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Year Number of Results
2015 3
2016 3
2017 2
2018 1
2020 2
2021 4
2022 5
2023 7
2024 2
2025 5
2026 3

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30 results

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Page 1
Skin senescence: mechanisms and impact on whole-body aging.
Franco AC, Aveleira C, Cavadas C. Franco AC, et al. Among authors: cavadas c. Trends Mol Med. 2022 Feb;28(2):97-109. doi: 10.1016/j.molmed.2021.12.003. Epub 2022 Jan 7. Trends Mol Med. 2022. PMID: 35012887 Review.
Similar to any other tissue, the skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging, triggered by environmental factors that contribute to accelerating the skin aging process. ...In this opinion, we discuss the possible …
Similar to any other tissue, the skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging, tr …
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies.
Lucas V, Cavadas C, Aveleira CA. Lucas V, et al. Among authors: cavadas c. Pharmacol Rev. 2023 Jul;75(4):675-713. doi: 10.1124/pharmrev.122.000622. Epub 2023 Feb 2. Pharmacol Rev. 2023. PMID: 36732079 Review.
An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. ...Also, strategies to pre …
An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Among authors: cavadas c. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Neuropeptide Y: An Anti-Aging Player?
Botelho M, Cavadas C. Botelho M, et al. Among authors: cavadas c. Trends Neurosci. 2015 Nov;38(11):701-711. doi: 10.1016/j.tins.2015.08.012. Trends Neurosci. 2015. PMID: 26549884 Review.
Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination. In this review, we critically discuss age-related changes in NPY levels in the brain, together with recent findings concerning the contribution of NPY to, and impact on …
Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination. In this review, we criticall …
Obstructive Sleep Apnea and Hallmarks of Aging.
Gaspar LS, Álvaro AR, Moita J, Cavadas C. Gaspar LS, et al. Among authors: cavadas c. Trends Mol Med. 2017 Aug;23(8):675-692. doi: 10.1016/j.molmed.2017.06.006. Epub 2017 Jul 21. Trends Mol Med. 2017. PMID: 28739207 Review.
Here, we propose that OSA might anticipate/aggravate aging by inducing cellular and molecular impairments that characterize the aging process, such as stem cell exhaustion, telomere attrition and epigenetic changes. We suggest that further knowledge on the impact of …
Here, we propose that OSA might anticipate/aggravate aging by inducing cellular and molecular impairments that characterize the ag …
Primary cilia shape hallmarks of health and aging.
Silva DF, Cavadas C. Silva DF, et al. Among authors: cavadas c. Trends Mol Med. 2023 Jul;29(7):567-579. doi: 10.1016/j.molmed.2023.04.001. Epub 2023 May 1. Trends Mol Med. 2023. PMID: 37137787 Review.
Increasing evidence shows that primary cilia regulate tissue and cellular aging related features, which led us to review the evidence on their role in potentiating and/or accelerating the aging process. ...Here, we discuss the findings on primary cilia dysfunction a …
Increasing evidence shows that primary cilia regulate tissue and cellular aging related features, which led us to review the evidence …
The impact of insomnia on frailty and the hallmarks of aging.
Carvalhas-Almeida C, Cavadas C, Álvaro AR. Carvalhas-Almeida C, et al. Among authors: cavadas c. Aging Clin Exp Res. 2023 Feb;35(2):253-269. doi: 10.1007/s40520-022-02310-w. Epub 2022 Dec 30. Aging Clin Exp Res. 2023. PMID: 36583849 Free PMC article. Review.
Moreover, age-related frailty and sleep dysfunction may have a common mechanism related to the hallmarks of cellular aging. Cellular aging was categorized into nine hallmarks, such as DNA damage, telomere attrition and epigenetic changes. In the context of geriatric …
Moreover, age-related frailty and sleep dysfunction may have a common mechanism related to the hallmarks of cellular aging. Cellular …
Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline.
Franco AC, Martini H, Victorelli S, Lagnado AB, Wyles SP, Rowsey JL, Pirius N, Woo SH, Costa DG, Chaib S, Tullius SG, Tchkonia T, Kirkland JL, Khosla S, Jurk D, Cavadas C, Passos JF. Franco AC, et al. Among authors: cavadas c. Aging Cell. 2025 Jan;24(1):e14340. doi: 10.1111/acel.14340. Epub 2024 Oct 7. Aging Cell. 2025. PMID: 39374134 Free PMC article.
Cellular senescence is an established cause of cell and tissue aging. Senescent cells have been shown to increase in multiple organs during aging, including the skin. Here we hypothesized that senescent cells residing in the skin can spread senescence to distant org …
Cellular senescence is an established cause of cell and tissue aging. Senescent cells have been shown to increase in multiple organs …
Understanding neuron-glia crosstalk and biological clocks in insomnia.
Carvalhas-Almeida C, Serra J, Moita J, Cavadas C, Álvaro AR. Carvalhas-Almeida C, et al. Among authors: cavadas c. Neurosci Biobehav Rev. 2023 Apr;147:105100. doi: 10.1016/j.neubiorev.2023.105100. Epub 2023 Feb 17. Neurosci Biobehav Rev. 2023. PMID: 36804265 Free article. Review.
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.
Costa DG, Gee LM, Lee G, Sales Gomez L, Franco AC, Vizioli MG, Valdivieso K, Zhang LJ, Pirius N, Martini H, Porritt RA, Saul D, Cavadas C, Ebert S, LeBrasseur NK, Khosla S, Passos JF, Adams CM, Robbins PD, Jurk D. Costa DG, et al. Among authors: cavadas c. EMBO Mol Med. 2026 May;18(5):1530-1550. doi: 10.1038/s44321-026-00400-0. Epub 2026 Apr 1. EMBO Mol Med. 2026. PMID: 41922652 Free PMC article.
Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of tomatine found in tomato …
Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, se …
30 results