
CISD2 plays a role in age-related diseases and cancer.
Liao HY, Liao B, Zhang HH. Liao HY, et al. Biomed Pharmacother. 2021 Jun;138:111472. doi: 10.1016/j.biopha.2021.111472. Epub 2021 Mar 19. Biomed Pharmacother. 2021. PMID: 33752060 Free article. Review.
CDGSH iron-sulfur domain 2 (Cisd2) is an evolutionarily conserved protein that plays an important regulatory role in aging-related diseases and cancers. ...Cisd2 is also an oncoprotein that regulates the occurrence and development of cancer. ...
CDGSH iron-sulfur domain 2 (Cisd2) is an evolutionarily conserved protein that plays an important regulatory role in aging-related di …
Rejuvenation: Turning Back Time by Enhancing CISD2.
Yeh CH, Shen ZQ, Lin CC, Lu CK, Tsai TF. Yeh CH, et al. Int J Mol Sci. 2022 Nov 13;23(22):14014. doi: 10.3390/ijms232214014. Int J Mol Sci. 2022. PMID: 36430496 Free PMC article. Review.
This review mainly focuses on the following topics: (1) CISD2 is one of the few pro-longevity genes identified in mammals. Genetic evidence from loss-of-function (knockout mice) and gain-of-function (transgenic mice) studies have demonstrated that CISD2 is essential …
This review mainly focuses on the following topics: (1) CISD2 is one of the few pro-longevity genes identified in mammals. Genetic ev …
Cisd2 mediates lifespan: is there an interconnection among Ca2+ homeostasis, autophagy, and lifespan?
Wang CH, Kao CH, Chen YF, Wei YH, Tsai TF. Wang CH, et al. Free Radic Res. 2014 Sep;48(9):1109-14. doi: 10.3109/10715762.2014.936431. Epub 2014 Jul 29. Free Radic Res. 2014. PMID: 24974737 Review.
We created Cisd2 knockout (loss-of-function) and transgenic (gain-of-function) mice to study the role of Cisd2 in development and pathophysiology, and demonstrated that Cisd2 expression affects lifespan in mammals. In the Cisd2 knockout mice, Cisd2 …
We created Cisd2 knockout (loss-of-function) and transgenic (gain-of-function) mice to study the role of Cisd2 in development …
Enhancing CISD2 expression to retard liver aging.
Huang YL, Shen ZQ, Tsai TF. Huang YL, et al. Aging (Albany NY). 2022 Feb 28;14(4):1594-1596. doi: 10.18632/aging.203929. Epub 2022 Feb 28. Aging (Albany NY). 2022. PMID: 35247253 Free PMC article. No abstract available.
183 results